个人简历

1989 年获南开大学生物化学学士学位，1992年获南开大学分子生物学硕士学位， 1999年获美国芝加哥医学院（Finch University of Health Sciences/The Chicago Medical School）药理和分子生物学博士学位。1999年至2005年，在美国伊利诺斯大学芝加哥分校生物化学和分子遗传系完成博士后研究后，先后任该系讲师和研究助理教授。2006年受聘湖南大学985工程“细胞组织工程方向”首席科学家。2008年任科技部国际合作司“生物医学与生命分析化学国际科技合作基地（湖南大学）”主任。现任湖南大学生物学院院长。湖南省“芙蓉学者”特聘教授，教育部“新世纪优秀人才支持计划”获得者，湖南省自然科学杰出青年基金获得者，湖南省121人才工程第一层次人选。2010年获中国侨界创新人才贡献奖。兼任湖南省政协委员、湖南欧美同学会理事、湖南省知识份子联谊会理事、湖南省侨联委员。教育背景 1989 年获南开大学生物化学学士学位 1992年获南开大学分子生物学硕士学位 1999年获美国芝加哥医学院（Finch University of Health Sciences/The Chicago Medical School）药理和分子生物学博士学位 工作履历 1999–2002 Postdoctoral Fellow, Dept. of Molecular Genetics, University of Illinois at Chicago, USA, Advisor: Dr. Robert H. Costa 2002–2006 Research Assistant Professor, Dept. of Biochemistry and Molecular Genetics, University of Illinois at Chicago, USA 2006–2010 Professor, Biomedical Engineering Center, Hunan University, China 2010–2015 Professor, Director of Department of Biomedical Engineering, Vice Dean of College of Biology, Hunan University, China 2015-Present Professor, Dean of College of Biology, Hunan University, China

研究领域

1. 干细胞的多能性与定向分化：特定转录因子对干细胞多能性及分化的调控机制。2. 肿瘤分子生物学：特定转录因子调节肿瘤细胞迁移、干性、增殖、细胞稳态等的分子机制。3. 肿瘤基因治疗：基因治疗载体规模化生产工艺；基因治疗药物的药效分析

近期论文

1. Difei Dong, Lei Meng, Qiqi Yu, Guixiang Tan, Miao Ding, and Yongjun Tan*. Stable expression of FoxA1 promotes pluripotent P19 embryonal carcinoma cells to be neural stem-like cells. Gene Expression. 2012. 15: 153-162. 2. Zhongqiu Xie, Guixiang Tan, Miao Ding, Difei Dong, Tuanhui Chen, Xiangxian Meng, Xiaoqin Huang, and Yongjun Tan*. Foxm1 Transcription Factor is Required for Maintainance of Pluripotency of P19 Embryonal Carcinoma Cells. Nucleic Acids Research 38, 8027-8038. 2010 3. Hui Chen, Chao Yang, Li Yu, Li Xie, Jun Hu, Liang Zeng, and Yongjun Tan*. Adenovirus-Mediated RNA Interference Targeting FOXM1 Transcription Factor Suppresses Cell Proliferation and Tumor Growth of Nasopharyngeal Carcinoma. J Gene Med. 2012. 14: 231-240. 4. Yongjun Tan*, Yan Chen, Li Yu, Hong Zhu, Xiangxian Meng, Xiaoqin Huang, Lei Meng, Miao Ding, Zhendong Wang, and Lianhua Shan. Two fold Elevation of Expression of FoxM1 Transcription Factor in Mouse Embryonic Fibroblasts Enhances Cell Cycle Checkpoint by Stimulating p21 and Chk1 Transcription. Cell Proliferation 43, 494–504. 2010 5. Yongjun Tan*, Zhongqiu Xie, Miao Ding, Zhendong Wang, Qiqi Yu, Lei Meng, Hong Zhu, Xiaoqin Huang, Li Yu, Xiangxian Meng, and Yan Chen. Increased Levels of FoxA1 Transcription Factor in Pluripotent P19 Embryonal Carcinoma Cells Stimulate Neural Differentiation. Stem Cells and Development 19: 1365-1374. 2010 6. Yongjun Tan*, Pradip Raychaudhuri, and Robert H. Costa. Chk2 mediates stabilization of FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol. Cell. Biol. 27:1007-1016. 2007 7. Zhen Zhang, Chao Yang, Wei Gao, Tuanhui Chen, Tingting Qian, Jun Hu, and Yongjun Tan*. (2015) FOXA2 Attenuates the Epithelial to Mesenchymal Transition by Regulating the Transcription of E-cadherin and ZEB2 in Human Breast Cancer. Cancer Letters 361: 240-250. 8. Yan Chen, Lei Meng, Qiqi Yu, Difei Dong, Guixiang Tan, Xiaoqin, Huang*, and Yongjun Tan*. (2015) The miR-134 attenuates the expression of transcription factor FOXM1 during pluripotent NT2/D1 embryonal carcinoma cell differentiation. Exp Cell Res. 330: 442-450. 9. Guixiang Tan, Liang Cheng, Tuanhui Chen, Li Yu*, and Yongjun Tan*. (2014) Foxm1 Mediates LIF/Stat3-Dependent Self-Renewal in Mouse Embryonic Stem Cells and Is Essential for the Generation of Induced Pluripotent Stem Cells. PLoS One 9: e92304. 10. Tuanhui Chen, Sijia He, Zhen Zhang, Wei Gao, Li Yu*, and Yongjun Tan*. (2014) Foxa1 Contributes to the Repression of Nanog Expression by Recruiting Grg3 during the Differentiation of Pluripotent P19 Embryonal Carcinoma Cells. Exp Cell Res 326: 326-335. 11. Tuanhui Chen, Jiawan Xiong, Chao Yang, Lianhua Shan, Guixiang Tan, Li Yu*, and Yongjun Tan*. (2014) Silencing of FOXM1 transcription factor expression by adenovirus-mediated RNA interference inhibits human hepatocellular carcinoma growth. Cancer Gene Ther. 21: 133-138. 12. Su, Hongyan; Meng, Xiaochun; Guo, Qiuping; Tan, Yongjun; Cai, Qingyun; Qin, Hongtao; *Meng, Xiangxian. (2014) Label-free DNAsensor with PCR-like sensitivity based on background reduction and target-triggered polymerization amplification. Biosensors and Bioelectronics 52: 417-421. 13. Chao Yang, Hui Chen, Guixiang Tan, Wei Gao, Liang Cheng, Xia Jiang, Li Yu, and Yongjun Tan*. (2013) FOXM1 Promotes the Epithelial to Mesenchymal Transition by Stimulating the Transcription of Slug in Human Breast Cancer. Cancer Letters 340: 104-112. 14. Chao Yang, Hui Chen, Li Yu, Lianhua Shan, Li Xie, Jun Hu, Tuanhui Chen, and Yongjun Tan*. (2013) Inhibition of FOXM1 Transcription Factor Suppresses Cell Proliferation and Tumor Growth of Breast Cancer. Cancer Gene Ther. 20: 117-124. 15. Su, Hongyan; Long, Jiabao; Guo, Qiuping; Meng, Xiaochun; Tan, Yongjun; Cai, Qingyun; Chen, Zhuo; *Meng, Xiangxian. (2013) Long-tail probe-mediated cycled strand displacement amplification: Label-free, isothermal and sensitive detection of nucleic acids. Talanta 116: 330-334. 16. Xingbo Shi, Zhongqiu Xie, Yuehong Song, Yongjun Tan, Edward S. Yeung, Hongwei Gai*. Super-resolution Spectral Imaging Microscopy of Multi-color Quantum Dot Complex. Analytical Chemistry 84, 1504–1509. 2012 17. Meng, X.; Yang, X.; Wang, K.; Guo, Q.; Tan, Y.; Mo, Q.; Xu, X. Direct fluorescence detection of point mutations in human genomic DNA using microbead-based ligase chain reaction. Talanta 80: 1725-1729. 2010