个人简历
学历：1984-1988毕业于北京大学化学系，获理学学士学位。1988-1994毕业于北京大学化学系分析化学专业，获理学博士学位。工作经历： 1994-1996，在北京医科大学药学院无机化学教研室从事博士后研究工作。1997-2000，在美国堪萨斯大学药学院药物化学系，从事博士后研究工作。2000.8回国在北京大学医学部药学院化学生物学系工作，2003年晋升教授，2006-2010年担任化学生物学系副主任。
研究领域
代谢性疾病（心血管病、脑神经退行性病变、骨质疏松、糖尿病等）相关的金属代谢和细胞信号转导 细胞的活性氧代谢、抗氧化响应机制和重金属排除 无机和矿物中药的结构-ADMET定量关系（QSPR）研究 从食物和中药中发现和开发肿瘤和代谢性疾病的化学预防药物
近期论文
(1) Wang N, Wang Z, Niu X, Yang X, Synthesis, characterization and anti-diabetic therapeutic potential of novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes, J. Inorg. Biochem., 2015, 152: 104–113 (2) Wang X, Lei R, Huang H, Wang N, Yuan L, Xiao R, Bai L, Li X, Li L, Yang, X，The permeability and transport mechanism of graphene quantum dots (GQDs) across the biological barrier, Nanoscale, 2015, 7: 2034 - 2041 (3) Huang M., Wu Y, Wang N, Wang Z, Zhao P, Yang X, Is the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding? Biol Trace Elem Res, 2014, 157/3:242-248 (4) Yaling Wu, Meiling Huang, Pan Zhao, Xiaoda Yang，Vanadyl acetylacetonate upregulates PPARγand adiponectin expression in differentiated rat adipocytes，JBIC，2013, 18/6: 623-631 (5) Zhao P, Yang X, Vanadium compounds modulate PPARγactivity primarily by increasing PPARγprotein levels in mouse insulinoma NIT-1 cells, Metallomics, 2013, 5(7): 836-43 (6) Xu Z, Zhang CY, Zhang Y, Yang X, Europium complexes as novel indicators of paracelluar diffusion, Chem. Biodiver., 2012, 9:1916-1922 (7) Gao, Z, Zhang, C, Yu, S, Yang, X, Wang, K, Vanadyl bis-acetylacetonate protected βcell from palmitate-induced cell death through unfolded protein response pathway, J.Biol.Inorg.Chem., 2011, 16/5: 789-798 (8) Wei, Y, Zhang, C, Zhao, P, Yang, X, Wang, K, A new salicylic acid-derivatised kojic acid vanadyl complex: Synthesis, Characterization and Anti-diabetic Therapeutic Potential, J. Inorg. Biochem. 2011, 105: 1081–1085 (9) Xia, Q., Feng X-D., Yuan, L., Wang, K., Yang, X., Brain derived neutotrphic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co cultures, Sci China Chem, 2010, 53: 2193-2199 (10) Zhao Y, Ye L, Liu H, Xia Q, Zhang Y, Yang X, Wang K., Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress, J. Inorg. Biochem., 2010, 104(4): 371-8 (11) Tian, XJ., Yang, XW., Yang, X., Wang, K., Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model, Int. J. Pharm., 2009, 367: 58–64 (12) Shen, C., Li, Z., Yang, X., Wang, K., La3+ binds to BiP/GRP78 and induces unfolded protein response in HepG2 cells, Chem-Biol. Interact., 2008, 176: 196-203 (13) Li, M, Li, Y, Chen, J, Wei, W, Pan, X, Liu, J, Liu, Q, Leu, W, Zhang, L, Yang, X, Lu, J, Wang, K, Copper ions inhibit S-Adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor, Biochemistry, 2007, 46, 11451-11458 (14) Yu, S., Hu, J., Yang, X., Wang, K., Qian, ZM, La3+-Induced Extracellular Signal-Regulated Kinase (ERK) Signaling via a Metal-Sensing Mechanism Linking Proliferation and Apoptosis in NIH 3T3 Cells, Biochemistry, 2006, 45, 11217-11225 (15) Zhang, Y., Yang, X., Wang, K., Crans, D.C., The Permeability and Cytotoxicity of Insulin-mimetic Vanadium (III, IV, V)-Dipicolinate Complexes, J. Inorg. Biochem, 2006, 100: 80-97 (16) Yu, S., Yuan, L., Yang, X., Wang, K., Qian, Z., La3+-Promoted Proliferation Could Be Interconnected with Apoptosis in NIH 3T3 Cells，J. Cell. Biochem. 2005，94，508-519 (17) Yang, X.-G., Yang, X., Yuan, L., Wang, K., Crans, D.C., The Permeability and Cytotoxicity of Insulin-mimetic Vanadium Compounds, Pharm. Res., 2004, 21/6, 1026-1033 (18) Liu, H., Yuan, L., Yang, X., Wang, K., La3+, Gd3+ and Yb3+ induced changes in mitochondrial structure, membrane permeability, cytochrome C release and intracellular ROS level. Chem-Biol. Inter., 2003,146, 27-37
