个人简历

教育经历: 1994 - 1999 , 理学博士 , 生物医学信息学 , 美国斯坦福大学医学院 1993 - 1994 , 理学硕士 , 应用数学 , 美国布朗大学 1989 - 1993 , 理学学士 , 无线电电子学系 , 中国科学技术大学 工作经历: 2004 - 至今 , 教授、主任 , 北京大学生命科学学院生物信息中心 2004 - 至今 , 副主任 , 蛋白质工程与植物基因工程国家重点实验室 2002 - 2004 , 客座助理教授 , 美国斯坦福大学医学院医学系 2001 - 2003 , 共同创始人及首席科学家 , 美国Nexus Genomics公司 2000 - 2001 , 研究员 , 美国Exelixis公司信息部

近期论文

1. Gao, G., Vibranovski, M.D., Zhang, L., Li, Z., Liu, M., Zhang, Y., Li, X.M., Zhang, W.X., Fan, Q., Long, M., Wei, L. , A long term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. , Genome Res , 2014 , 24: 629-638. 2. Tang H, et. al. , A large-scale screen for coding variants predisposing to psoriasis. , Nat Genet. , 2013 , Nov 10. doi: 10.1038/ng.2827 3. Huang Y, Xie C, Ye AY, Li CY, Gao G, Wei L. , Recent adaptive events in human brain revealed by meta-analysis of positively selected genes. , PLoS One. , 2013 , 2013 Apr 9;8(4):e61280. 4. Willsey AJ, et.al. , Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. , Cell. , 2013 , Nov 21;155(5):997-1007. doi: 10.1016/j.cell.2013.10.020. 5. Xie C, Zhang YE, Chen JY, Liu CJ, Zhou WZ, Li Y, Zhang M, Zhang R, Wei L, and Li CY. , Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs. , PLoS Genet. , 2012 , Sep;8(9):e1002942. (Co-corresponding author) 6. Zhang X, Bao X, Zhang J, Zhao Y, Cao G, Pan H, Zhang J, Wei L, Wu X. , Molecular characteristics of Chinese patients with Rett syndrome. , Eur J Med Genet. , 2012 , Dec;55(12):677-81. 7. Xu LM, Li JR, Huang Y, Zhao M, Tang X, Wei L. , AutismKB: an evidence-based knowledgebase of autism genetics. , Nucleic Acids Res. , 2011 , Epub2011 Dec 1. 8. Li CY, Zhou WZ, Zhang PW, Johnson C, Wei L, Uhl GR. , Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction. , BMC Genomics. , 2011 , Oct 15;12:508. 9. Li CY, Mao X, Wei L , Genes and (Common) Pathways Underlying Drug Addiction , Plos Computational Biology , 2008 , 4;4(1):e2 10. Ye ZQ, Zhao SQ, Gao G, Liu XQ, Langlois RE, Lu H, Wei L. , Finding new structural and sequence attributes to predict possible disease association of single amino acid polymorphism (SAP). , Bioinformatics. , 2007 , 23(12):1444-50. 11. Li CY, Yu Q, Ye ZQ, Sun Y, He Q, Li XM, Zhang W, Luo J, Gu X, Zheng X, Wei L. , A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. , Cell Res. , 2007 , 17(4):357-62. , [Abstract] , [Full Text], (Cover story) 12. Kong L, Zhang Y, Ye ZQ, Liu XQ, Zhao SQ, Wei L, Gao G , CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine , Nucleic Acids Res. , 2007 , 35:W345-9. 13. Zhang W, Zhang Y, Zheng H, Zhang C, Xiong W, Olyarchuk JG, Walker M, Xu W, Zhao M, Zhao S, Zhou Z, Wei L , SynDB: A Synapse protein DataBase based on Synapse Ontology , Nucleic Acids Res. , 2007 , 35:D737-41 14. Ye ZQ, Zhao SQ, Gao G, Liu XQ, Langlois RE, Lu H, Wei L. , Finding new structural and sequence attributes to predict possible disease association of single amino acid polymorphism (SAP). , Bioinformatics. , 2007 , 23(12):1444-50. 15. Li CY, Yu Q, Ye ZQ, Sun Y, He Q, Li XM, Zhang W, Luo J, Gu X, Zheng X, Wei L. , A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. , Cell Res. , 2007 , 17(4):357-62. , [Abstract] , [Full Text], (Cover story) 16. Kong L, Zhang Y, Ye ZQ, Liu XQ, Zhao SQ, Wei L, Gao G , CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine , Nucleic Acids Res. , 2007 , 35:W345-9. 17. Zhang W, Zhang Y, Zheng H, Zhang C, Xiong W, Olyarchuk JG, Walker M, Xu W, Zhao M, Zhao S, Zhou Z, Wei L , SynDB: A Synapse protein DataBase based on Synapse Ontology , Nucleic Acids Res. , 2007 , 35:D737-41 18. Zhang Y, Liu XS, Liu QR, Wei L. , Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species. , Nucleic Acids Res. , 2006 , 34(12):3465-75. 19. . Cai Z, Mao X, Li S, Wei L , Genome comparison using Gene Ontology (GO) with statistical testing, , BMC Bioinformatics , 2006 , 7:374.