个人简历

Current Post: Research Lecturer in Genome Stability Sep 2016-Present
Previous Post: PostDoctoral Research Associate, University of Sheffield
Education: PhD in Cell Signalling and DNA damage. University of Dundee 2010
BSc (Hons) in Biochemistry, Queen’s University Belfast 2002
Current Grants
NWCR DTP Studentship 2016-2020
Teaching
BSX-2019 Molecular Biology and Biochemistry
MSE-1017 Key Skills in Medical Science
MSE-3008 Dissertation
Keywords
DNA repair, Genome stability, Uncharacterised proteins, cilia, centrosome, Homologous Recombination, Replication stress

近期论文

9. Staples CJ, Barone G, Myers KN, Patil AA, Beveridge RD, Maslen S, Skehel JM, Beniston R and Collis SJ. RadIP promotes DNA repair via interactions with the MRN complex. 2016, under revision
8. Beveridge RD, Staples CJ, Patil AA, Myers KN, Maslen S, Skehel JM, Boulton SJ, Collis SJ. The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling. Cell Cycle. 2014; 13(21):3450-9.
7. St­­aples CJ, Myers KN, Beveridge RD, Patil AA, Howard AE, Barone G, Lee A, Swanton C, Howell M, Maslen S, Skehel MJ, Boulton SJ and Collis SJ. Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. J Cell Sci. 2014 Jul 1; 127(Pt 13):2910-9.
6. Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ, Collis SJ. The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci. 2012 Oct 15; 125(Pt 20):4770-9.
5. Dickinson RJ, Delavaine L, Cejudo-Marín R, Stewart G, Staples CJ, Didmon MP, Trinidad AG, Alonso A, Pulido R, Keyse SM. Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways. J Biol Chem. 2011 Nov 4; 286(44):38018-26.
4. Staples CJ, Owens DM, Maier JV, Cato AC, Keyse SM. Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation. J Biol Chem. 2010 Aug 20; 285(34):25928-40.
3. Kucharska A, Rushworth LK, Staples C, Morrice NA, Keyse SM. Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK. Cell Signal. 2009 Dec;21(12):1794-805.
2. Ekerot M, Stavridis MP, Delavaine L, Mitchell MP, Staples C, Owens DM, Keenan ID, Dickinson RJ, Storey KG, Keyse SM. Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Biochem J. 2008 Jun 1; 412(2):287-98.
1. Graham DA, Staples C, Wilson CJ, Jewhurst H, Cherry K, Gordon A, Rowley HM. Biophysical properties of salmonid alphaviruses: influence of temperature and pH on virus survival. J Fish Dis. 2007 Sep; 30(9):533-43.