研究领域

致力于设计、合成和运用小分子开展化学生物学研究，探索和调控生命体系。针对具有生物活性的复杂有机小分子，具体的工作主要集中围绕两个方向展开：一是小分子的结构和活性的关系以及作用机理的研究；二是建立在对第一个问题深刻理解的基础上，更好地设计和制备满足我们的需要的新颖小分子。围绕着细胞骨架、激酶、G蛋白偶联受体、离子通道等热点药物靶点蛋白，我们重点研究具有高活性和特异性的天然产物小分子和药物分子，发展和应用有机化学的新反应、新方法、新策略实现高效的化学合成、结构修饰和性质优化，并通过广泛的合作来开发新的分子探针和工具，为突变体蛋白的选择性抑制、蛋白-蛋白相互作用的精细调控等挑战性难题提供新的视角。

近期论文

1. Yu X., Xiao, L., Wang, Z., and Luo, T.* (2019) Scalable Total Syntheses of (-)-Vinigrol. J. Am. Chem. Soc. 141: 3440-3443.
2. Lu Y., Zhao S., Zhou S., Chen S.-C., and Luo, T.* (2019) Enantioselective Syntheses and Application of 4-epi-Galiellalactone and the Corresponding Activity-Based Probe: From Strained Bicycles to Strained Tricycles. Org. Biomol. Chem. 17: 1886-1892.
3. Su F., Lu Y., Kong L., Liu J., and Luo, T.* (2018) Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon. Angew. Chem., Int. Ed. 57: 760-764.
4. Guo Y., Quan T., Lu Y., and Luo T.* (2017) Enantioselective Total Synthesis of (+)-Wortmannin. J. Am. Chem. Soc. 139: 6815-6818.
5. Xiang H., Yao R., Quan T., Wang F., Chen L., Du X., Zhang W., Deng H., Xie D.*, and Luo T.* (2017) Simple β-Lactones are Potent Irreversible Antagonists for Strigolactone Receptors. Cell Res. 27: 1525-1528.
6. Zhang Y., Xue Y., Li G., Yuan H., and Luo T.* (2016) Enantioselective Synthesis of Iboga Alkaloids and Vinblastine via Rearrangements of Quaternary Ammoniums. Chem. Sci 7: 5530-5536.
7. Yu X., Su F., Liu C., Yuan H., Zhao S., Zhou Z., Quan T., and Luo, T.* (2016) Enantioselective Total Syntheses of Various Amphilectane and Serrulatane Diterpenoids via Cope Rearrangements. J. Am. Chem. Soc. 138: 6261-6270.
8. Zhao S., Dai J., Hu M., Liu C., Meng R., Liu X., Wang C., and Luo T.* (2016) Photo-induced Coupling Reaction of Tetrazoles and Carboxylic Acids in Aqueous Solution: Application in the Protein Labelling. Chem. Commun. 52: 4702-4705.