个人简历

教育与工作经历\r
1998-2003\t北京大学\t临床医学检验/本科\r
2003-2008\t中科院生物物理所\t生物化学与分子生物学/博士\r
2008-2012\t北航生物与医学工程学院\t讲师\r
2012\t香港理工大学\t助理研究员\r
\t 医疗科技及资讯学系\t\r
2018-2019\t美国哥伦比亚大学\t访问学者\r
2012-2021\t北航生物与医学工程学院\t副教授\r
2021-今\t北航生物与医学工程学院\t教授\r
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主要学术获奖\r
入选北京高等学校“青年英才计划”（2013）\r
北京航空航天大学“蓝天新星”称号（2012）\r
北京航空航天大学“蓝天新秀”称号（2009）\r
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主要教学获奖\r
北京市高等教育教学成果奖二等奖（2018）\r
“挑战杯”首都大学生课外学术科技作品竞赛优秀指导老师 (2017)\r
全球工程医疗创新竞赛铜奖指导教师 (2017)\r
北航教学优秀奖二等奖 (2017)\r
第十六届“我爱我师”优秀教师 (2017)\r
校级优秀班主任 (2015)\r
北京航空航天大学教学成果奖二等奖 (2014)\r

研究领域

骨与口腔力学生物学\r
生物材料调控干细胞分化机理研究\r
物理因子调控组织再生及机制研究""

近期论文

J Na, LY Zhang, LS Zheng*, JY Jiang, QS Shi, CY Li, YB Fan*. Static magnetic feld regulates proliferation, migration, and diferentiation of human dental pulp stem cells by MAPK pathway[J]. Cytotechnology.2022,Accepted.\r
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J Na, LS Zheng*, LJ Wang, QS Shi, ZJ Yang, N Liu, YW Guo, YB Fan*. Phenytoin Regulates Migration and Osteogenic Differentiation by MAPK Pathway in Human Periodontal Ligament Cells [J]. Cell Mol Bioeng. 2022;15(1):151-160.\r
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LS Zheng, QS Shi, J Na, N Liu, YW Guo, YB Fan. Platelet-Derived Growth Factor Receptor-alpha and beta are Involved in Fluid Shear Stress Regulated Cell Migration in Human Periodontal Ligament Cells [J]. Cell Mol Bioeng. 2019;12(1):85-97.\r
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Y Huang, HK Deng, YB Fan, LS Zheng, JF Che, XM Li, KE Aifantis. Conductive nanostructured Si biomaterials enhance osteogeneration through electrical stimulation [J]. Materials Science & Engineering C-Materials for Biological Applications. 2019;103.\r
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LS Zheng, LS Zhang, LP Chen, JY Jiang, XC Zhou, M Wang, YB Fan. Static magnetic field regulates proliferation, migration, differentiation, and YAP/TAZ activation of human dental pulp stem cells [J]. J Tissue Eng Regen Med. 2018;12(10):2029-2040. (封面论文)\r
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LS Zheng, JY Jiang, JP Gui, LY Zhang, XY Liu, Y Sun, YB Fan. Influence of Micropatterning on Human Periodontal Ligament Cells' Behavior [J]. Biophys J. 2018;114(8):1988-2000.\r
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SA Xie, T Zhang, J Wang, F Zhao, YP Zhang, WJ Yao, SS Hur, YT Yeh, W Pang, LS Zheng, YB Fan, W Kong, X Wang, JJ Chiu, J Zhou. Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1 [J]. Biomaterials. 2018;155:203-216.\r
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LS Zheng, LP Chen, JP Gui, Q Li, Y Huang, ML Liu, XL Jia, W Song, J Ji, XH Gong, RS Shi, YB Fan. The effects of fluid shear stress on proliferation and osteogenesis of human periodontal ligament cells [J]. J Biomech. 2016;49(4):572-579. (亮点关注)\r
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LP Chen, LS Zheng*, JY Jiang, JP Gui, LS Zhang, Y Huang, XF Chen, J Ji, YB Fan*. Calcium Hydroxide-induced Proliferation, Migration, Osteogenic Differentiation, and Mineralization via the Mitogen-activated Protein Kinase Pathway in Human Dental Pulp Stem Cells [J]. J Endod. 2016;42(9):1355-1361.\r
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LS Zheng, YT Liu, L Chen, Y Wang, YN Rui, HZ Huang, SY Lin, J Wang, ZX Wang, SC Lin, JW Wu. Structure and mechanism of the unique C2 domain of Aida [J]. FEBS J. 2014;281(20):4622-4632.\r
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XM Li, Y Huang, LS Zheng, HF Liu, XF Niu, J Huang, F Zhao, YB Fan. Effect of substrate stiffness on the functions of rat bone marrow and adipose tissue derived mesenchymal stem cells in vitro [J]. J Biomed Mater Res A. 2014;102(4):1092-1101.\r
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XH Gong, HF Liu, XL Ding, ML Liu, X Li, LS Zheng, XL Jia, G Zhou, YW Zou, JC Li, XJ Huang, YB Fan. Physiological pulsatile flow culture conditions to generate functional endothelium on a sulfated silk fibroin nanofibrous scaffold [J]. Biomaterials. 2014;35(17):4782-4791.\r
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ML Liu, W Song, P Li, Y Huang, XH Gong, G Zhou, XL Jia, LS Zheng, YB Fan. Galanin protects against nerve injury after shear stress in primary cultured rat cortical neurons [J]. PLoS One. 2013;8(5):e63473.\r
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XL Jia, JY Yang, W Song, P Li, X Wang, CD Guan, L Yang, Y Huang, XH Gong, ML Liu, LS Zheng, YB Fan. Involvement of large conductance Ca(2+)-activated K (+) channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation [J]. Pflugers Arch. 2013;465(2):221-232.\r
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LS Zheng, YY Zhang, JW Wu, ZWu, ZY Zhang, ZX Wang. A continuous spectrophotometric assay for mitogen-activated protein kinase kinases [J]. Anal Biochem. 2012;421(1):191-197.\r
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LS Zheng, Y Huang, W Song, XH Gong, ML Liu, XL Jia, G Zhou, LP Chen, A Li, YB Fan. Fluid shear stress regulates metalloproteinase-1 and 2 in human periodontal ligament cells: involvement of extracellular signal-regulated kinase (ERK) and P38 signaling pathways [J]. J Biomech. 2012;45(14):2368-2375.\r
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Y Huang, LS Zheng, XH Gong, XL Jia, W Song, ML Liu, YB Fan. Effect of cyclic strain on cardiomyogenic differentiation of rat bone marrow derived mesenchymal stem cells [J]. PLoS One. 2012;7(4):e34960.\r
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L Chen, ZH Jiao, LS Zheng(共同第一作者), YY Zhang, ST Xie, ZX Wang, JW Wu. Structural insight into the autoinhibition mechanism of AMP-activated protein kinase [J]. Nature. 2009;459(7250):1146-1149.\r
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石秋生,纳静,杨智杰,李心杨,陈鑫远,武弋,樊瑜波,郑丽沙.剪切力通过p38-YAP/TAZ通路调节人牙周膜细胞增殖[J].医用生物力学,2021,36(S1):203.\r
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李驰宇,郭雨薇,纳静,杨智杰,宋亚欣,樊瑜波,郑丽沙.细胞形状调控人牙髓干细胞干性维持及其机制研究[J].医用生物力学,2021,36(S1):90.\r
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陈罗萍,郑丽沙,樊瑜波.Wnt信号通路对氢氧化钙促进人牙髓干细胞成骨向分化的调控[J].国际生物医学工程杂志,2019(02):120-124.\r
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张灵玉,江静怡,樊瑜波,郑丽沙.磁场在骨生物学领域:研究与应用中明确和未明确问题[J].中国组织工程研究,2019,23(04):584-590.\r
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张泽茜,伍佳琪,樊瑜波,郑丽沙.干细胞心肌向分化成熟过程中的物理刺激方法[J].中国组织工程研究,2019,23(01):110-117.\r
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江静怡,樊瑜波,郑丽沙.力学因素对间充质干细胞神经向分化的影响[J].中国组织工程研究,2018,22(17):2761-2768.\r
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桂金鹏,江静怡,张灵玉,纳静,樊瑜波,郑丽沙.力学因素对细胞自噬的影响[J].中国组织工程研究,2017,21(12):1946-1952.\r
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黄天辉,桂金鹏,郑丽沙.利用酶制剂改善再造烟叶品质研究进展[J].东北农业大学学报,2015,46(10):102-108.\r
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陈罗萍,张桂荣,郑丽沙,黄燕,樊瑜波.流体剪切力对成骨细胞LEF-1蛋白表达的影响[J].现代生物医学进展,2013,13(22):4230-4232\r
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周钢,孙艳,李萍,郑丽沙,宋崴,牛旭锋,刘文勇,刘美丽,樊瑜波,杨欣.生物医学工程专业微生物实验课程体系改革与实践[J].实验室研究与探索,2012,31(10):95-97.\r
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郑丽沙,李德玉,荣龙,周钢,樊瑜波.面向非生物专业本科生的“生命科学导论”教学改革初步探索[J].重庆工商大学学报(自然科学版),2012,29(07):112-114.\r
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陈雷,焦智浩,郑丽沙,张媛媛,解树涛,王志新,吴嘉炜.糖尿病关键蛋白AMPK的自抑制机制[J].生物物理学报,2009,25(S1):97.\r
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郑丽沙,陈雷,王盈,王大成,王志新,林圣彩,吴嘉炜. Axin相关蛋白Aida的结构及功能研究[C].第九届全国酶学学术讨论会暨邹承鲁诞辰85周年纪念会论文摘要集,2008:96.
中国生物医学工程学会 会员
中国生物材料学会 会员
中国细胞生物学学会 会员