个人简历
My research interests are focused around using computational techniques in mass spectrometry (MS). I develop algorithms and software to compute structures for ionised molecules and their reactivity. These tools along with standard modelling programs have been used to investigate mostly the fragmentation chemistry of protonated peptides and extract direct structural information from raw experimental data acquired in tandem MS, IR & Ion Mobility spectroscopy and gas-phase H/D exchange studies.I am currently active in projects aiming at better understanding of the gas-phase fragmentation of peptide ions, that is the sequencing chemistry used in modern proteomics.
近期论文
B. Paizs, A Divide-and-Conquer Approach to Compute Collision Cross Sections in the Projection Approximation Method. Int. J. Mass. Spectrom., 2015, 378, 360-363.O. Hernandez, B. Paizs, P. Maître, Rearrangement chemistry of an ions probed by IR spectroscopy. Int. J. Mass. Spectrom., 2015, 377, 172-178.O. Hernandez, P. Pulay, P. Maître, B. Paizs, Zundel-type H-bonding in biomolecular ions. J. Am. Soc. Mass Spectrom., 2014, 25, 1511-1514.S. Durand, M. Rossa, O. Hernandez, B. Paizs, P. Maître, IR Spectroscopy of b4 Fragment Ions of Protonated Pentapeptides in the X–H (X = C, N, O) Region, J. Phys. Chem. A 2013, 107, 2508-2516.A. Somogyi, A. G. Harrison, B. Paizs, Using Gas-Phase Guest–Host Chemistry to Probe the Structures of b Ions of Peptides, J. Am. Soc. Mass Spectrom., 2012, 23, 2055-2058.M. C. Bernier, B. Paizs, V. H. Wysocki, Influence of a Gamma Amino Acid on the Structures and Reactivity of Peptide a3 Ions. Int. J. Mass. Spectrom., 2012, 316-318, 259-267.C. L. Moss, J. Chamot-Rooke, J. Brown, I. Campuzano,K. Richardson, M. Bush, B. J. Bythell, B. Paizs, F. Turecek, Assigning Structures to Gas-Phase Peptide Cations and Cation-Radicals. An IRMPD, Ion Mobility, Electron Transfer, and Computational Study of a Histidine Peptide Ion, J. Phys. Chem. B 2012, 116, 3445-3456.B. J. Bythell, O. Hernandez, V. Steinmetz, B. Paizs, P. Maître, Tyrosine Side-chain Catalyzed Proton Transfer in the YG a2 Ion Revealed by Theory and IR Spectroscopy in the ‘Fingerprint’ and X-H (X=C, N, O) Stretching Regions, Int. J. Mass. Spectrom.,2012, 316-318, 227-234.T. N. Wassermann, O. V. Boyarkin, B. Paizs, T. R. Rizzo, Conformation-Specific Spectroscopy of Peptide Fragment Ions in a low-Temperature Ion Trap, J. Am. Soc. Mass Spectrom., 2012, 23, 1029-1045.B. Paizs, B. J. Bythell, and P. Maître, Rearrangement Pathways of the a4 Ion of Protonated YGGFL Characterized by IR Spectroscopy and Modeling, J. Am. Soc. Mass Spectrom., 2012, 23, 664-675.R. K. Sinha, U. Erlekam, B. J. Bythell, B. Paizs, and P. Maître, Diagnosing the Protonation Site of b2 Peptide Fragment Ions using IRMPD in the X–H (X = O, N,and C) Stretching Region, J. Am. Soc. Mass Spectrom., 2011, 22, 1645-1650.C. Bleiholder, S. Suhai, A. G. Harrison, and B. Paizs, Towards Understanding the Tandem Mass Spectra of Protonated Oligopeptides. 2: The Proline Effect in Collision-Induced Dissociation of Protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp), J. Am. Soc. Mass Spectrom., 2011, 22, 1032-1039.B. J. Bythell, P. Maître, and B. Paizs, Cyclization and Rearrangement Reactions of an Fragment Ions of Protonated Peptides, J. Am. Chem. Soc., 2010, 132, 14766–14779.B. J. Bythell, I. P. Csonka, S. Suhai, D. F. Barofsky, B. Paizs, Gas-phase Structure and Fragmentation Pathways of Singly Protonated Peptides with N-terminal Arginine, J. Phys. Chem. B 2010, 114, 5076–5082.B. J. Bythell, M. Knapp-Mohammady, B. Paizs, A. G. Harrison, Effect of the His Residue on the Cyclization of b Ions, J. Am. Soc. Mass Spectrom., 2010, 21, 1352-1363.F. Tureček, T. W. Chung, C. L. Moss, J. A. Wyer, A. Ehlerding, A. I. S. Holm, H. Zettergren, S. B. Nielsen, P. Hvelplund, J. Chamot-Rooke, B. J. Bythell, and B. Paizs, The Histidine Effect. Electron Transfer and Capture Cause Different Dissociations and Rearrangements of Histidine Peptide Cation-Radicals, J. Am. Chem. Soc., 2010, 132, 10728–10740.B. J. Bythell, R. P. Dain, S. S. Curtice, J. Oomens, J. D. Steill, G. S. Groenewold, B. Paizs, M. J. Van Stipdonk, Structure of [M + H - H2O](+) from Protonated Tetraglycine Revealed by Tandem Mass Spectrometry and IRMPD Spectroscopy, J. Phys. Chem. A 2010, 114, 5076-5082.C. Bleiholder and B. Paizs, Competing Gas-phase Fragmentation Pathways of Asparagine-, Glutamine-, and Lysine-containing Protonated Dipeptides, Theor. Chem. Acc. 2010, 125, 387-396. F. Tureček, S. Panja, J. A. Wyer, A. Ehlerding, H. Zettergren, S. B. Nielsen, P. Hvelplund, B. J. Bythell, and B. Paizs, Carboxyl-Catalyzed Prototropic Rearrangements in Histidine Peptide Radicals upon Electron Transfer. Effects of Peptide Sequence and Conformation, J. Am. Chem. Soc., 2009, 131, 16472–16487.B. J. Bythell, Á. Somogyi, S. Suhai, and B. Paizs, Proton-driven Amide Bond Cleavage Pathways of Gas-Phase Peptide Ions Lacking Mobile Protons, J. Am. Chem. Soc., 2009, 131, 14057–14065.U. Erlekam, B. J. Bythell, D. Scuderi, M. Van Stipdonk, B. Paizs, and P. Maître, Infrared Spectroscopy of Fragments of Protonated Peptides: Direct Evidence for Macro-cyclic Structures of b5 Ions, J. Am. Chem. Soc., 2009, 131, 11503–11508.B. J. Bythell, U. Erlekam, B. Paizs, and P. Maître, Infrared Spectroscopy of Fragments from Doubly Protonated Tryptic Peptides, ChemPhysChem, 2009, 10, 883-885.M. Knapp-Mohammady, A. B. Young, B. Paizs, and A. G. Harrison, Fragmentation of Doubly-Protonated Pro-His-Xxx Tripeptides: Formation of b22+ Ions, J. Am. Soc. Mass Spectrom., 2009, 20, 2135-2143.B. J. Bythell, Á. Somogyi, and B. Paizs, What is the Structure of b2 Ions Generated from Doubly Protonated Tryptic Peptides? J. Am. Soc. Mass Spectrom., 2009, 20, 618-624. C. Bleiholder, S. Osburn, T. D. Williams, S. Suhai, M. Van Stipdonk, A. G. Harrison, and B. Paizs, Sequence Scrambling Fragmentation Pathways of Protonated Peptides, J. Am. Chem. Soc., 2008, 130, 17774–17789.
