个人简历

2013.08-至今, 研究员，博士生导师，北京大学化学与分子工程学院\r
2013.08-至今, PI，北京大学软物质科学与工程中心\r
2011.09-2013.08, 博士后，美国加州理工学院（导师：Prof. David A. Tirrell）\r
2010.06-2011.08, 博士后，美国阿克伦大学高分子科学系（导师：Prof. Stephen Z. D. Cheng）\r
2006.01-2010.05, 理学博士，美国阿克伦大学高分子科学系（导师：Prof. Stephen Z. D. Cheng and Prof. Roderic P. Quirk）\r
2000.09-2004.06, 理学学士，北京大学化学与分子工程学院

研究领域

"""""本课题组致力于集成合成高分子和生物高分子的独特基元和设计理念，发展具有不寻常结构和性质的精密结构大分子，并探索其在生物医药领域的应用。\r
蛋白质拓扑工程及其生物医学应用\r
巨型分子杂化体系的精准合成、可控组装和功能化\r
生物大分子的催组装和系统化学"

近期论文

Wang, X.-W.; Zhang, W.-B.* Chemical Topology and Complexity of Protein Architectures. Trends Biochem. Sci. 2018, 43, 806-817.\r
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Wu, X.-L.;# Liu, Y.;# Liu, D.; Sun, F.; Zhang, W.-B.* An Intrinsically Disordered Peptide-Peptide Stapler for Highly Efficient Protein Ligation Both in vivo and in vitro. J. Am. Chem. Soc. 2018, 140, 17474–17483.\r
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Wu, W.-H.; Wei, J.; Zhang, W.-B.* Controlling SpyTag/SpyCatcher Reactivity via Redox-Gated Conformational Restriction. ACS Macro Lett. 2018, 7, 1388-1393.\r
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Wang, X.-M.;# Shao, Y.;# Jin, P.-F.; Jiang, W.; Hu, W.; Yang, S.; Li, W.;* He, J.;* Ni, P.; Zhang, W.-B.* Influence of Regio-Configuration on the Phase Diagrams of Double-Chain Giant Surfactants. Macromolecules 2018, 51, 1110-1119.\r
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Wang, X.-W.; Zhang, W.-B.* Protein Catenation Enhances Both Stability and Activity of Folded Structural Domains. Angew. Chem. Int. Ed. 2017, 56, 13985-13989.\r
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Liu, Y.;# Liu, D.;# Yang, W.;# Wu, X.-L.; Lai, L.;* Zhang, W.-B.* Tuning SpyTag-SpyCatcher Mutant Pairs toward Orthogonal Reactivity Encryption. Chem. Sci. 2017, 8, 6577-6582.\r
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Liu, D.; # Wu, W.-H.; # Liu, Y.-J.; Wu, X.-L.; Cao, Y.; Song, B.; Li, X.; Zhang, W.-B.* Topology Engineering of Proteins in Vivo Using Genetically Encoded, Mechanically Interlocking SpyX Modules for Enhanced Stability. ACS Cent. Sci. 2017, 3, 473–481.\r
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Wang, X.-W.; Zhang, W.-B.* Cellular Synthesis of Protein Catenanes. Angew. Chem. Int. Ed. 2016, 55, 3442-3446.\r
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Yue, K.; # Huang, M.; # Marson, R.L.; # He, J.; Huang, J.; Zhou, Z.; Wang, J.; Liu, C.; Yan, X.; Wu, K.; Guo, Z.; Liu, H.; Zhang, W.; Ni, P.; Wesdemiotis, C.; Zhang, W.-B.;* Glotzer, S. C.;* Cheng, S. Z. D.* Geometry induced sequence of nanoscale Frank–Kasper and quasicrystal mesophases in giant surfactants. Proc. Natl. Acad. Sci. USA 2016, 113, 14195-14200.\r
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Huang, M.; Hsu, C.-H.; Wang, J.; Mei, S.; Dong, X.; Li, Y.; Li, M.; Liu, H.; Zhang, W.; Aida, T.; Zhang, W.-B.;* Yue, K.;* Cheng, S. Z. D.* Selective-Assemblies of Giant Tetrahedra via Precisely Controlled Positional Interactions. Science, 2015, 348, 424-428.