个人简历

李川昀，2009年获北京大学理学博士学位，曾在美国NIH从事复杂疾病研究，2011年在北京大学建立实验室，任研究室主任，博士生导师；2019年通过北京大学终身评估。国家“优秀青年科学基金”获得者。研究主要运用恒河猴作为人类近缘模式动物的优势，开展人类演化与代谢疾病分子机制研究。近年来将前沿的生物信息学方法、分子演化理论和功能基因组学策略引入非人灵长类研究领域，在探究人类特异基因与调控的起源规律，揭示重大代谢疾病新靶点等方面研究中取得突出成果。发表SCI论文36篇，其中作为通讯或共同通讯作者，在PNAS、Circulation Research、Genome Biology、Nature Communications等学术期刊发表论文13篇。曾获“贝时璋青年生物物理学家奖”等奖项，指导的博士生获“吴瑞奖”、入选国家“博新计划”等。多次受邀进行学术报告，担任中国动物学会灵长类学分会理事、中国实验动物学会灵长类专业委员会常务委员、中国生命电子学会委员等学术兼职。

研究领域

近年来将前沿的生物信息学方法、分子演化理论和功能基因组学策略引入非人灵长类研究领域

近期论文

1. Yumei Li*, Shanshan Ai*, Xianhong Yu*, Chen Li, Xin Li, Yanzhu Yue, Cheng Li, Chuan-Yun Li# and Aibin He#. Replication-independent histone turnover underlines the epigenetic homeostasis in adult heart, Circulation Research, 2019
2. Ni A. An*, Wanqiu Ding*, Xin-Zhuang Yang*, Jiguang Peng, Bin Z. He, Qing Sunny Shen, Fujian Lu, Aibin He, Yong E. Zhang, Bertrand Chin-Ming Tan, Jia-Yu Chen# and Chuan-Yun Li#, Evolutionarily Significant A-to-I RNA Editing Events Originated through G-to-A Mutations in Primates, Genome Biology, 2019
3. Yumei Li*, Chen Li*, Shuxian Li, Qi Peng, Ni A. An, Aibin He# and Chuan-Yun Li#, Human Exonization through Differential Nucleosome Occupancy, PNAS, 2018
4. Yao Xiao, Can Wang, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen, Ju Chen, Rui-Ping Xiao, Chuan-Yun Li# and Xiuqin Zhang#, Deficiency of PRKD2 Triggers Hyperinsulinemia and Metabolic Disorders, Nature Communications, 2018
5. Shi-Jian Zhang*, Chenqu Wang*, Shouyu Yan, Aisi Fu, Xuke Luan, Yumei Li, Qing Sunny Shen, Xiaoming Zhong, Jia-Yu Chen, Xiangfeng Wang, Bertrand Chin-Ming Tan, Aibin He and Chuan-Yun Li#, Isoform Evolution in Primates Through Independent Combination of Alternative RNA Processing Events, Molecular Biology and Evolution, 2017 (Cover Story, Fast Track Story)
6. Lei Lei*, Shou-Yu Yan*, Ran Yang, Jia-Yu Chen, Yumei Li, Ye Bu, Nannan Chang, Qinchao Zhou, Xiaojun Zhu, Chuan-Yun Li#, Jing-Wei Xiong#, Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors, Nucleic Acids Research, 2016
7. Xiaoming Zhong*, Jiguang Peng*, Qing Sunny Shen*, Jia-Yu Chen, Han Gao, Xuke Luan, Shouyu Yan, Xin Huang, Shi-Jian Zhang, Luying Xu, Xiuqin Zhang, Bertrand Tan and Chuan-Yun Li#, RhesusBase PopGateway: Genome-wide Population Genetics Atlas in Rhesus Macaque, Molecular Biology and Evolution, 2016 (Featured by MBE)
8. Xin-Zhuang Yang*, Jia-Yu Chen*, Chu-Jun Liu, Jiguang Peng, Yin Rei Wee, Xiaorui Han, Chenqu Wang, Xiaoming Zhong, Qing Sunny Shen, Hsuan Liu, Huiqing Cao, Xiaowei Chen, Bertrand Chin-Ming Tan# and Chuan-Yun Li#, Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Molecular Biology and Evolution, 2015
9. Jia-Yu Chen*, Qing Sunny Shen*, Wei-Zhen Zhou*, Jiguang Peng, Bin Z He, Yumei Li, Chu-Jun Liu, Xuke Luan, Wanqiu Ding, Shuxian Li, Chunyan Chen, Bertrand Chin-Ming Tan, Yong E Zhang, Aibin He# and Chuan-Yun Li#, Emergence, Retention and Selection: a Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates, PLoS Genetics, 2015
10. Shi-Jian Zhang*, Chu-Jun Liu*, Peng Yu*, Xiaoming Zhong, Jia-Yu Chen, Xin-Zhuang Yang, Jiguang Peng, Shouyu Yan, Chenqu Wang, Xiaotong Zhu, Jingwei Xiong, Yong E. Zhang, Bertrand Chin-Ming Tan and Chuan-Yun Li#, Evolutionary Interrogation of Human Biology in Well-annotated Genomic Framework of Rhesus Macaque, Molecular Biology and Evolution, 2014 (Cover Story, MBE Most Read)
11. Jia-Yu Chen*, Zhiyu Peng*, Rongli Zhang*, Xin-Zhuang Yang, Bertrand Chin-Ming Tan, Huaying Fang, Chu-Jun Liu, Yong E. Zhang, Mingming Shi, Zhi-Qiang Ye, Minghua Deng, Xiuqin Zhang# and Chuan-Yun Li#, RNA Editome in Rhesus Macaque Shaped by Purifying Selection, PLoS Genetics, 2014
12. Shi-Jian Zhang*, Chu-Jun Liu*, M Shi*, Lei Kong, Jia-Yu Chen, Wei-Zhen Zhou, Xiaotong Zhu, Peng Yu, Jue Wang, Xinzhuan Yang, Ning Hou, Zhiqiang Ye, Rongli Zhang, Ruiping Xiao, Xiuqin Zhang# and Chuan-Yun Li#, RhesusBase: a Knowledgebase for the Monkey Research Community. Nucleic Acids Research, 2013 (Featured by Nucleic Acids Research and Biomart)
13. Chen Xie*, Yong E. Zhang*, Jia-Yu Chen*, Chu-Jun Liu, Wei-Zhen Zhou, Ying Li, Mao Zhang, Rongli Zhang, Liping Wei# and Chuan-Yun Li#, Hominoid-specific De Novo Protein-coding Genes Originating from Long Non-coding RNAs, PLoS Genetics, 2012 (Featured by Faculty of 1000)
14. Chuan-Yun Li#, Wei-Zhen Zhou, Ping-Wu Zhang, Catherine Johnson, Liping Wei, George R Uhl#, Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction, BMC Genomics, 2011 (Highly accessed article)
15. Chuan-Yun Li, Yong Zhang, Zhanbo Wang, Yan Zhang, Chunmei Cao, Xiao-Mo Li, Ping-Wu Zhang, Shu-Juan Lu, Quan Yu, Xiaofeng Zheng, Quan Du, Qing-Rong Liu* and Liping Wei*, A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions, PLoS Computational Biology, 2010
16. Chuan-Yun Li, Xizeng Mao & Liping Wei, Genes and (Common) Pathways Underlying Drug Addiction, PLoS Computational Biology, 2008 (Featured by Science Signaling “Editor’s Choice”; Nature China “Research Highlights”; the Economist, Scientific America, Reuters and China Daily; Top 10 Papers downloaded from PLoS Computational Biology)
17. Chuan-Yun Li, Qingrong Liu, Ping-Wu Zhang, Xiao-Mo Li, Liping Wei, George R Uhl, OKCAM: An Ontology-based, Human-centered Knowledgebase for Cell Adhesion Molecules, Nucleic Acids Research, 2008
18. Chuan-Yun Li*, Zhi-Qiang Ye*, Quan Yu*, Ying Sun, Quanyuan He, Xiao-Mo Li, Wuxue Zhang, Jingchu Luo, Xiaocheng Gu, Xiaofeng Zheng & Liping Wei, A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir, Cell Research, 2007 (Cover story and featured by a Research Highlight; Cited by US FDA annual Pediatric Safety Update for Tamiflu; Interviewed by NHK and CCTV)