个人简历

2004年获北京大学医学博士，2004-2006无机化学博士后，曾在南加州大学药学院学习生物技术药物研发、哈佛医学院学习诱导多能干细胞的定向分化机制。硕士阶段（1997-2000）课题研究免疫细胞的肿瘤生物治疗，博士阶段（2001-2004）课题研究神经元的缺血损伤及保护途径，博后阶段（2004-2006）研究大分子脑内淋巴引流的途径，之后开展多项化学与医学密切交叉的科研课题。发表包括Science、Cell Stem Cell 、Sci Adv，Free Radic Biol Med、Biomaterial、J Neurochem、Neurotoxicology、Exp Cell Res、Cell Biol Toxicol、Chem Eur J、J Mater Chem 等国内外论文五十多篇论文，申请国际专利5项。2018年在研2项科技部重大新药创制项目、1项国家自然科学基金重大研究计划、重大1项国自然面上基金。参编国家“十三五”药理学双语教材，参与讲授《现代生物学技术》《化学生物学专业英文》等课程。目前担任中国微循环学会肿瘤专业委员会副主任委员，中国医促会临床微生物与感染分会常委，北京药学会药物化学生物学分会委员。

研究领域

1. 针对单基因遗传疾病，包括溶酶体病、肌营养不良与难治性癫痫种无义突变类型，研发致病蛋白促进通读药物，同时开发新型单碱基编辑系统，用于单基因遗传病的临床治疗。2. 制备新型工程细胞及类人器官制备：利用非天然糖分子，碱基，氨基酸制备新型生物药物工程细胞，用于蛋白药物的快速研发及生物治疗细胞的定向改造；应用前沿合成生物学和化学生物学技术改造基因密码子和蛋白翻译系统，制备新型干细胞组织器官，用于类器官组织重编程及功能重建；利用RNA基因编辑系统制备包装病毒的新型细胞系等。

近期论文

1. Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv. 2018, 11(4), in press. ( DOI: 10.1126/sciadv.aau8408) 2. Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q*, Zhou D*. Redirect Killer T Cells via Displaying Azido Sugar for Tethering Ligands. Chembiochem. 2017 Nov 2; 18(21):2082-2086. 3. Lu J, Zhang H, Chen X, Zou Y, Li J, Wang L, Wu M, Zang J, Yu Y, Zhuang W, Xia Q*, Wang J*. A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase. Free Radic Biol Med. 2017 Jul 12; 112: 287-297. 4. Lu J, Xia Q, and Zhou Q. How to make insulin-secreting pancreatic bcells for diabetes treatment. Sci China Life Sci, 2017 (3) :1-10. 5. Xu H, Wang Y, Lu J, Zhang B, Zhang Z, Si L, Wu L, Yao T, Zhang C, Zhang L, Xia Q*, Zhou D*. Re-exploration of the codon context effect on amber codon-guided incorporation of non-canonical amino acids in E. coli by the blue-white screening assay. Chembiochem. 2016 Jul 1;17(13):1250-1256. 6. Si L, Xu H, Zhou X, Zhang Z, Tian Z, Wang Y, Wu Y, Zhang B, Niu Z, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of Influenza A Viruses as Live but Replication-incompetent Virus Vaccines. Science, 2016 Dec 2;354(6316):1170-1173. 7. Ariyachet C, Tovaglieri, A, Xiang, G, Shah MS, Richmond CA, Lu J, Verbeke C, Brown J, Shivdasani R, Breault D, Mahony S, Xia Q, Mooney D, and Zhou Q*. Engineered stomach tissues as a renewable source of functional beta-cells for blood glucose regulation. Cell Stem Cell, 2016 Mar 3;18(3):410-421. 8. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ*. Cell Stem Cell. 2016 Jul 7;19(1):66-80. 9. Yang L, Song L, Liu X, Xia Q, Bai L, Gao G, Wang Y, Wei Z, Bai C, Li G. The Maternal Effect Genes UTX and JMJD3 Play Contrasting Roles in Mus musculus Preimplantation Embryo Development. Sci Rep.2016 Jul 7;6:26711. 10. Wu Y, Zhu H, Zhang B, Liu F, Chen J, Wang Y, Wang Y, Zhang Z, Wu L, Si L, Xu H, Yao T, Xiao S, Xia Q, Zhang L, Yang Z, Zhou D*. Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion. Bioconjugate Chem. 2016 Oct 19; 27(10):2460-2468. 11. Zhang B, Yang Q, Xu H, Wu Y, Wu L, Yao T, Zhang L, Xia Q*, Zhou D*. CRISPRi-Manipulation of Genetic Code Expansion via RF1 for Reassignment of Amber Codon in Bacteria. Sci Rep. 2016, Jan 28;6:20000. 12. Lu J, Cheng K, Zhang B, Xu H, Cao Y, Guo F, Feng X, Xia Q*. Novel mechanisms for superoxide-scavenging activity of human manganese superoxide dismutase determined by the K68 key acetylation site. Free Radic Biol Med. 2015 Aug; 85:114-26. 13. Cheng KY, Guo F, Lu JQ, Cao YZ, Xia Q*. MnTM-4-Pyp protects cortical neurons against oxidative stress via induction of cellular antioxidant response. Int J Dep Neurosci. 2015 Dec;47(Pt A):101.doi:10.1016/j.ijde vneu.2015.04.276. 14. Lu J, Cao Y, Cheng K, Xu B, Wang T, Yang Q, Yang Q, Feng X, Xia Q*. Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status. Exp Cell Res. 2015 Jun 10;334(2): 194-206. 15. Cheng KY, Guo F, Lu JQ, Cao YZ, Wang TC, Yang Q, Xia Q*. MnTM-4-PyP Modulates Endogenous Antioxidant Responses and Protects Primary Cortical Neurons against Oxidative Stress. CNS Neurosci Ther. 2015 May;21(5):435-45. 16. Zheng Y, Yu F, Wu Y, Si L, Xu H, Zhang C, Xia Q, Xiao S, Wang Q, He Q, Chen P, Wang J, Taira K, Zhang L, Zhou D*. Broadening the versatility of lentiviral vectors as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res.2015 Jun 23; 43(11): e73. 17. Xiong W, Zhao J, Yu H, Li X, Sun S, Li Y, Xia Q, Zhang C, He Q, Gao X, Zhang L, Zhou D*. Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stress.PLoS One. 2014 Nov 24; 9(11): e111911. 18. Zhang Y,Xia Q, Yang XD*, Wang K. Metallostasis and metal-based drugs for Alzheimer’s disease. Sci China Chem. 2014, 44(4): 541-554. 19. Huang HF, Guo F, Cao YZ, Shi W, Xia Q*. Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke.CNS Neurosci Ther. 2012, Oct; 18(10): 811-8.