个人简历

2000-至今，主任医师、行政主任, 南京大学医学院附属鼓楼医院内分泌科
2012-至今，教授、博导，南京大学医学院

研究领域

糖尿病发病机制与临床诊疗技术

近期论文

1.Gu W, Hu J, Wang W, Li L, Tang W, Sun S, Cui W, Ye L, Zhang Y, Hong J, Zhu D*, Ning G*. Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes. Diabetes Care, 2012, 35(7):1413-9.
2.Hu Y, Li L, Xu Y, Yu T, Tong G, Huang H, Bi Y, Weng J*, Zhu D*. Short-term intensive therapy in newly diagnosed type 2 diabetes partially restores both insulin sensitivity and β-cell function in subjects with long-term remission. Diabetes Care, 2011, 34(8):1848-1853.
3. Bi Y, Wu W, Shi J, Liang H, Yin W, Chen Y, Tang S, Cao S, Cai M, Shen S, Gao Q, Weng J, Zhu D*. Role for sterol regulatory element-binding protein-1c activation in mediating skeletal muscle insulin resistance via repressing insulin receptor substrate-1 transcription. Diabetologia, 2014, 57(3):592-602.
4. Bi Y, Zeng L, Zhu D*, Yan J, Zhang Y, Tong G, Mu P, Shen S, Hu Y, Yu Q, Liang H, Weng J*. Association of β-cell function and insulin sensitivity with fasting and 2h plasma glucose in a large Chinese population. Diabetes Obes Metab, 2012, 14(2):174-80.
5. Zhang M, Tong G, Liu Y, Mu Y, Weng J, Xue Y, Luo Z, Xue Y, Shi L, Wu X, Sun S, Zhu Y, Cao Y, Zhang J, Huang H, Niu B, Li H, Guo Q, Gao Y, Li Z, Ning G, Zhu D*, Li X*; HHIS Study Group. Sequential Versus Continual Purified Urinary FSH/hCG in Men With Idiopathic Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab, 2015, 100(6):2449-55.
6. Li L, Shen S, Ouyang J, Hu Y, Hu L, Cui W, Zhang N, Zhuge Y, Chen B, Xu J, Zhu D*. Autologous Hematopoietic Stem Cell Transplantation Modulates Immunocompetent Cells and Improves Beta Cell Function in Chinese Patients with New Onset of Type 1 Diabetes. J Clin Endocrinol Metab, 2012, 97(5):1729-1726.
7. Ge Z, Zhang P, Hong T, Tang S, Meng R, Bi Y*, Zhu D*. Erythropoietin via PPAR-dependent AKT activation alleviates hepatic insulin resistance. Sci Rep, 2015, 5:17878.
8. Chen H, Sun C, Guo W, Meng R, Du H, Qi Q, Gu X, Li L, Zhang K, Zhu D*, Wang Y*. AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population. Mol Cell Endocrinol, 2011, 332(1-2):301-5.
9. Zhu Y, Yang R, McLenithan J, Yu D, Wang H, Wang Y, Singh D, Olson J, Sztalryd C, Zhu D*, Gong D*. Direct Conversion of Human Myoblasts into Brown-Like Adipocytes by Engineered Super-Active PPAR gamma. Obesity, 2015, 23(5):1014-21.
10. Jing Y, Sun Q, Bi Y, Shen S, Zhu D*. SLC30A8 polymorphism and type 2 diabetes risk: Evidence from 27 study groups. Nutr Metab Cardiovasc, 2011, 21(6):398-405.
11. Zhang Y, Shi L, Mei H, Zhang J, Zhu Y, Han X, Zhu D*. Inflamed macrophage microvesicles induce insulin resistance in human adipocytes. Nutr Metab (Lond). 2015, 6, 12:21.
12. Li C, Yang H, Tong G, Shen S, Feng W, Bi Y*, Zhu D*. Correlations between A1c, fasting glucose, 2h postload glucose, and β-cell function in the Chinese population. Acta Diabetologica, 2014, 51(4):601-608.
13. Bi Y, Zhang B, Xu W, Yang H, Feng W, Li C, Tong G, Li M, Wang X, Shen S, Zhu B, Weng J*, Zhu D*. Effects of Exenatide, Insulin, and Pioglitazone on Liver Fat Content and Body Fat Distributions in Newly Diagnosed Subjects with Type 2 Diabetes. Acta Diabetol, 2014, 51(5):865-73.
14. Bi Y, Zhu D*, Jing Y, Hu Y, Feng W, Shen S, Tong G, Shen X, Yu T, Song D, Yang D. Decreased beta cell function and insulin sensitivity contributed to increasing fasting glucose in Chinese. Acta Diabetol, 2012,49, Suppl 1:S51-8.
15. Tang W, Xu Q, Hong T, Tong G, Feng W, Shen S, Bi Y*, Zhu D*. Comparative efficacy of anti-diabetic agents on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized and non-randomized studies. Diabetes Metab Res Rev, 2016 ;32(2):200-16.
16. Bi Y, Tong G, Yang H, Cai M, Ma J, Liang J, Xin B, Miao H, Peng Z, Zhu D*. The Beneficial Effect of Metformin on beta-Cell Function and its Relationship to Insulin Sensitivity in Lean Subjects With Newly Diagnosed Type 2 Diabetes. Diabetes Metab Res Rev, 2013, 29(8):664-72.
17. Meng R, Zhu D*, Bi Y, Yang D, Wang Y*. Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice. PLOS One, 2013, 8(1):e53557.
18. Li P, Pan F, Hao Y, Feng W, Song H, Zhu D*. SGK1 is regulated by metabolic-related factors in 3T3-L1 adipocytes and overexpressed in the adipose tissue of subjects with obesity and diabetes. Diabetes Res Clin Pract. 2013, 102(1):35-42.
19. Feng B, Meng R, Huang B, Shen S, Bi Y, Zhu D*. Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice. Free Radic Res, 2016, 50(3):314-27.
20. Li P, Hao Y, Pan FH, Zhang M, Ma JQ, Zhu D*. SGK1 inhibitor reverses hyperglycemia partly through decreasing glucose absorption. J Mol Endocrinol. 2016; 56(4):301-9.