个人简历

1986年毕业于河南医科大学临床医学专业
1989年、1992年于哈尔滨医科大学分别获医学遗传学硕士学位和医学博士学位
1992-1994年在北京大学医学部公共卫生与预防医学博士后流动站做博士后研究，指导教师庄辉院士
1994-1997年在北医三院中心实验室工作。
1997-2005年先后留学瑞典Karolinska医学院、美国宾夕法尼亚大学等。

研究领域

主要从事病毒性肝炎的实验室诊断、HBV感染相关肝癌发病机制等研究。

近期论文

1.Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population. Int J Biol Markers, 2011. 26(3): 181-187.
2.Aberrant expression of microRNA 155 may accelerate cell proliferation by targeting sex-determining region Y box 6 in hepatocellular carcinoma. Cancer, 2011（Epub）
3.A higher correlation of HCV core antigen with CD4+ T cell counts compared with HCV RNA in HCV/HIV-1 coinfected patients. PLoS One, 2011. 6(8): e23550.
4.Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients. Virol J, 2011. 8: p 279.
5.Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine. Vaccine, 2011. 29(4): 706-711.
6.PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viralload in chronic hepatitis C patients. Virol J, 2010. 7: p. 310
7.SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma. Epigenetics, 2010. 5(8): 743-749.
8.Epidemiology and prevention of hepatitis B virus infection in China. Lu FM., Li T., Liu S. and Zhuang H. Journal of Viral Hepatitis, 2010, 17 (Suppl. 1): 4–9.
9.Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were associated with impaired dendritic cells function in HCV infection. J Med Virol, 2010. 82(7): 1152-1159.
10. Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection. Arch Virol, 2010. 155(5): 627-634
11.Association between epidermal growth factor 61A/G polymorphism and hepatocellular carcinoma susceptibility in Chinese patients. Liver Int, 2010. 30(1): 112-118.