个人简历

教育背景: 2011-至今 北京大学合成与功能生物分子中心 Co-PI 2006-至今 北京大学化学系 副研究员 2004-2006 中科院微生物所 博士后 1999-2004 军事医学科学院 遗传学 博士 1994-1998 北京大学 生命科学学院 学士 工作简历介绍 目前系北京大学化学与分子工程学院化学生物学系以及北京大学合成与功能生物分子中心副研究员，博士生导师。同时是何川教授（美国芝加哥大学课题网址：he-group.uchicago.edu）的Co-PI。并且，在任职期间曾获批国家自然基金面上以及多个国家科技部973项目、重大新药创制项目，国家自然基金委优秀青年基金、绿叶生物医药杰出青年学者奖。近5年内，发表论文数十篇,其中有5篇在Autophagy, Advanced Materials, ACS Nano等国际一流杂志上发表，总引用次数超过1600次。

研究领域

基于Homics平台的疾病治疗诊断预判及新药研发 Homics平台主要整合5hMc表观遗传测序精准诊断技术、circRNA、lncRNA、miRNA、mRNA等检测技术，对病人样本进行分析检测，最终将区分出有效人群与无效人群，再根据无效人群的耐药标志物，做出“新”的治疗药物，提高病人治疗有效率。 基于短肽及蛋白偶联或包裹的新药研发 短肽及蛋白偶联的药物研发平台主要以噬菌体展示库、酵母表面展示为基础、经过高通量筛选技术及化学合成手段，制备出优质性较强的纳米抗体、功能性多肽、功能蛋白及其他生物大分子；结合当前治疗癌症的困惑性问题，努力做出新型纳米抗体药物、多肽偶联药物及蛋白质偶联药物。

近期论文

X. Zhu, R. Li, L. Xu, H. Yin, L. Chen, Y. Yuan, W. Zhong, J. Lin *. A Novel Self-Assembled Mitochondria-Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer. Small. 2018,1803428. D. Hong, X. Zhang, R. Li, Y. Lou, Q. He, X. Li, D. Xu, P. Lv, J. Lin *. Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway. Cell Death Differ. 2018. L. Zhang, H. Niu, W. Zhong, J. Lin *, Y. Zhang *. Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20. Scientific Reports. 2015, 5: 12003. W. Zhong, H. Zhu, F. Sheng, Y. Tian, J. Zhou, Y. Chen, S. Li *, J. Lin *. Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Autophagy. 2014, 10, 7, 1285-1300. T. Wang, H. Zhu, J. Zhuo, Z. Zhu, Pagona P, Gennady L, J. Lin *, M. Li *. Biosensor Based on Ultrasmall MoS Nanoparticles for Electrochemical Detection of HO Released by Cells at the Nanomolar Level. Analytical chemistry. 2013, 85, 21, 10289-10295. C. Zhou, W. Zhong, J. Zhou, F. Sheng, Z. Fang, Y. Wei, Y. Chen, X. Deng*, B. Xia, J. Lin *. Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells. Autophagy. 2012, 8, 8, 1215-1226. S. Tian*, J. Lin *, Z.-J. Jun, X. Wang, Y. Li, X. Ren, W. Yu, W. Zhong, J. Xiao, F. Sheng, et al. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy. 2010, 6, 8, 1032-1041. X. Ren, J. Lin *, C. Jin, B. Xia*. Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain. FEBS letters. 2010, 584, 19, 4222-4226. J. Lin *, Z. Zheng *, Y. Li, W. Yu, W. Zhong, S. Tian, F. Zhao, X. Ren, J. Xiao, N.Wang, et al. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy. 2009, 5, 3, 314-320. J. Lin *, R. Jin*, B. Zhang*, H. Chen, Y.-X. Bai, P.-X. Yang, S.-W. Han, Y.-H. Xie, P.-T. Huang, C. Huang, et al. Nucleolar localization of TERT is unrelated to telomerase function in human cells. Journal of cell science. 2008, 121, 13, 2169-2176.