个人简历

教育背景 2003年9月-2006年7月 中国协和医科大学基础所免疫学专业获理学博士学位 工作经历 2010年10月至今 北京交通大学副教授、硕士研究生导师（2013年为美国Northwestern University访问学者） 2006年9月-2010年9月 北京交通大学理学院讲师

研究领域

长期从事阿尔茨海默病（Alzheimer's disease, AD）发病机制、早期诊断和免疫防治的基础研究： （1）阿尔茨海默病基因工程抗体药物、老年性痴呆风险基因筛选和诊断试剂研究。 （2）AD等神经退行性疾病细胞死亡与再生的调控机制研究。 （3）生物电镜的基础和应用、组织病理超微结构、生物大分子结构研究。

近期论文

1. Li JT, Zhang Y*. TREM2 regulates innate immunity in Alzheimer's disease. J Neuroinflammation. 2018, 15(1):107. doi: 10.1186/s12974-018-1148-y.

2. Jie Wen#, Fang Fang#, Shu-Han Guo#, Ying Zhang*, Xiang-Lei Peng, Wei-Min Sun, Xiao-Ran Wei, Jin-Sheng He, Tao Hung, Amyloid b-Derived Diffusible Ligands (ADDLs) Induce Abnormal Autophagy Associated with Ab Aggregation Degree, Journal of Molecular Neuroscience, 2018, 64(2):162-174. doi: 10.1007/s12031-017-1015-9. Epub 2017 Dec 19

3.Zhi-Qiang Du, Ying Zhang, Liming Li. [SWI+] abolishes yeast multicellular growth by triggering conformational changes of multiple regulators required for flocculin gene expression. Cell Reports, 2015, 13(12) : 2865-78

4. Ying Zhang#*, Hai-Qiang Yang#, Fang Fang, Lin-Lin Song, Yue-Ying Jiao, He Wang, Xiang-Lei Peng, Yan-Peng Zheng, Jun Wang, Jin-Sheng He, Tao Hung. Single chain variable fragment against Aβ expressed in baculovirus inhibits abeta fibril elongation and promotes its disaggregation. PLOS ONE. 2015, 10(4):e0124736

5. Xiang-Lei Peng#, Lei Hou#, Shao-Hua Xu, Ying Hua, Shu-Jie Zhou, Ying Zhang, Yan-Peng Zheng, Yuan-Hui Fu, Qing Xu, Li-Shu Zhang, Jun Wang, Xiao-Ting Guan*, Jin-Sheng He*, Novel APP K724M mutation causes Chinese early-onset familial Alzheimer's disease and increases amyloid-β42 to amyloid-β40 ratio, Neurobiol Aging, 2014, 35(11):2657.e1-6

6. Ying Zhang, Tao Hung, Jingdong Song, Jinsheng He. Electron Microscopy: Essentials for Viral Structure, Morphogenesis and Rapid Diagosis. SCIENCE CHINA Life Sciences, 2013, 56 (5): 421-430

7. Ying Zhang, Jin-Sheng He, Xin Wang, Jun Wang, Fu-Xiang Bao, Wei-Min Sun, Si-Yuan Pang, Fan Yin, Hong-Gang Hu, Xiang-Lei Peng, Yan-Peng Zheng, Ling-Ling Hou, Tao Hong. Administration of Ab42 Oligomers Specific Monoclonal Antibody Improved Memory Performance in SAMP8 Mice. J Alzheimer Dis，2011, 23 (3): 551-561.

8. Ying Zhang, Xin Wang, Jin-sheng He, Fu-Xiang Bao, Wei-Min Sun, Xin-Xian Dai, Xiao-Bo Wang, Yi-Qin Li, Xian-Xian Zheng, Hong-Gang Hu, Xiang-Lei Peng, Yan-Peng Zheng, Ling-Ling Hou, Tao Hong. Preparation and Characterization of a Monoclonal Antibody with High Affinity for Soluble Ab Oligomers. Hybridoma, 2009, 28 (5): 349-354

9. He Jin-Sheng*#, Ying Zhang #, Hong Tao. Progress in the development of therapeutic antibodies targeting prion proteins and b-amyloid peptides. SCIENCE CHINA Life Sciences, 2010, 53 (8): 959-963 (#contributed equally)
10. Ying Zhang，He Jin-sheng, Guo Shu-han, et al. Morphologic and Structural Dynamic Features of Ab42 Aggregation in Vitro. Neural Regen Res, 2011, 6: 335-339 .