林一瀚
近期热点
资料介绍
个人简历
2011年毕业于芝加哥大学获博士学位; 2005年毕业于中国科学技术大学获学士 学位;研究兴趣:本实验室聚焦干细胞、免疫细胞、及肿瘤细胞的异质性和细胞命运决策机制。通过发展新型的定量单细胞实验与分析技术,并结合系统生物学方法与合成生物学手段,在单细胞水平上研究细胞异质性及命运决策的关键调控要素,以期在单细胞水平上深入理解发育、免疫、疾病等重要过程,并进一步利用药物或合成生物器件对这些过程进行精准干预。近期具体研究方向包括:新型单细胞工具的开发(single-cell techniques);基因转录调控的噪音与动力学(noise and dynamics);转录调控中的相分离现象(phase separation);表观调控机制(epigenetic regulation);基因网络中的反馈回路(feedback loops);干细胞稳态维持及分化(homeostasis and differentiation)。 工作经历:2017年1月至今,北京大学定量生物学中心 研究员2011年9月-2016年12月,加州理工学院 生命科学与工程部 博士后 获奖情况:Finalist, BWF Career Awards at the Scientific Interface (2015).The Elizabeth R. Norton Prize for Excellence in Research in Chemistry, University of Chicago (2011).Marine Biological Laboratory Scholarship, Anita Zorzoli Memorial Fund (2010).Zhang Zong-Zhi Fellowship, Zhang Zong-Zhi Fund (2005).Excellent Thesis Award in Undergraduate Research, University of Science and Technology of China (2005).研究领域
研究方向:定量单细胞生物学、系统生物学、合成生物学近期论文
代表性文章:At PKU:1. Jianhan Zhang#, Xu Han#, Yihan Lin*, Dissecting the regulation and function of ATP at the single-cell level, PLOS Biology 2018, 16(12): e3000095 (*corresponding author)2. Rosa Martinez-Corral, Elba Raimundez, Yihan Lin, Michael B. Elowitz, Jordi Garcia-Ojalvo*, Self-amplifying pulsatile protein dynamics without positive feedback, Cell Systems 2018, 7(4): 453-4623. Jin Park, Marta Dies, Yihan Lin, Sahand Hormoz, …, Michael B. Elowitz*, Molecular time sharing through dynamic pulsing in single cells, Cell Systems 2018, 6(2): 216-2294. Jiegen Wu, Xu Han, Haotian Zhai, Tingyu Yang, Yihan Lin*. Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells. Molecular Systems Biology 2020, 16, e9335 (*corresponding author).Prior to PKU: 5. Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai & Michael B. Elowitz*. Combinatorial gene regulation by modulation of relative pulse timing, Nature 2015, 527(7576):54-586. Joseph H. Levine#, Yihan Lin#, & Michael B. Elowitz*. Functional roles of pulsing in genetic circuits. Science, 342(6163): 1193-1200, 2013 (# co-first author)7. Yihan Lin and Michael B. Elowitz*, Central dogma goes digital, Molecular Cell, 61: 791-792, 2016.8. Yihan Lin, Ying Li, Sean Crosson, Aaron R. Dinner* & Norbert F. Scherer*, Phase resetting reveals network dynamics underlying a bacterial cell cycle, PLOS Computational Biology, 8(11): e1002778, 2012.9. Yihan Lin, Sean Crosson* & Norbert F. Scherer*, Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion, Molecular Systems Biology, 6: 445, 2010.担任职务:北京大学前沿交叉学科研究院研究员北京大学定量生物学中心研究员北京大学-清华大学生命科学联合中心研究员 相关热点