个人简历

受教育经历
1959年，毕业于北京医学院医疗系本科；
1964年，毕业于北京医学院生物化学专业研究生；
1978.12-1981.5，教育部派出改革开放后我国首批访美学者，美国约翰．霍普金斯大学访问学者,美国国立卫生研究院(NIH)博士后训练。
工作经历
1964.3 北京医学院生化教研室助教;
1978.12 北医生化教研室讲师(82 起任教研室副主任);
1985.12 北医生化教研室副教授,副主任(1986-88美国加州大学等研究访问);
1988.9 北医生化系教授,副主任(1995-98北大生命科学院兼职教授);
2000.4- 北大医学部生化系教授，衰老分子机理研究室主任。
2005- 中国科学院院士

近期论文

1 Zhang XW, Chen Z, Chen YL, Tong TJ. Delivering antisense telomerase RNA by a hybrid adenovirus/adeno-associated virus significantly suppresses malignant phenotypes and enhances cell apoptosis of human breast cancer cells. Oncogene 2003, 22 (16): 2405-2416. (03年影响因子 6.495）
2 Mao ZB, Shan S, Zhu YY, Yi X, Zhang H, Shang YF, Tong TJ. Transcriptional regulation of A33 antigen expression by gut-enriched kruppel-like factor. Oncogene 2003, 22 (28): 4434-4443. (03年影响因子 6.495）
3 Wang PC, Zhang ZY, Ma XF, Huang Y, Liu XW, Tu PF, Tong TJ. HDTIC-1 and HDTIC-2, two compounds extracted from Astragali Radix, delay replicative senescence of human diploid fibroblasts Mech Age Dev 2003,124(10-12): 1025-1034 (03年影响因子 3.214）
4 Huang Y, Corbley MJ, Tang ZQ, Yang L, Peng Y, Zhang ZY, Tong TJ, Down-regulation of p21WAF1 promotes apoptosis in senescent human fibroblasts: involvement of retinoblastoma protein phosphorylation and delay of cellular aging. J Cell Physiol 2004, 201(3): 483-491.（04年影响因子5.222）
5 Duan JM, Chen Z, Liu PH, Zhang ZY, Tong ZY. Wild type p16ink4a suppresses cell growth and telomerase activity in human breast cancer mcf-7 cells. Int J Oncology 2004 24(6): 1597-1605. (04年影响因子 3.056）
6 Xue LX, Zheng WJ, Wu JF, Wang PC, Li J, Zhang ZY, Tong TJ. Sp1 is involved in the transcriptional activation of p16ink4 by p21waf1 in hela cells. FEBS Lett 2004, 564(1-2) : 199-204 (04年影响因子 3.843）
7 Zheng WJ, Wang HY, Xue LX, Zhang ZY, Tong TJ. Regulation of cellular senescence and p16 INK4A expression by Id1 and E47 proteins in human diploid fibroblast. J Biol Chem 2004,279(30):31524-31532. (04年影响因子 6.355)
8 Ma H , Li RZ, Zhang ZY, Tong TJ. mRNA level of alpha-2-macroglobulin as an aging biomarker of human fibroblasts in culture. Exp Gerontol 2004,39(3): 415-421. (04年影响因子 2.880）
9 Guo SZ, Zhang ZY, Tong TJ. Cloning and characterization of cellular senescence-associated genes in human fibroblast cell by suppression subtractive hybridization,Exp Cell Res 2004，298（2）465-472 (04年影响因子 4.007)
10 Zhu WG, Hileman T, Ke Y, Wang PC, Lu SL, Duan WR, Dai ZY, Tong TJ, Villalona-Calero MA, Plass C, Otterson GA. 5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferatione. J Biol Chem 2004,279 (15): 15161-15166 . (04年影响因子6.355）
11 Zhao L, Tong T, Zhang Z. Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts.FASEB J. 2005 Apr;19(6):521-32. (04年影响因子6.82）
12 Duan J, Duan J, Zhang Z, Tong T. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int J Biochem Cell Biol. 2005 Jul;37(7):1407-20. (04年影响因子3.578）