研究领域

主要从事膜性细胞结构和细胞器生物膜动态变化的研究。主要研究外泌体、新细胞器迁移体等细胞外囊泡的特征性蛋白质标记物、疾病样品中迁移体的鉴定以及探索迁移体的生理功能、在疾病中的重要作用和迁移体在疾病发生、诊断中的意义

近期论文

Mi N*, Chen Y*, Wang S, Chen M, Zhao M, Yang G, Ma M, Su Q, Luo S, Shi J, Xu J, Guo Q, Gao N, Sun Y, Chen Z, Yu L. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nature Cell Biology. 2015 Jan; 25(1): 24-38 (co-first author)
Du W*, Su QP*, Chen Y*, Zhu Y, Jiang D, Rong Y, Zhang S, Zhang Y, Ren H, Zhang C, Wang X, Gao N, Wang Y, Sun L, Sun Y, Yu L. Kinesin 1 Drives Autolysosome Tubulation. Developmental Cell. 2016 May 23; 37(4):326-36 (co-first author)
Neunuebel MR*, Chen Y*, Gaspar AH, Backlund PS Jr, Yergey A, Machner MP. De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science. 2011 Jul 22; 333(6041): 453-6 (co-first author)
Chen Y*, Tascón I*, Neunuebel MR, Pallara C, Brady J, Kinch LN, Fernández-Recio J, Rojas AL, Machner MP, Hierro A. Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD. PLOS Pathogen. 2013 May 16; (co-first author)
Chen Y*, Machner MP. Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA. Infection and Immunity. 2013 Jun 881(6): 2226-35
Chen Y*, Su Q*, Sun YJ, Yu L. Visualizing autophagic lysosome reformation in cells using in vitro reconstitution systems. Current Protocols in Cell Biology, 2018 Mar;78(1):11.24.1-11.24.15.
Chen Y, Li Y, Ma L, Yu L. Detection of migrasomes. Cell Migration: Methods and Protocols, Methods in Molecular Biology, vol. 1749, 2018
Chen Y, Li Y. Development of research into autophagic lysosome reformation. Molecules and Cells. 2018 Jan 31;41(1):45-49.
Yu L, Chen Y, Tooze SA. Autophagy pathway: cellular and molecular mechanisms. Autophagy.2017 Sep 21:1-9.
Chen Y*, Yu L,Recent progress in autophagic lysosome reformation. Traffic. 2017 Jun; 18(6): 358-361.
Chen Y*, Yu L, Research progress of membranous organelles and their subcellular structures in China. Chinese Science Bulletin 2017 May 12;
Chen Y*, Yu L, Scissors for autolysosome tubules. EMBO J. 2015 Sep 2; 34(17): 2217-8.
Chen Y*, Yu L. Autophagic lysosome reformation. Exp Cell Res. 2013 Jan 15;319(2):142-6
Machner MP*, Chen Y, Catch and release: Rab1 exploitation by Legionella pneumophila.Cell Logist. 2011 Jul 1; 1(4):133-138.