个人简历
教育经历: 2001 - 2006 , 理学博士 , 生物化学与分子生物学 , 北京大学 1997 - 2001 , 理学学士 , 生物化学与分子生物学 , 北京大学 2009 Mayo Clinic“Kendall-Mayo 奖学金” 工作经历: 2012－至今 研究员 北京大学生命科学学院 2012－至今 研究员 北大清华生命科学联合中心 2006－2011 博士后 美国梅奥医学院癌症中心（Mayo Clinic Cancer Center）
研究领域
后基因组时代生命科学领域的一个关键问题是多细胞生物如何将同一个基因组展示成众多形态与功能迥异的不同类型细胞的转录组，例如人体中高度分工的数百种细胞。表观遗传学正是为了回答这一关键科学问题而兴起的新兴学科。表观遗传的核心是染色质层面的调控，在生殖发育、细胞编程与重编程、衰老与疾病发生等过程中发挥关键作用。研究表明几乎所有的表观遗传事件都与染色质息息相关，因为染色质是DNA所编码的基因信息的解调器。
近期论文
1.Shuqi Li#, Zhiyun Xu#, Jiawei Xu#, Linyu Zuo, Chuanhe Yu, Pu Zheng, Haiyun Gan, Xuezheng Wang, Longtu Li, Sushma Sharma, Andrei Chabes, Xuezheng Wang, Di Li, Sheng Wang, Sihao Zheng, Jinbao Li, Xuefeng Chen, Yujie Sun, Dongyi Xu, Junhong Han, Kuiming Chan, Zhi Qi,Jianxun Feng* and Qing Li*. Rtt105 functions as a chaperone for Replication Protein A to preserve genome stability. The EMBO Journal, 2018 (Accepted) 2. Xiaowei Yan＃, Jiayi Yang＃, Jiawei Xu＃, Jianxun Feng*, and Qing Li*, Histone chaperone Spt16p is required for heterochromatin mediated silencing in budding yeast, Protein & Cell, 2017, doi:10.1007/s13238-017-0485-4 3.. Shaofeng Liu＃, Zhiyun Xu＃, He Leng＃, Pu Zheng, Jiayi Yang, Kaifu Chen, Jianxun Feng, Qing Li*, RPA binds histone H3-H4 and functions in DNA replication–coupled nucleosome assembly, Science, 2017,355:415-420. 4. Jianxun Feng＃, Haiyun Gan＃, Matthew L. Eaton, Hui Zhou, Shuqi Li, Jason A. Belsky, David M. MacAlpine, Zhiguo Zhang* and Qing Li*, Non-coding transcription is a driving force for nucleosome instability in spt16 mutant cells, Molecular and Cellular Biology, 2016, 36:1856-1867. 5. Jiayi Yang＃, Xu Zhang＃, Jianxun Feng＃, He Leng, Shuqi Li, Junyu Xiao, Shaofeng Liu, Zhiyun Xu, Jiawei Xu, Di Li, Zhongshi Wang, Jingyang Wang, Qing Li*，The histone chaperone FACT contributes to DNA replication-coupled nucleosome assembly，Cell Reports，2016，14:1128-1141. 6. Dan Su#, Qi Hu#, Qing Li#, James R. Thompson, Gaofeng Cui, Ahmed Fazly, Brian A. Davies, Maria Victoria Botuyan, Zhiguo Zhang* & Georges Mer*. Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106 , Nature , 2012 ,483:104-7. 7. Qing Li, Ahmed Fazly, Hui Zhou, Shengbing Huang, Zhiguo Zhang* and Bruce Stillman*. The Elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genetics 2009, 5 (10): e1000684. 8. Qing Li＃, Hui Zhou＃, Hugo Wurtele, Brian Davies, Bruce Horazdovasky, Alain Verreault* and Zhiguo Zhang*. Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell 2008, 134: 244-255.
