研究领域

从基因转录调控和蛋白质翻译后修饰两方面探究肿瘤发生发展及代谢性疾病的发病机制，鉴定参与其中的表观遗传修饰酶、蛋白激酶、泛素连接酶及去泛素化酶，通过对酶生物学功能的解析，为精准医学提供潜在的药物靶点。

近期论文

1. Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan,Chengjian Guan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Rong Liu, Luyang Sun# and Yongfeng Shang# (2018). Imbalance of the reciprocally inhibitory loop between theubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Research28(9):934-951. (IF: 15.4)
2. Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun# (2017). JMJD6 Promotes Melanoma Carcinogenesis through Regulation of the Alternative Splicing of PAK1, a Key MAPK Signaling Component.Molecular Cancer 2017 16:175. (IF: 6.2)
3. Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, andLuyang Sun# (2017). ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nature Communication 8(1):691. (IF:12.13)
4. Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun#, and Yongfeng Shang#(2015). SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes &Development29(6):672-85. (IF: 12.64)
5. Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun#, and Yongfeng Shang#(2014). JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. PLOS Biology12(3):e1001819. (IF:12.69)
6. Na Yu, Peiwei Huangyang, Xiaohan Yang, Xiao Han, Ruorong Yan, Hongti Jia, Yongfeng Shang, and Luyang Sun# (2013).MicroRNA-7 Suppresses EMT and Invasion of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Lysine Methyltransferase SET8. Journal of Biological Chemistry288(27): 19633-42.(IF:4.6)
7. Lei Shi*,Luyang Sun*, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, Yongfeng Shang (2011). JMJD2B Coordinates H3K4/H3K9 Methylation and Promotes Hormonally Responsive Breast Carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America108(18):7541-6.(IF: 9.770)
8. Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao, and Yongfeng Shang (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization.Journal of Biological Chemistry286(6):4226-35. (IF:5.314)
9. Luyang Sun*, Lei Shi*, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang (2009). JFK, a Kelch Domain-containing F-box Protein, Links the SCF Complex to p53 Regulation.Proceedings of the National Academy of Sciences of the United States of America106(25): 10195-10200. (IF: 9.770)