个人简历

2015 - date Associate Dean Enterprise and Impact, LHS, Aston University
2013-date Reader in Molecular Biology, Aston University
2013 BBSRC Commercial Innovator of the Year
2013 Aston Excellence Award for Outstanding Contribution to Innovation and/or Technological Improvement
2009-2012 Course Director, MSc Biotechnology
2006-2013 Senior Lecturer in Molecular Biology, LHS, Aston University
2005-2006 LHS Innovation Fellow, Business Partnership Unit (partial secondment)
2004-2005 CEO, ProtaMAX Ltd 2003-2004 Medici Fellow (Commercialisation and Entrepreneurial Training)
1995-2006 Lecturer in Molecular Biology, LHS, Aston University
1993-94 Research Fellow, Harvard Medical School (PI: Prof. C.C. Richardson)
1989-92 PhD, UMIST (Supervisor: Prof. T.A. Brown)
1986-89 BSc Hons Biochemistry (Class 1) UMIST (now integrated into the University of Manchester)

近期论文

Chen, X., Liu, C., Hughes, M.D., Nagel, D.A. Hine, A.V. and Zhang, L. (2015)EDC-mediated oligonucleotide immobilization on a long period grating optical biosensor.J. Biosens. Bioelectron. 6, 173. Link to article.
Frigotto L., Smith, M.E., Brankin, C., Sedani, A., Cooper, S.E., Kanwar, N., Evans, D., Svobodova, S., Baar, C., Glanville, J, Ullman, C.G. and Hine, A.V. (2015)Codon-precise, synthetic, antibody fragment libraries built using automated hexamer codon additions and validated through Next Generation Sequencing.Antibodies 4, 88-102. Link to article.
Chimonides, G. F., Behrendt, J. M., Chundoo, E., Bland, C., Hine, A. V., Devitt, A., Nagel, D. A. and Sutherland, A. J. (2014)Cellular uptake of ribonuclease A functionalised core–shell silica microspheres J Mater Chem B, 2, 7307-7315 (Front cover). Link to article.
Nagel, D., Behrendt, J.M., Chimonides, G.F., Torr, E E., Devitt, A., Sutherland, A.J. and Hine A.V. (2014) Polymeric Microspheres as Protein Transduction Reagents. Mol. Cell Proteomics, 13, 1543-1551 (Front cover). Link to article.
Behrendt, J.M., Nagel, D., Chundoo, E., Alexander, L.M., Dupin, D., Hine, A.V., Bradley, M. and Sutherland, A.J. (2013). Synthesis and characterization of dual-functionalized core-shell fluorescent microspheres for bioconjugation and cellular delivery. PLoS ONE. 8, 3, e50713. Link to article.
Ashraf, M., Frigotto, L., Smith, M.E., Patel, S., Hughes, M.D., Poole, A.J., Hebaishi, H.R.M., Ullman, C.G. and Hine, A.V. (2013) ProxiMAX randomisation: a new technology for non-degenerate saturation mutagenesis of contiguous codons. Biochem. Soc. Trans. 41, 1189-1194. Link to article.
Poole, A. J., Ullman, C. G. and Hine, A. V. (2013). The integration of ProxiMAX randomisation with CIS display for the high-throughput production of novel peptides.Protein engineering: new approaches and applications. A joint Biochemical Society / Protein Society conference. Abstract PO49. Link to abstract.
Ashraf, M., Hughes, M.D. and Hine, A.V. (2013) Oligonucleotide library encoding randomised peptides.Patent (granted) US 8357638 B2. Link to patent.
Wang, X., Hine, A.V. and Lowe, D (2012) Signal Processing Issues of High–Dimensional Visual Informatics: A Study in Protein–DNA Binding Patterns. 9th IMA International Conference on Mathematics in Signal Processing, UK.
Ashraf, M., Hughes, M.D. and Hine, A.V. (2012) Oligonucleotide library encoding randomised peptides. Patent (granted) EP 2236612. Link to patent.
Ashraf, M., Hughes, M.D. and Hine, A.V. (2011) Oligonucleotide library encoding randomised peptides. Patent (granted) EP 1907548. Link to patent.
Barbosa, H.S.C., Hine, AV., Brocchini, S., Slater, N.K.H. and Marcos, J.C. (2010). Dual affinity method for plasmid DNA purification in aqueous two-phase systems. J. Chromatography A, 1217, 1429-1436. Link to article.
Hine, AV., Chen X.F., Hughes M.D., Zhou, K.M., Davies, E., Sugden K., Bennion I., and Zhang L. (2009) Optical fibre-based detection of DNA hybridization. Biochem. Soc. Trans. 37, 445-449. Link to article.
Behrendt, J.M., Afzaal, M., Alexander, L.M., Bradley, M., Hine, A.V., Nagel, D., O'Brien, P., Presland, K. and Sutherland, A.J. (2009) Thiol-containing microspheres as polymeric ligands for the immobilisation of quantum dots. J. Mater. Chem.19, 215-221. Link to article.
Barbosa, H., Hine, A.V., Brocchini, S., Slater, N.K.H. and Marcos, J.C. (2008). Affinity partitioning of plasmid DNA with a zinc finger protein. J Chromatogr. A 1206, 105-12. Link to article.
Chen, X., Zhou, K., Hughes, M., Davies, E., Zhang, L., Hine, A., Sugden, K. and Bennion, I. (2008). DNA hybridisation biosensor based on dual-peak long-period grating. AOE 2007: Asia Optical Fiber Communication & Optoelectronic Exposition & Conference, Conference Proceedings. pp 87-89. Link to abstract.
Darby, R.A.J., Forde, G.M., Slater, N.K.H. and Hine, A.V. (2007) Affinity purification of plasmid DNA directly from crude bacterial cell lysates. Biotechnol. Bioeng. 98, 1103-1108. Link to article.
Chen X.F., Zhang L., Zhou, K.M., Davies, E., Sugden K., Bennion I., Hughes M.D. and Hine, AV. (2007) Real-time detection of DNA interactions with long-period fiber-grating-based biosensor. Optics Lett. 32, 2541-2543. Link to article.
Chen, X.F., Zhou, K., Hughes, M.D., Davies, E., Zhang, L., Hine, A.V., Sugden, K. and Bennion, I. (2007) DNA hybridisation biosensor based on dual-peak long-period grating. Optical Fiber Communication and Optoelectronics Conference, 2007 Asia. IEEE, p. 87-89. Link to abstract.
Chen, X.F., Hughes, M.D., Zhou, K., Davies, E., Zhang, L., Hine, A.V. and Bennion, I. (2007) Long-period fibre grating based biosensor for detection of DNA hybridisation. Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides, OSA Technical Digest (CD). Optical Society of America, paper BTuE4. Link to abstract.