个人简历

北京大学神经科学研究所，教授、北京大学麦戈文脑研究院PI，博士生导师，教育部长江学者奖励计划特聘教授、国家杰出青年基金获得者。现任基础医学院教学院长、神经科学研究所副所长。

研究领域

我们课题组主要从事神经系统细胞信号转导的研究。综合利用多学科手段，整合分子生物学、生物化学、遗传学、电生理学、形态学和行为学等方法

近期论文

1. Liu J, Du J, Wang Y. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2.Sci Signal.2019 Jun 11;12(585). pii: eaaw2040. doi: 10.1126/scisignal.aaw2040. PMID: 31186372
2. Hu F, Liu HC, Su DQ, Chen HJ, Chan SO, Wang YCA, Wang JCA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron.FASEB J. 2019 Jan;33(1):668-682. doi: 10.1096/fj.201800382RR. Epub 2018 Jul 19. PMID:30024789
3. Duo L, Hu L, Tian N, Cheng G, Wang H, Lin Z, Wang YCA, Yang YCA. TRPV1 gain-of-function mutation impairs pain and itch sensations in mice.Mol Pain. 2018 Jan-Dec;14:1744806918762031. doi: 10.1177/1744806918762031. Epub 2018 Feb 9.
4. Tian NX*, Xu Y*, Yang JY, Li L, Sun XH, Wang YCA and Zhang YCA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats.J Neurosci. 2018 Jan 15. pii: 2242-17. doi: 10.1523/JNEUROSCI.2242-17.2018. [Epub ahead of print] PMID: 29335353.
5. Cen C*, Luo LD*, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Zou YM, Wang YCA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus. J Neurosci.2018 Jan 3; 38(1):183-199.
6. Luo LD, Li G, Wang YCA. PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage. Scientific Reports. 2017 Jul 20; 7(1):6035. doi: 10.1038/s41598-017-06121-2.
7. Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang YCA, Zhang YCA.Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.Exp Neurol. 2017 Sep;295:66-76. doi: 10.1016/j.expneurol.2017.05.001. Epub 2017 May 4.
8. Qin R*, Cao S*, Lyu T, Qi C, Zhang W, Wang YCA.CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy.Cell Rep. 2017 Jan 10;18(2):380-390. doi: 10.1016/j.celrep.2016.12.043.
9. Zhang C*, Lu J*, Liu B, Cui QCA, Wang YCA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease.Aging (Albany NY). 2016 Feb;8(2):272-90.
10. Liu J*, Du J*, Yang Y, Wang YCA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia.Exp Neurol. 2015 Nov;273:253-62. doi: 10.1016/j.expneurol.2015.09.005. Epub 2015 Sep 12.
11. Wang Y. FXYD2: a promising drug target for inflammatory mechanical pain therapy. Science Bulletin2015, 60(9):896-898. (Research Highlight )
12. Wang GQ*, Cen C*, Cao S*, Li C*,Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA andWang YCA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun.2015, Jul 16; 6: 7660. doi: 10.1038/ncomms8660.
13. Zhang Y*, Wang N*, Su P, Lu J, Wang YCA. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice. Neurosci Bull. 2014, 30(6):1025-35.
14. Li Y*, Hu F*, Chen HJ*, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang YCA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal. 2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353.
15. Wang N*, Su P*, Zhang Y*, Lu J*, Xing BM, Kang K, Li WQ, Wang YCA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol. 2014, 39(5):1290-301.
16. Qi C*, Liu SM*, Qin R*, Zhang Y, Wang GQ, Shang, YF, Wang YCA and Liang JCA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. J Neurosci. 2014 March 26;34(13):4494-508.
17. Li G, Wang YCA. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system. Neurosci Bull. 2014 Jun;30(3):497-504. doi: 10.1007/s12264-013-1403-2. Epub 2014 Feb 13.
18. Xing BM*, Yang YR*, Du JX*, Chen HJ, Qi C, Huang ZH, Zhang YCA and Wang YCA. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci. 2012 Oct 17;32(42):14709-21.
19. Zhu YB*, Kang K*, Zhang Y, Qi C, Li G, Yin DMCA and Wang YCA. PLD1 negatively regulates dendritic branching.J Neurosci.2012 Jun 6;32 (23):7960-9.
20. Wang KWCA,Wang YCA. Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection? Front Mol Neurosci. (Invited review) 2012 Mar 15;5:39.