个人简历

1993年获医学学士学位，1996年获医学硕士学位， 2002年获医学博士学位。2002-2005年在美国Baylor医学院进行博士后研究

研究领域

主要从事心肌缺血、动脉粥样硬化等疾病发病机制及其防治的研究，尤其对血管内皮损伤及功能紊乱、血管炎症反应有较深入的研究

近期论文

1. Zhao LY, Li J, Yuan F, Li M, Zhang Q, Huang YY, Pang JY, Zhang B, Sun FY, Sun HS, Li Q, Cao L, Xie Y, Lin YC, Liu J, Tan HM(co-corresponding author), Wang GL*. Xyloketal B Attenuates Atherosclerotic Plaque Formation and Endothelial Dysfunction in Apolipoprotein E Deficient Mice. Mar. Drugs 2015;13(4):2306-2326 2. Tan H*(corresponding author), Shi C, Jiang X, Lavelle M, Yu C, Yang X, Wang H*. Hyperhomocysteinemia promotes vascular remodeling in vein graph in mice. Front Biosci (Landmark Ed). 2014;19:967-985 3. Cao L, Lou X, Zou Z, Mou N, Wu W, Huang X*, Tan H*(corresponding author). Folic acid attenuates hyperhomocysteinemia-induced glomerular damage in rats. Microvasc Res. 2013;89:146-152 4. Lan TH, Huang XQ, Tan HM* (corresponding author). Vascular Fibrosis in Atherosclerosis. Cardiovasc Pathol. 2013;22(5):401-407 5. Ding B, Yuan J, Huang X, Wen W, Zhu X, Liu Y, Li H, Lu Y, He L, Tan H*(co-corresponding author), She Z*. New Dimeric Members of the Phomoxanthone Family: Phomolactonexanthones A, B and Deacetylphomoxanthone C Isolated from the Fungus Phomopsis sp. Mar Drugs 2013;11(12):4961-4972 6. Zhang Q, Li Q, Chen Y, Huang X, Yang IH, Cao L, Wu WK, Tan HM* (corresponding author). Homocysteine-impaired angiogenesis is Associated with VEGF/VEGFR inhibition. Front Biosci. 2012;E4:2525-2535 7. Lan TH, Xu ZW, Wang Z, Wu YL, Wu WK*, Tan HM*(corresponding author). Ginsenoside Rb1 prevents homocysteine-induced endothelial dysfunction via PI3K/Akt activation and PKC inhibition. Biochem Pharmacol. 2011;82(2):148-155 8. Yan TT, Li Q, Zhang XH, Wu WK, Sun J, Li L, Zhang Q, Tan HM*(corresponding author). Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/ endothelial nitric oxide synthase signalling. Clin Exp Pharmacol Physiol.. 2010;37(11):1071-1077 9. Li L, Zhang XH, Yan TT, Li Q, Liu SK, Wu LL, Yan C*, Tan HM* (corresponding author). Xiaoyaosan-containing serum inhibits corticosterone-induced apoptosis in PC12 cells by downregulating [Ca2+]i overload. Neural Regeneration Research. 2010;5(18):1396-1402 10. Tan H, Jiang X, Yang F, Li Z, Liao D, Trial J, Magera MJ, Durante W, Yang X, Wang H*. Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res, 2006;69(1):253-262 11. Liao D, Tan H, Hui R, Li Z, Jiang X, Gaubatz J, Yang F, Durante W, Chan L, Schafer AI, Pownall HJ, Yang X, Wang H*. Hyperhomocysteinemia Decreases Circulating High-Density Lipoprotein by Inhibiting Apolipoprotein A-I Protein Synthesis and Enhancing HDL Cholesterol Clearance. Circ. Res. 2006;99(6):598-606 12. Wang H*, Tan H, Yang F, Mechanisms in homocysteine-induced vascular disease. Drug Discovery Today (Disease mechanisms). 2005;2(1):25-31 13. YANG F, TAN HM, WANG H*. Hyperhomocysteinemia and atherosclerosis. Acta Physiologica Sinica, 2005;57(2):103-114 14. Jiang X, Yang F, Tan H, Liao D, Bryan RM Jr, Randhawa JK, Rumbaut RE, Durante W, Schafer AI, Yang X, Wang H*. Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol., 2005; 25(12):2515-2521