个人简历

黄岩谊课题组主要从事单细胞分析化学、微流控技术、高通量基因组测序技术的研究，并研发新型的生命分析化学仪器。他的研究团队通过融合生物技术、生物物理、计算机、分析化学等多个学科的技术进步，来实现对复杂生物体系的定量和高通量测量。在过去几年，黄岩谊课题组着重发展了纠错编码的新型 DNA 测序策略，提出了新的测序原理和提高测序原始准确率的新方法。同时，针对单细胞定量分析的新方法和新技术，包括在低拷贝数核酸检测上和在单细胞全基因组分析、全转录组分析和极少量细胞表观遗传组分析方面，实现了一系列重要技术突破。他们在集成微流控芯片、单细胞基因组分析技术与器件、单细胞定量化学成像分析方法方面的工作，可以很好地 将表现型和基因型及其动态调控很好的关联起来，在单细胞层次上对复杂体系进行多维度、高精度的测量分析，提供可靠数据并揭示功能相关性。

近期论文

1. Xiannian Zhang, Tianqi Li, Feng Liu, Yaqi Chen, Jiacheng Yao, Zeyao Li, Yanyi Huang,* Jianbin Wang*. Comparative analysis of droplet-based ultra-high-throughput single-cell RNA-seq systems. Molecular Cell 2019, 73, 130-142.
2. Zitian Chen, Wenxiong Zhou, ShuoQiao, Li Kang, HaifengDuan, X. SunneyXie, Yanyi Huang*. Highly accurate fluorogenic DNA sequencing with information theory-based error correction. Nature Biotechnology 2017, 35, 1170-1178.
3. Shengliang Li, Tao Chen, Yunxia Wang, Libing Liu, Fengting Lv, Zhiliang Li, Yanyi Huang,* Kirk S. Schanze,* Shu Wang*. Conjugated Polymer with Intrinsic Alkyne Units for Synergistically Enhanced Raman Imaging in Living Cells. Angewandte Chemie Int. Ed. 2017, 56, 13455-13458.
4. Zitian Chen, Peiyu Liao, Fangli Zhang, Mengcheng Jiang, Yusen Zhu, Yanyi Huang.* Centrifugal micro-channel array droplet generator for highly parallel digital PCR. Lab Chip 2017, 17, 235-240.
5. Yusi Fu, Chunmei Li, Sijia Lu, Wenxiong Zhou, Fuchou Tang, X. Sunney Xie,* Yanyi Huang.* Uniform and accurate single-cell sequencing based on emulsion whole-genome amplification. PNAS 2015, 112, 11923-11928.
6. Jie Shen, Dongqing Jiang, Yusi Fu, Xinglong Wu, HongshanGuo, Binxiao Feng, Yuhong Pan g, Aaron M. Streets, Fuchou Tang,* Yanyi Huang.* H3K4me3 epigenomic landscape derived from ChIP-Seq of 1,000 mouse early embryonic cells. Cell Res. 2015, 25, 143-147.
7. Aaron M. Streets, Xiannian Zhang, Chen Cao, Yuhong Pang, Xinglong Wu, Liang Xiong, Lu Yang, Yusi Fu, Liang Zhao,* Fuchou Tang,* Yanyi Huang.* Microfluidic single-cell whole transcriptome sequencing. PNAS 2014, 111, 7048-7053.