个人简历

教育经历 1997/9 – 2001/6 ，美国加州大学洛杉矶分校，统计系，统计学专业，博士学位(导师：Wing Wong) 1991/9 – 1995/6 ，北京师范大学，数学系，计算机专业，学士学位 工作经历 1.2013.4 – 今， 北京大学生命科学学院、北大-清华生命科学联合中心、统计科学中心，高级研究员 2.2002/7 – 2013/3，Dana-Farber癌症研究所，助理教授、副教授 3.2008/7 – 2013/3，美国哈佛大学公共卫生学院，生物统计系，副教授 4.2002/7 – 2008/6，美国哈佛大学公共卫生学院，生物统计系，助理教授 5.2001/7 – 2002/6，美国哈佛大学公共卫生学院，生物统计系，博士后（导师：Wing Wong）

研究领域

实验室主要研究兴趣为：癌症基因组学高通量测序数据的产生、建模、实验验证，目的是寻找个体化癌症医疗中新的致病和治疗机制，以及预测个体化用药效果的统计建模。代表研究项目包括底层数据分析，如使用高通量测序技术，精确地找出癌症样本中的发生的各种变异；整合性数据分析，如拷贝数、基因表达、小RNA 等癌症变异之间的调控关系、它们怎样帮助理解病理和预测治疗效果。

近期论文

1.Wang Y, Fan C, Zheng Y, Li C*. Dynamic chromatin accessibility modeled by Markov process of randomly-moving molecules in the 3D genome. Nucleic Acids Res. 2017 Feb 9. doi: 10.1093/nar/gkx086. 2.Li R#, Liu Y#, Li T, Li C*. 3Disease Browser: A Web server for integrating 3D genome and disease-associated chromosome rearrangement data. Sci Rep. 2016 Oct 13;6:34651. 3.Wang X, Yan Z, Fulciniti M, Li Y, Gkotzamanidou M, Amin SB, Shah PK, Zhang Y, Munshi NC*, Li C*. Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma. Leukemia. 2014, 28(4):894-903 4.Samur MK#, Shah PK#, Wang X, Minvielle S, Magrangeas F, Avet-Loiseau H, Munshi NC*, Li C*. The shaping and functional consequences of the dosage effect landscape in multiple myeloma. BMC Genomics. 2013,2;14:672. 5.Li Y#, Wang X#, Zheng H, Wang C, Minvielle S, Magrangeas F, Avet-Loiseau H, Shah PK, Zhang Y, Munshi NC, Li C*. Classify hyperdiploidy status of multiple myeloma patients using gene expression profiles. PLoS One. 2013;8(3):e58809. PubMed PMID: 23554930. 6.Samur MK#, Yan Z, Wang X, Cao Q, Munshi NC, Li C*, Shah PK*,#. canEvolve: a web portal for integrative oncogenomics. PLoS One. 2013;8(2):e56228. PubMed PMID: 23418540. 7.Yan Z, Shah PK, Amin SB, Samur MK, Huang N, Wang X, Misra V, Ji H, Gabuzda D, Li C*. Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res. 2012,1;40(17):e135 8.Huang N#, Shah PK*,#, Li C*. Lessons from a decade of integrating cancer copy number alterations with gene expression profiles. Brief Bioinform. 2012 May;13(3):305-16. 9.Liu M, Li Y, Liu A, Li R, Su Y, Du J, Li C, Zhu AJ. The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. Elife. 2016 Aug 18;5. pii: e17200. 10.Amin SB, Yip WK, Minvielle S, Broyl A, Li Y, Hanlon B, Swanson D, Shah PK, Moreau P, van der Holt B, van Duin M, Magrangeas F, Pieter Sonneveld P, Anderson KC, Li C, Avet-Loiseau H, Munshi NC. Gene expression profile alone is inadequate in predicting complete response in multiple myeloma. Leukemia. 2014 Nov;28(11):2229-34. 11.Jin Y, Li F, Zheng C, Wang Y, Fang Z, Guo C, Wang X, Liu H, Deng L, Li C, Wang H, Chen H, Feng Y, Ji H. NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition. Int J Cancer. 2014 May 15;134(10):2294-304. 12.Ouillette P, Saiya-Cork K, Seymour E, Li C, Shedden K, Malek SN. Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia. Clin Cancer Res. 2013 Jun 1;19(11):2893-904. 13.Bae J, Munshi A, Li C, Samur M, Prabhala R, Mitsiades C, Anderson KC, Munshi NC. Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells. J Immunol. 2013 Feb 1;190(3):1360-71. 14.Parkin B, Ouillette P, Li Y, Keller J, Lam C, Roulston D, Li C, Shedden K, Malek SN. Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia. Blood. 2013 Jan 10;121(2):369-77. 15.Wang C, Tian R, Zhao Q, Xu H, Meyer CA, Li C, Zhang Y, Liu XS. Computational inference of mRNA stability from histone modification and transcriptome profiles. Nucleic Acids Res. 2012 Aug;40(14):6414-23.