个人简历

B.S., chemistry, Tsinghua University, Beijing, China, 2004
Ph.D., chemistry, Michigan State University, East Lansing, Michigan, 2009

近期论文

W. Qiang*, R.D. Akinlolu, M. Nam, �Solid-state NMR studies of the membrane disruption induced by the b amyloid peptides: perspective and difficulties�, eMagRes (invited review), 2015, in press.
W. Qiang*, W. M. Yau, and J. Schulte, �Fibrillation of b amyloid peptides in the presence of phospholipid bilayers and the consequent membrane disruption�, BBA-Biomembranes, 2015, 1848(1), 266-276.
N.G. Sgourakis, W. M. Yau, and W. Qiang*, �Modeling an in-register, parallel Iowa Ab fibril structure using solid-state NMR data from labeled samples with Rosetta�, Structure, 2015, 23(1), 216-227.
W. Qiang*, R.D. Akinlolu, M. Nam, and N. Shu, �Structural evolution and membrane interaction of the 40-residue b amyloid peptides: differences in the initial proximity between peptides and the membrane bilayer studied by solid-state nuclear magnetic resonance spectroscopy�, Biochemistry, 2014, 53(48), 7503-7514.
W. Qiang, and R. Tycko, �Solid-state NMR studies of b-amyloid fibrils and related assemblies�, in Advances in Biological Solid-state NMR: Proteins and Membrane-Active Peptides, in press, A. Naito and F. Separovic, eds., Royal Society of Chemistry.
J.X. Lu, W. Qiang, W.M. Yau, C.D. Schwieters, S.C. Meredith, and R. Tycko, �Molecular structure of b-amyloid fibrils in Alzheimer�s disease brain tissue�, Cell, 2013, 154(6), 1257-1268.
C.M. Gabrys, W. Qiang, Y. Sun, L. Xie, S.D. Schmick, and D.P. Weliky, �Solid-state nuclear magnetic resonance measurements of HIV fusion peptide 13CO to lipid 31P proximities support similar partially inserted membrane locations of the a helical and b sheet peptide structures�, J. Phys. Chem. A., 2013, 117(39), 9848-9859.
W. Qiang, K. Kelley, and R. Tycko, �Polymorph-specific kinetics and thermodynamics of β-amyloid fibril growth�, J. Am. Chem. Soc., 2013, 135(18), 6860-6871.
W. Qiang, and R. Tycko, �Zero-quantum Stochastic Dipolar Recoupling in Solid State Nuclear Magnetic Resonance�, J. Chem. Phys., 2012, 137, 104201.
K.N. Hu, W. Qiang, G. Bermejo, C.D.Schwieters, and R. Tycko, �Restraints on backbone conformations in solid state NMR studies of uniformly labeled proteins from quantitative amide 15N-15N and carbonyl 13C-13C dipolar recoupling data�, J. Magn. Reson., 2012, 218, 115-127.
W. Qiang, W.M. Yau, Y. Luo, M.P. Mattson, and R. Tycko, �Antiparallel b-sheet architecture in Iowa-mutant b-amyloid fibrils�, Proc. Natl. Acad. Sci., 2012, 109, 4443-4448.
W. Qiang*, �Signal enhancement for the sensitivity-limited solid state NMR experiments using a continuous, non-uniform acquisition scheme�, J. Magn. Reson., 2011, 213, 171-175.
K.N. Hu, W. Qiang, and R. Tycko, �A general Monte Carlo/simulated annealing algorithm for resonance assignment in NMR of uniformly labeled biopolymers�, J. Biomol. NMR, 2011, 50, 267-276.
W. Qiang, W.M. Yau, and R. Tycko, �Structural evolution of Iowa-mutant b-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth�, J. Am. Chem. Soc., 2011, 133, 4018-4029.
S. Tristram-Nagle, R. Chan, E. Kooijman, P. Uppamoochikkal, W. Qiang, D.P. Weliky, and J.F. Nagle, �HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics�, J. Mol. Biol., 2010, 402, 139-153.
C.M. Gabrys, R. Yang, C.M. Wasniewski, J. Yang, C.G. Canlas, W. Qiang, Y. Sun, and D.P. Weliky, �Nuclear magnetic resonance evidence for retention of lamellar membrane phase with curvature in the presence of large quantities of the HIV fusion peptide�, Biochim. Biophys. Acta, 2010, 1798, 194-201.
W. Qiang, Y. Sun, and D.P. Weliky, �A strong correlation between fusogenicity and membrane insertion depth of the HIV fusion peptide�, Proc. Natl. Acad. Sci., 2009, 106, 15314-15319.
W. Qiang and D.P. Weliky, �HIV fusion peptide and its cross-linked oligomers: efficient syntheses, significance of the trimer in fusion activity, correlation of b strand conformation with membrane cholesterol, and proximity to lipid headgroups�, Biochemistry, 2009, 48, 289-301.
W. Qiang, M.L.Bodner, and D.P. Weliky, �Solid-state NMR spectroscopy of HIV fusion peptides associated with host-cell-like membranes: 2D correlation spectra and distance measurements support a fully extended conformation and models for specific antiparallel strand registries�, J. Am. Chem. Soc., 2008, 130, 5459-5471.
Z. Zheng, W. Qiang, and D.P. Weliky, �Investigation of finite-pulse radiofrequency-driven recoupling methods for measurement of intercarbonyl distances in polycrystalline and membrane-associated HIV fusion peptide samples�, Magn. Reson. Chem., 2007, 45, S247-S260.