个人简历

2004/9–2008/6武汉大学生命科学学院学习，获得理学学士学位；2008/9–2014/6中国科学院大学学习，获得生物化学与分子生物学专业理学博士学位。2014/7–2015/11在中国科学院生物物理研究所从事博士后研究，并于2015/12获评中国科学院生物物理研究所副研究员。2018年12月加入北京大学基础医学院免疫系，担任研究员职务、博士生导师。

研究领域

1．发现新的模式识别受体、鉴定新的特征性病原分子；2．探索天然免疫反应在造血干细胞发育分化过程中的调节作用、鉴定新的免疫细胞亚群

近期论文

Xia P,Wang S, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z. Circular RNA cia-cGAS protects dormant hematopoietic stem cells from cGAS-mediated exhaustion. Immunity 2018; 48: 688-701 e687.
Xia P,Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y, Fan Z. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat. Immunol. 2018; 19: 141-150.
Wang S#,Xia P#, Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z. Regulatory innate lymphoid cells control innate intestinal inflammation. Cell 2017; 171:201-216. (# co-first authors)
Xia P,Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y, Fan Z. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat. Immunol. 2016; 17: 369-378.
Xia P,Wang S, Ye B, Du Y, Huang G, Zhu P, Fan Z. Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection. Nat. Immunol. 2015; 16: 366-375.
Wang S#,Xia P#, Chen Y#, Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan Z. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity 2016; 45: 131-144. (# co-first authors)
Wang S#,Xia P#, Ye B, Huang G, Liu J, Fan Z. Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell stem cell 2013; 13: 617-625. (# co-first authors)
Xia P,Liu J, Wang S, Ye B, Du Y, Xiong Z, Han ZG, Tong L, Fan Z. WASH maintains NKp46+ ILC3 cells by promoting AHR expression. Nat. Commun. 2017; 8:15685.
Xia P,Wang S, Du Y, Huang G, Satoh T, Akira S, Fan Z. Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages. J. Exp. Med. 2015; 212: 2305-2321.
Xia P,Wang S, Xiong Z, Ye B, Huang LY, Han ZG, Fan Z. IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation. Nat. Commun. 2015; 6: 8132.
Xia P,Wang S, Huang G, Zhu P, Li M, Ye B, Du Y, Fan Z. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J. Exp. Med. 2014; 211: 2119-2134.
Xia P,Wang S, Huang G, Du Y, Zhu P, Li M, Fan Z. RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy. Cell Res. 2014; 24: 943-958.
Xia P,Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013; 32: 2685-2696.
Wang S#,Xia P#, Huang G, Zhu P, Liu J, Ye B, Du Y, Fan Z. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nat. Commun. 2016; 7: 11023. (# co-first authors)
Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z. The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling. Cell stem cell 2015; 16: 413-425.
Ye B, Liu B, Yang L, Huang G, Hao L, Xia P, Wang S, Du Y, Qin X, Zhu P, Wu J, Sakaguchi N, Zhang J, Fan Z. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 2017; 8(1):1518.
Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. J. Clin. Invest. 2015; 125: 3795-3808.
Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y, Fan Z. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J. Exp. Med. 2014; 211: 2439-2454.
Li M, Xia P, Du Y, Liu S, Huang G, Chen J, Zhang H, Hou N, Cheng X, Zhou L, Li P, Yang X, Fan Z. T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-gamma production of natural killer cells via beta-arrestin 2-mediated negative signaling. J. Biol. Chem. 2014; 289: 17647-17657.
Yang X, Xu M, Wang Y, Xia P, Wang S, Ye B, Tong L, Jiang T, Fan Z. Molecular mechanism for self-protection against the type VI secretion system in Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2014; 70(Pt 4):1094-103.
Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z. Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability. Stem Cells 2014; 32: 623-635.
Wang S, Xia P, Shi L, Fan Z. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. Cell Death Differ. 2012; 19: 605-615.
Huang L, Zhu P, Xia P, Fan Z. WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation. Cell Death Dis. 2016; 7:e2301