个人简历

分别于1992、1998、2006年在北京大学药学院获得学士、硕士及博士学位。曾到香港理工大学(2002-2004)和美国奥克拉荷马州立大学(2007-2008)作访问研究。1998年后在北京大学药学院药剂学系工作。长期从事定量药理学以及药物代谢酶相关研究和应用，是北京大学/辉瑞公司定量药理学高级培训中心核心成员。现任北京大学药学院教授、博士生导师，中国药理学会定量药理学专业委员会委员，国家自然科学基金及北京市等省部级自然科学基金评审专家，国家食品与药品管理局新药评审专家，中国临床药理学与治疗学杂志编委，以及10余个国内外相关专业期刊的评审。主持多项国家自然科学基金及北京市/教育部自然科学基金项目。发表论文90余篇，编写教材与专著6部，申请专利5项。主讲课程有本科生《生物药剂学与药物动力学》以及研究生《高等药物动力学》。

研究领域

定量药理学（主要包括基于机制的药物动力学/药效动力学(PK/PD)，群体药物动力学）；药物代谢酶诱导机理及功能。

近期论文

1.Pharmacometrics (including Mechanism-based Pharmacokinetics/ pharmacodynamics and Population Pharmacokinetics) 2.Functions and regulation mechanisms of drug metabolizing enzymes. Selected Publications 1.Li, J; Chen, R; Yao, QY; Liu, SJ; Tian, XY; Lu, W*; Zhou, TY*. Semi-mechanism-based pharmacokinetic-pharmacodynamic model for characterizing time-dependent pharmacokinetics of dexamethasone and its efficacy in the treatment of breast cancer. Acta Pharmacol Sin. 2018, online. 2.Chen, WJ; Chen, R; Li, J; Fu, Y; Yang, L; Su, H; Yao, Y; Li, L;Zhou, TY*; Lu, W*. Pharmacokinetic/Pharmacodynamic Modeling of Schedule-Dependent Interaction between Docetaxel and Cabozantinib in Human Prostate Cancer Xenograft Models. J Pharmacol Exp Ther . 2018, 364(1), 13-25. 3.Hao, FR; Wang, SY; Zhu, X; Xue, JS; Li, JY; Wang, LJ; Li, J Lu, W; Zhou, TY*. Pharmacokinetic- pharmacodynamic modeling of the anti-tumor effect of sunitinib combined with dopamine in the human non-small cell lung cancer xenograft. Pharm Res. 2017, 34, 408-418. 4.Li, J; Yao, QY; Xue, JS; Wang, LJ; Yuan, Y; Tian, XY; Su, H; Wang, SY; Chen, WJ; Lu, W*;Zhou, TY*. Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer. Acta Pharmacol Sin. 2017, 38(9), 1282-1296. 5.Yao, QY; Li, J; Yao,Y; Chen, R; Chen, WJ; Su, H, Yang, L; Xue, JS; Lu, W; Zhou, TY*. A highly sensitive LC-MS/MS method for the determination of 21-hydroxy deflazacort in nude mice plasma and its application to a pharmacokinetic study. J Chinese Pharm Sci . 2017, 26(6), 404-412. 6.Li, JY; Ren, YP; Yuan, Y; Ji SM; Zhou, SP; Wang, LJ; Mou Z; Li, L; Lu, W, Zhou, TY*. Preclinical PK/PD model for combined administration of erlotinib and sunitinib in the treatment of A549 human NSCLC xenograft mice. Acta Pharmacol Sin. 2016, 37(7), 930-940. 7.Wang, LJ; Li, J; Hao, FR; Yuan, Y; Li, JY; Lu, W;Zhou, TY*. Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen. Acta Pharmacol Sin. 2016, 37(6), 845-856. 8.Ji, XW; Ji, SM; Li, RT; Wu, KH; Zhu, X; Lu, W*; Zhou, TY*. Pharmacokinetic-pharmacodynamic modeling of the antitumor effect of TM208 and EGFR-TKI resistance in breast cancer. Acta Pharmacol Sin, 2016, 37(6). 825-833. 9.Li, X; Chen Y; Zhao W; Lu, W*; Zhou, TY*. Pharmacokinetic/Pharmacodynamic Analysis of Metformin using Different in Diabetic Rats. Drug Res. 2016, 66(10), 547-554. 10. Mou, ZZ; Wang, SY; Su, QH; Yuan, Y; Li, JY; Wang, LJ; Yao, QY; Ji, SM; Lu, W*; Zhou, TY*. Cabozantinib enhances the response of NSCLC cells with wild-type EGFR to erlotinib and pharmacodynamic modeling of their sequential combinations. J Chinese Pharm Sci. 2016, 25(11), 799-813. 11. Hua, M; Ji, XW; Li, RT; Ji, SM; Li, J; Yao, QY; Wang, LJ; Hao, FR; Lu, W; Zhou, TY*. Pharmacokinetic-pharmacodynamic modeling of the anticancer effect of TM208 on non-small cell lung cancer xenograft. J Chinese Pharm Sci. 2016, 25(7), 502-511. 12. Ma, YH; Li, J; Su, QH; Chen, WJ; Lu, W*; Zhou, TY*. A liquid chromatography-tandem mass spectrometric method for the determination of axitinib in nude mouse plasma: Development, validation and application to a pharmacokinetic study, J Chinese Pharm Sci. 2016, 25(5), 342-350. 13. Yuan, Y; Zhou, X; Ren, YP; Zhou, SP, Wang, LJ; Ji, SM; Hua, M; Li L; Lu, W; Zhou, TY*. Semi-Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for the Combination Use of Dexamethasone and Gemcitabine in Breast Cancer. J Pharm Sci . 2015, 104(12), 4399–4408. 14. Ji, XW; Chen, GP; Song, Y; Hua, M; Wang, LJ; Li, L; Yuan, Y; Wang, SY; Zhou, TY*; Lu, W. Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208. Acta Pharmacol Sin. 2015, 36(10), 1246-55. 15. Wang, SY; Mou, ZZ; Ma, YH; Li, J; Li, JY; Ji, XW; Wu, KH; Li, L; Lu, W; Zhou, TY*. Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: involvement of eradicating cancer stem-like cells. Biochem Pharmacol. 2015, 95(2), 98-109. 16. Ji, XW; Zhou, TY; Lu, Y; Wei, MJ, Lu; W; Cho, William Cs. Breast cancer treatment and sulfotransferase. Expert Opinion on Therapeutic Targets. 2015, 19(6), 821-34. 17. Li, J; Yuan, Y; Fan, R; Su, QH; Wang, SY; Zhou, TY*; Lu, W. A Simple LC/MS/MS Method for the Determination of Moxifloxacin N-Sulfate in Rat Plasma and Its Application in a Pharmacokinetic Study. J AOAC INT . 2015, 98(4), 921-926.