近期论文

Blusztajn, J. K., and Berse, B. (2000) The cholinergic neuronal phenotype in Alzheimer’s disease. Metab Brain Dis 15, 45-64 PubMed
◾Farber, S. A., Slack, B. E., and Blusztajn, J. K. (2000) Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer’s disease. FASEB J 14, 2198-2206 PubMed
◾Lopez-Coviella, I., Berse, B., Krauss, R., Thies, R. S., and Blusztajn, J. K. (2000) Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9. Science 289, 313-316 PubMed
◾Yang, Y., Liu, Z., Cermak, J. M., Tandon, P., Sarkisian, M. R., Stafstrom, C. E., Neill, J. C., Blusztajn, J. K., and Holmes, G. L. (2000) Protective effects of prenatal choline supplementation on seizure-induced memory impairment. J Neurosci 20, RC109 PubMed
◾Guo-Ross, S. X., Clark, S., Montoya, D. A., Jones, K. H., Obernier, J., Shetty, A. K.,
White, A. M., Blusztajn, J. K., Wilson, W. A., and Swartzwelder, H. S. (2002)
Prenatal choline supplementation protects against postnatal neurotoxicity. J Neurosci 22, RC195 PubMed
◾Holmes, G. L., Yang, Y., Liu, Z., Cermak, J. M., Sarkisian, M. R., Stafstrom, C. E., Neill, J. C., and Blusztajn, J. K. (2002) Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. Epilepsy Res 48, 3-13 PubMed
◾Mellott, T., Lopez-Coviella, I., Blusztajn, J. K., and Berse, B. (2002) Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression. Eur J Biochem 269, 850-858 PubMed
◾Brandon, E. P., Mellott, T., Pizzo, D. P., Coufal, N., D’Amour, K. A., Gobeske, K., Lortie, M., Lopez-Coviella, I., Berse, B., Thal, L. J., Gage, F. H., and Blusztajn, J. K. (2004) Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J Neurosci 24, 5459-5466 PubMed
◾Mellott, T. J., Williams, C. L., Meck, W. H., and Blusztajn, J. K. (2004) Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. Faseb J 18, 545-547 PubMed
◾Lopez-Coviella, I., Follettie, M. T., Mellott, T. J., Kovacheva, V. P., Slack, B. E., Diesl, V., Berse, B., Thies, R. S., and Blusztajn, J. K. (2005) Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A 102, 6984-6989 PubMed
◾Slack, B. E., Siniaia, M. S., and Blusztajn, J. K. (2006) Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase. J Cell Biochem 98, 672-684 PubMed
◾Glenn, M. J., Gibson, E. M., Kirby, E. D., Mellott, T. J., Blusztajn, J. K., and Williams, C. L. (2007) Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. Eur J Neurosci 25, 2473-2482 PubMed
◾Kovacheva, V. P., Mellott, T. J., Davison, J. M., Wagner, N., Lopez-Coviella, I., Schnitzler, A. C., and Blusztajn, J. K. (2007) Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem 282, 31777-31788 PubMed
◾Mellott, T. J., Follettie, M. T., Diesl, V., Hill, A. A., Lopez-Coviella, I., and Blusztajn, J. K. (2007) Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. FASEB J 21, 1311-1323 PubMed
◾Meck, W. H., Williams, C. L., Cermak, J. M., and Blusztajn, J. K. (2007) Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia. Front Integr Neurosci 1, 7 PubMed
◾Schnitzler,A. C., Lopez-Coviella, I., and Blusztajn, J. K. (2008) Purification and culture of nerve growth factor receptor (p75)-expressing basal forebrain cholinergic neurons. Nat Protoc 3, 34-40 PubMed
◾Slack, B. E., and Blusztajn, J. K. (2008) Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. J Cell Biochem 104, 1818-1831 PubMed
◾Wong-Goodrich, S. J., Mellott, T. J., Glenn, M. J., Blusztajn, J. K., and Williams, C. L. (2008) Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus. Neurobiol Dis 30, 255-269 PubMed
◾Glenn, M.J., Gibson, E.M., Kirby, E.D., Wong-Goodrich, S.J.E., Mellott, T.J., Blusztajn, J.K. and Williams, C.L. (2008) Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain Res 1237, 110-123 PubMed
◾Schnitzler, A.C., Lopez-Coviella, I. and Blusztajn, J.K. (2008) Differential modulation of nerve growth factor receptor (p75) and cholinergic gene expression in purified p75-expressing and non-expressing basal forebrain neurons by BMP9. Brain Res 1246, 19-28 PubMed
◾Kovacheva, V.P., Davison, J.M., Mellott, T.J., Rogers, A.E., Yang, S., O’Brien M.J. and Blusztajn, J.K. (2009) Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J 23, 1054-1063 PubMed
◾Davison, J.M., Mellott, T.J., Kovacheva, V.P. and Blusztajn, J.K. (2009) Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a) and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem 284, 1982-1989 PubMed
◾Johnson, A.R., Craciunescu, C.N., Guo, Z., Thresher, R.J., Blusztajn, J.K., and Zeisel, SH (2010) Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB J 24, 2752-2761 PubMed
◾Schnitzler, A.C., Lopez-Coviella, I., Mellott, T.J., Tallini, Y.N., Kotlikoff, M.I., Follettie, M.T. and Blusztajn, J.K. (2010) BMP9 induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. J Neurosci 30, 8221-8228 PubMed
◾Wong-Goodrich, S.J.E, Mellott, T.J., Liu, B., Blusztajn, J.K. and Williams, C.L. (2011) Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood. Hippocampus 21, 584-608 PubMed
◾Carey, R.M., Blusztajn, J.K. and Slack, B.E. (2011) Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC Cell Biol 12, 20 PubMed


· Blusztajn, J. K., and Berse, B. (2000) The cholinergic neuronal phenotype in Alzheimer’s disease. Metab Brain Dis 15, 45-64 PubMed
· Farber, S. A.,