肖瑞平
近期热点
资料介绍
研究领域
肖瑞平教授的研究方向主要集中在G蛋白偶联受体 (GPCR) 及其信号转导网络,尤其是心脏β肾上腺素受体(β-AR)亚型功能选择性信号转导及重大心血管疾病相关GPCR新药物靶点的基础研究。自80年代末开始,她系统地研究了心肌细胞β-AR不同亚型的信号转导机制及其生理学、病理学意义,取得了一系列重要成果,迄今已在国际一流学术刊物上发表论文100余篇,引用近5000次。她的这些研究工作得到了国际同行的广泛认同。她经常为Science STKE、Circulation、Circulation Research、Trends inPharmacological Sciences等国际一流学术刊物撰写特邀综述或评论。肖瑞平教授兼具医学和分子生物学背景,长期从事的心血管疾病药物靶点研究。2003年至今任北京大学分子医学研究所所长,于2010年全职回国。近期论文
1. Cao CM, Zhang Y, Weislede N, Ferrante C, Wang XH, Lv F, Zhang Y, Song RS, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP*, MG53 constitutes a primary determinant of cardiac ischemic preconditioning.CIRCULATION, 121: 2565-74, 2010.2. Chen KH, Guo XM, Ma DL, Guo YH, Li Q, Li P, Qiu X, Xiao RP*, Tang J, Dysregulation of A Novel HyperplasiaSuppressor Gene Triggers Vascular Proliferative Disorders. NATURE CELL BIOLOGY, 6:872-883, 2004.3. Zhu WZ, Zheng M, Lefkowitz RJ, Koch WJ, Kobilka B, Xiao RP*, Dual modulation of cardiac cell survival and cell death by 2-adrenergic signaling in adult mouse heart cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98: 1607-1612, 2001.4. Zhu WZ, Wang SQ, Chakir K, Kolbilka BK, Cheng H, Xiao RP*, Linkage of 1-adrenergic stimulation to apoptotic heartcell death through protein kinase A-independent activation of Ca2+/Calmodulin Kinase II, JOURNAL OF CLINICALINVESTIGATION,111:617-625, 2003.5. Xiao RP*, Cheng H, Lederer WJ, Suzuki T, Lakatta EG, Dual regulation of Ca2+/calmodulin-dependent Kinase IIactivity by membrane voltage and by calcium influx. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 91: 9659-9663, 1994.标签:
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