个人简历

教育经历: 1978 - 1980 , 理学硕士 , 细胞及发育生物学专业 , 中国科学院研究生院 1959 - 1965 , 理学学士 , 人体及动物生理专业 , 北京大学生物系 工作经历: 2000 - 2007 , 副主任 , 国家自然科学基金委 2000 - 至今 , 教授 , 北京大学生命科学学院 遗传与发育中心主任 1991 - 1994 , 高级讲师 , 英国阿伯丁大学 1989 - 至今 , 研究员 , 中国科学院水生生物研究所 所长/国家淡水生态与生物技术重点实验室主任（1995-99） 1988 - 1991 , 教授研究员 , 美国马里兰大学海洋生物技术中心 1984 - 1984 , Hill-访问教授 , 美国明尼苏达大学 1982 - 1983 , 访问学者 , 美国波士顿遗传研究所 1981 - 1982 , 访问学者 , 英国伦敦帝国肿瘤研究所

研究领域

1.主持北京大学遗传与发育生物学研究中心，以斑马鱼、果蝇、线虫等模式动物为材料，探索动物发育调控的分子机制以及相关的疾病模型的研究：规模性筛选和鉴定模式动物发育相关基因；研究基因表达图式及其在发育中的功能和可能的致病机制；从分子水平研究细胞分化与发育的调控机制。2.以水生脊椎动物为材料，通过显微操作技术，探索发育过程中的核质关系以及胞质因子对发育和形态建成的影响。

近期论文

1. Pengpeng Liu, Lijiang Long, Kai Xiong, Bo Yu, Nannan Chang, Jing-Wei Xiong, Zuoyan Zhu and Dong Liu , Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system , Cell Research , 2014 , 24(7): 886-9 2. Shilin Song, Yuan Yuan, Jinfeng Lu, Qi Li, Zuoyan Zhu, Qichang Fan, Youfang Xue, Zhi-Chun Lai and Wenxia Zhang , The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling , Dev Biol. , 2013 , 380: 344-350 3. Min Liu, Pengpeng Liu, Li Zhang, Qingchun Cai, Ge Gao, Wenxia Zhang, Zuoyan Zhu, Dong Liu and Qichang Fan , mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans , Cell Research , 2011 , 21: 1605-1618 4. Zheng Li, Min Liu, Li Zhang, Wenxia Zhang, Ge Gao, Zuoyan Zhu, Liping Wei, Qichang Fan and Manyuan Long , Detection of intergenic non-coding RNAs expressed in the main developmental stages in Drosophila melanogaster , Nucleic Acids Research , 2009 , 37: 4308-4314 5. Xiangming Wang, Min Liu, Weida Li, Christopher D. Suh, Zuoyan Zhu, Yishi Jin and Qichang Fan , he Function of a Spindle Checkpoint Gene bub-1 in C. elegans Development , PLoS ONE , 2009 , 4: e5912 6. Wen, Lu, Wei, Wei, Wenchao Gu, Peng Huang, Xi Ren, Zheng Zhang, Zuoyan Zhu, Shuo Lin and Bo Zhang , Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish , Developmental Biology , 2008 , 314: 84-92 7. Dongmei Wang, Li-En Jao, Naizhong Zheng, Kyle Dolan, Jessica Ivey, Seth Zonies†, Xiaolin Wu, Kangmai Wu, Hongbo Yang, Qingchao Meng, Zuoyan Zhu, Bo Zhang, Shuo Lin*, and Shawn M. Burgess , Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions , PNAS , 2007 , 104(30):12428-12433 8. Dongmei Wang, Li-En Jao, Naizhong Zheng, Kyle Dolan, Jessica Ivey, Seth Zonies†, Xiaolin Wu, Kangmai Wu, Hongbo Yang, Qingchao Meng, Zuoyan Zhu, Bo Zhang, Shuo Lin*, and Shawn M. Burgess , Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions , PNAS , 2007 , 104(30):12428-12433 9. 4. Hanbing Zhong, Xinrong Wu, Haigen Huang, Qichang Fan, Zuoyan Zhu, and Shuo Lin , Vertebrate MAX-1 is required for vascular patterning in zebrafish , Proc Natl Acad Sci U S A , 2006 , 103(45): 16800–16805 10. 5. Jun-zheng Zhang,Wei Gao,Hong-Bo Yang, Bo Zhang, Zuo-yan Zhu and You-fang Xue , Screening for Genes Essential for Mouse Embryonic Stem Cell Self-Renewal Using a Substractive RNA Interference Library , Stem cell , 2006 , 24;2661-2668 11. 4. Hanbing Zhong, Xinrong Wu, Haigen Huang, Qichang Fan, Zuoyan Zhu, and Shuo Lin , Vertebrate MAX-1 is required for vascular patterning in zebrafish , Proc Natl Acad Sci U S A , 2006 , 103(45): 16800–16805 12. 5. Jun-zheng Zhang,Wei Gao,Hong-Bo Yang, Bo Zhang, Zuo-yan Zhu and You-fang Xue , Screening for Genes Essential for Mouse Embryonic Stem Cell Self-Renewal Using a Substractive RNA Interference Library , Stem cell , 2006 , 24;2661-2668 13. Sun YH, Chen SP, Wang YP, Hu W, Zhu ZY , Cytoplasmic impact on cross-genus cloned fish derived from transgenic common carp (Cyprinus carpio) nuclei and goldfish (Carassius auratus) enucleated eggs , Biology of Reproduction , 2005 , 72: 510-515 14. Sun YH, Chen SP, Wang YP, Hu W, Zhu ZY , Cytoplasmic impact on cross-genus cloned fish derived from transgenic common carp (Cyprinus carpio) nuclei and goldfish (Carassius auratus) enucleated eggs , Biology of Reproduction , 2005 , 72: 510-515 15. Zhu ZY, He L and Chen TT , Primary-structural and evolutionary analyses of the growth-hormone gene from grass carp (Ctenopharyngodon idellus) , Eur. J. Biochem. , 1992 , 207: 643-648 16. Zhu ZY, He L and Chen TT , Primary-structural and evolutionary analyses of the growth-hormone gene from grass carp (Ctenopharyngodon idellus) , Eur. J. Biochem. , 1992 , 207: 643-648 17. Zhu ZY, Li G, He L and Chen S, , Novel gene transfer into the fertilized eggs of goldfish (Carassius auratus L.1758) , Z.angew.Ichthyol. , 1985 , 1: 31-34 18. Zhu ZY, Li G, He L and Chen S, , Novel gene transfer into the fertilized eggs of goldfish (Carassius auratus L.1758) , Z.angew.Ichthyol. , 1985 , 1: 31-34