个人简历

教育背景 2003.9-2006.7 中国农业大学 生物学院 理学博士 2000.9-2003.7 东北师范大学 生命科学学院 理学硕士 工作经历 2015.12-2017.6 美国德州大学MD安德森癌症中心 访问学者 2014.7- 现在 北京交通大学理学院生命科学与生物工程研究院 副教授 2006.9-2014.6中科院生物物理研究所感染免疫中心 博士后，助理研究员，副研究员

研究领域

长期从事肿瘤微环境和肿瘤免疫方向研究。以多种转基因和基因敲除小鼠为模型，采用移植瘤和化学致癌等方法，结合临床研究： （1）肿瘤微环境的形成机制：炎症因子在炎-癌转变中的作用及分子机制；炎症因子在肿瘤生长及转移中的效应机制。 （2）肿瘤细胞与肿瘤间质细胞的相互作用：肿瘤间质成纤维细胞、巨噬细胞在肿瘤发生、生长、转移和化疗过程中的作用及分子机制。 （3）肿瘤分子标志物的筛选和鉴定及功能研究。

近期论文

1. Qi Yuan, Shasha Hou, Junfeng Zhai, Tian Tian, Yingjie Wu, Zhenlong Wu, Jinsheng He, Zhinan Chen and Jinhua Zhang*, S100A4 promotes inflammation but suppresses lipid accumulation via the STAT3 pathway in chronic ethanol-induced fatty liver，Journal of Molecular Medicine, 2019 July 18 https://doi.org/10.1007/s00109-019-01808-7 （IF=4.9）
2. Tian Tian, Xiaoyi Li and Jinhua Zhang * mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy .Int J Mol Sci.2019 Feb 11;20(3). pii: E755. doi: 10.3390/ijms20030755.（IF=3.69）
3. Rong Wu#, Ang Li#, Baofa Sun#, Jian-Guang Sun#, Jinhua Zhang#, Ting Zhang, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma , Xin Yang, Yajin Liao , Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang, Yun-Gui Yang and Zengqiang Yuan. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research, 2019, 29:23–41; https://doi.org/10.1038/s41422-018-0113-8 (IF=15.39)
4. Jinhua Zhang*, Shasha Hou, Jianchun Gu, Tian Tian, Qi Yuan, Junying Jia, Zhihai Qin, Zhinan Chen*, S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis. OncoImmunology, 2018 Jun 11;7(8):e1461301.(IF=5.5)
5. Jinhua Zhang，Kun Song，Jun Wang，Yanan Li，Shuangqing Liu，Chengliang Dai，Lieping Chen，Shengdian Wang，Zhihai Qin* ， S100A4 blockage alleviates agonisticanti-CD137 antibody-induced liver pathology without disruption of anti-tumor immunity，Oncoimmunoloy，2018 Jan 23;7(4):e1296996. (IF=5.5)
6. Jinhua Zhang, Gottumakkala S. Raju, David W. Chang, Shu-Hong Lin, Zhinan Chen, Xifeng Wu*. Global and targeted circulating miRNA profiling of colorectal adenoma and colorectal cancer. Cancer, 2018 ,124(4):785-796 (IF=6.54)
7. Jinhua Zhang, Yuanqing Ye, David W. Chang, Shu-Hong Lin, Maosheng Huang, Nizar M. Tannir, Surena Matin, Jose A. Karam, Christopher G. Wood, Zhinan Chen, Xifeng Wu*, Global and targeted microRNA expression profiling in clear cell renal cell carcinoma tissues potentially links miR-155-5p and miR-210-3p to both tumorigenesis and recurrence, American Journal of Pathology, 2018, Nov;188(11):2487-2496. (IF=4.02)
8. Shasha Hou, Tian Tian, Dianwen Qi, Kaiji Sun, Qi Yuan, Ziling Wang, Zhihai Qin, ZhenlongWu, Zhinan Chen and Jinhua Zhang*, S100A4 promotes lung tumordevelopment through β-catenin pathwaymediated autophagy inhibition. Cell Death and Disease, 2018, 9:277(IF=5.64)
9. Shasha Hou, Ying Jiao, Qi Yuan, Junfeng Zhai, Tian Tian, Kaiji Sun, Zhinan Chen, Zhenlong Wu, Jinhua Zhang*, S100A4 protects mice from high-fat diet-induced obesity and inflammation. Laboratory investigation, 2018, Aug;98(8):1025-1038. (IF=4.23)
10. Yingjie Wu#, Jinhua Zhang#, Yinghe Qin, S100A4 promotes the development of lipopolysaccharide-induced mouse endometritis, Biology of Reproduction，2018 Nov 1;99(5):960-967(IF=3.18)
11. Tian Tian, Ziling Wang, and Jinhua Zhang*，Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies, Oxidative medicine and cellular longevity, 2017;2017:4535194.(IF=4.94)
12. Jinhua Zhang*, Ying Jiao, Shasha Hou, Tian Tian, Qi Yuan, Huaijie Hao, Zhenlong Wu, Xuexiang Bao. S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells. Scientific Reports, 2017 Sep 21;7(1):12099 (IF=4.12)
13. Jianchun Gu，Dong Liang，Jeanne A Pierzynski，Yuanqing Ye，Jinhua Zhang， Jaffer A.Ajani，Xifeng Wu ， D-mannose: a novel prognostic biomarker for patients with esophageal adenocarcinoma，Carcinogenesis，2017.01.06，38（2）：162~167 (IF=5.07)
14. Lin Chen, Jie Li, Jinhua Zhang, Chengliang Dai, Xiaoman Liu, Jun Wang , Zhihai Qin. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. Journal of Hepatology, 2015,62:156–164 (IF=15.04)
15. Jinhua Zhang, Lin Chen, Xiaoman Liu and Zhihai Qin*, Fibroblast-Specific Protein 1/S100A4–Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens, Cancer Research, 2013, 73:2770-2781 (IF=9.13)
16. Jinhua Zhang, Lin Chen, Mingjie Xiao, Chunhui Wang and Zhihai Qin, FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. American Journal of Pathology, 178:382-390, 2011 (IF=4.02)
17. Jiangmei Li, Yu Lu, Jinhua Zhang, Hua Kang, Zhihai Qin and Chang Chen, PI4KIIα is a novel regulator of tumor growth by its action on angiogenesis and HIF-1α regulation. Oncogene, 29:2550-2559, 2010 (IF=6.85)
18. Zibing Wang, Jing Jiang, Zhiguang Li, Jinhua Zhang, Hui Wang and Zhihaiqin, A myeloid cell population induced by Freund’s adjuvant suppresses T cell-mediated anti-tumor immunity. Journal of immunotherapy, 33:167-177, 2010 (IF=3.83)
19. Jing Jiang, Zibing Wang, Zhiguang Li, Jinhua Zhang, Xiaopu Zhao and Zhihai Qin, Early exposure of high-dose interleukin-4 to tumor stroma reverses myeloid cell-mediated T-cell suppression. Gene therapy, 17: 991-999, 2010 (IF=3.2)
20. Mingjie Xiao, Chunhui Wang, Jinhua Zhang, Zhiguang Li, Xueqiang Zhao and Zhihai Qin, IFNγ promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Research, 69:2010-2017, 2009(IF=9.13)