个人简历

Education
Ph.D University of Illinois 1990
B.S. University of Illinois 1985
B.A. Ohio Wesleyan University 1984
NIH Postdoctoral Fellow, University of South Carolina 1990-1993
Professional Experience
Professor of Chemistry Baylor University 1993-

近期论文

Mechanistic considerations in the synthesis of 2-aryl-indole analogues under Bischler–Mohlau conditions. MacDonough, M. T.; Shi, Z.; Pinney, K. G. Tetrahedron Letters, in press, 2015.
Synthesis of Structurally Diverse Benzosuberene Analogues and their Biological Evaluation as Anti-cancer Agents. Tanpure, R. P.; George, C. S.; Strecker, T. E.; Devkota, L.; Tidmore, J. K.; Lin, C.-M.; Herdman, C. A.; MacDonough, M. T.; Sriram, M.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic and Medicinal Chemistry, 21, 8019-8032, 2013.
Synthesis of 2-Aryl-3-Aroyl-Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent. Hadimani, M. B.; MacDonough, M. T.; Ghatak, A.; Strecker, T. E.; Lopez, R.; Sriram, M.; Nguyen, B. L.; Hall, J. J.; Kessler, R. J.; Shirali, A. R.; Liu, L.; Garner, C. M.; Pettit, G. R.; Hamel, E.; Chaplin, D. J.; Mason, R. P.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products, 76, 1668-1678, 2013.
Synthesis and Biological Evaluation of Indole-based, Anti-cancer Agents Inspired by the Vascular Disrupting Agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006). MacDonough, M. T.; Strecker, T. E.; Hamel, E.; Hall, J. J.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.Bioorganic and Medicinal Chemistry, 21, 6831-6843, 2013.
Small-Molecule Inhibitors of Cathepsin L Incorporating Functionalized Ring-Fused Molecular Frameworks. Song, J.; Jones, L. M.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Jantz, A.; Johansen, A.; Bayeh, L.; Soeung, V.; Snyder, L. K.; Lade, Jr., S. D.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorganic Medicinal Chemistry Letters, 23: 2801-2807, 2013.
Initial Evaluation of the Antitumour Activity of KGP94, a Functionalized Benzophenone Thiosemicarbazone Inhibitor of Cathepsin L. Chavarria, G. E.; Horsman, M. R.; Arispe, W. M.; Kumar, G. D. K.; Chen, S.-E.; Strecker, T. E.; Parker, E. N.; Chaplin, D. J.; Pinney, K. G.; Trawick, M. L. European Journal of Medicinal Chemistry, 58: 568-572,2012.
Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L. Song, J.; Jones, L. M.; Kumar, G. D. K.; Conner, E. S.; Bayeh, L.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Chen, S.-E.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. ACS Medicinal Chemistry Letters, 3: 450-453,2012.
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity. *Tanpure, R. P.; *George, C. S.; *Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Hamel, E.; Charlton-Sevcik, A. K.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. MedChemComm, 3: 720-724, 2012.
[* denotes authors with equal contributions]
Regioselective Synthesis of Water Soluble Monophosphate Derivatives of Combretastatin A-1. Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W. III; Pettit, G. R.; Trawick, M. L.; Pinney, K. G. Journal of Natural Products 74: 1568-1574,2011.
A Perspective on Vascular Disrupting Agents that Interact with Tubulin: Preclinical Tumor Imaging and Biological Assessment. Mason, R. P.; Zhao, D.; Liu, L.; Trawick, M. L.; Pinney, K. G. Integr. Biol. 3: 375-387, 2011.
(Invited contribution to honor Professor Mina J. Bissell for her lifetime contributions to the tumor microenvironment and research involving the extracellular matrix)
Functionalized Benzophenone, Thiophene, Pyridine, and Fluorene Thiosemicarbazone Derivatives as Inhibitors of Cathepsin L . Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Yoo, G. K.; Song, J.; Strecker, T. E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 6610-6615, 2010.
Regio- and Stereospecific Synthesis of Mono ß-D-Glucuronic Acid Derivatives of Combretastatin A-1. Tanpure, R. P.; Strecker, T. E.; Chaplin, D. J.; Siim, B. G.; Trawick, M. L.; Pinney, K. G. J. Nat. Prod. 73: 1093-1101, 2010.
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Kumar, G. D. K.; Chavarria, G. E.; Charlton-Sevcik, A. K.; Arispe, W. M.; MacDonough, M. T.; Strecker, T. E.; Chen, S.-E.; Siim, B. G.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 20: 1415-1419, 2010.
Application of the McMurry Coupling Reaction in the Synthesis of Tri- and Tetra-arylethylene Analogues as Potential Cancer Chemotherapeutic Agents. Tanpure, R. P.; Harkrider, A. R.; Strecker, T. E.; Hamel, E.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 17: 6993-7001, 2009.
Carbon-14 Radiosynthesis of Combretastatin A-1 (CA1) and its Corresponding Phosphate Prodrug (CA1P). Brown, R. T.; Murrell, V. L.; McMordie, A.; Sriram, M.; Pinney, K. G.; Sharma, S.; Chaplin, D. J. J. Labelled Compd. Rad., 52: 567-570, 2009.
Development of Synthetic Methodology Suitable for the Radiosynthesis of Combretastatin A-1 (CA1) and its Corresponding Prodrug CA1P. Shirali, A.; Sriram, M.; Hall, J. J.; Nguyen, B. L.; Guddneppanavar, R.; Hadimani, M. B.; Ackley, J. F.; Siles, R.; Jelinek, C. J.; Arthasery, P.; Brown, R. C.; Murrell, V. L.; McMordie, A.; Sharma, S.; Chaplin, D. J.; Pinney, K. G. J. Nat. Prod. 72: 414-421, 2009.
Design, Synthesis and Biological Evaluation of Dihydronaphthalene and Benzosuberene Analogs of the Combretastatins as Inhibitors of Tubulin Polymerization in Cancer Chemotherapy. Sriram, M.; Hall, J. J.; Grohmann, N. C.; Strecker, T. E.; Wootton, T.; Franken, A.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. 16: 8161-8171, 2008.
Design, Synthesis, Biochemical, and Biological Evaluation of Nitrogen-Containing Triflouro Structural Modifications of Combretastatin A-4. Hall, J. J.; Sriram, M.; Strecker, T. E.; Tidmore, J. K.; Jelinek, C. J.; Kumar, G. D. K.; Hadimani, M. B.; Pettit, G. R.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G. Bioorg. Med. Chem. Lett. 18: 5146-5149, 2008.