个人简历

韩文玲，女，1970年9月出生，山东龙口人。现任北京大学免疫学系教授，博士生导师，免疫学系副主任，北京大学人类疾病基因研究中心副主任。1998年，韩文玲利用SSH技术开始人类新细胞因子和免疫细胞膜分子研究。在国际上，首次报道了一个新基因家族CMTM。在人类，该家族包括9个成员，即CKLF和CMTM1-8，在免疫系统、男性生殖系统发挥重要作用，并参与肿瘤的发生、发展。国内、外研究发现CMTM家族多个成员定位于网格蛋白包被的囊泡和内体中，调控EGFR、BCR、PD-L1等膜分子的转运、稳定性和信号转导，是潜在的肿瘤治疗靶点。2008年，韩文玲与国家人类基因组北方研究中心合作，利用免疫组学技术发现潜在新细胞因子和免疫细胞膜分子，进行功能、机制和疾病相关性研究，发现多个具有重要免疫调控功能的新分子。作为第一作者或责任作者发表SCI论文36篇，包括Cancer Res、Oncogene、J Immunol、Oncoimmunology等；申请发明专利12项。独立培养博士生16名，多名学生获得北京市优秀毕业生和北京大学优秀博士论文等荣誉。
1989年9月-1994年7月，泰山医学院医疗系，获医学学士学位；
1994年9月-1999年7月，北京医科大学，导师马大龙教授，获医学博士学位；
1999年8月-2001年7月，北京大学医学部，讲师；
2001年8月-2006年7月，北京大学医学部，副教授；
2006年8月-至今，北京大学医学部，教授

研究领域

新细胞因子和免疫细胞膜分子的功能、机制和应用研究

近期论文

1. Han W#, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, Gu W, Huang J, Gui L, Tang Y, Li F, Song Q, Di C, Wang L, Shi Q, Sun R, Xia D, Rui M, Tang J, Ma D*. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity.Biochem J. 2001 Jul 1; 357(Pt 1):127-35.
2. Han W#, Ding P#, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D*. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.Genomics. 2003 Jun; 81(6):609-17.
3. Li T, Han W*, Yang T, Ding P, Rui M, Liu D, Wang Y, Ma D. Molecular cloning and identification of mouse Cklfsf2a and Cklfsf2b, two homologues of human CKLFSF2.Int J Biochem Cell Biol. 2006 Mar; 38(3):420-9.
4. Li T, Zhong J, Chen Y, Qiu X, Zhang T, Ma D, Han W*. Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation.Life Sci. 2006 Jul 4; 9(6):519-24.
5. Zhong J, Wang Y, Qiu X, Mo X, Liu Y, Li T, Song Q, Ma D, Han W*. Characterization and expression profile of CMTM3/CKLFSF3.J Biochem Mol Biol. 2006 Sep 30; 39(5):537-45.
6. Wang Y, Li T, Qiu X, Mo X, Zhang Y, Song Q, Ma D, Han W*. CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells. Biochem Biophys Res Commun.2008, Jun 20; 371 (1): 54-8
7. Yu C#,Han W#,Shi T, Lv B, He Q, Zhang Y, Li T, Zhang Y, Song Q, Wang L, Ma D*. PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway. Cell Signal. 2008 Dec; 20(12):2208-20.
8. Shao L, Guo X, Plate M, Li T, Wang Y, Ma D, Han W*. CMTM5-v1 induces apoptosis in cervical carcinoma cells.Biochem Biophys Res Commun. 2009 Feb 20; 379 (4):866-71.
9. Wang Y, Li J, Cui Y, Li T, Ng KM, Geng H, Li H, Shu XS, Li H, Liu W, Luo B, Zhang Q, Mok TS, Zheng W, Qiu X, Srivastava G, Yu J, Sung JJ, Chan AT, Ma D, Tao Q*, Han W*. CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis. Cancer Res 2009; 69: (12), 5194-5201
10. Guo X, Li T, Wang Y, Shao L, Zhang Y, Ma D, Han W*. CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha. Biochem Biophys Res Commun. 2009; 387(1):139-42.
11. Shao L, Li T, Mo X, Majdic O, Zhang Y, Seyerl M, Schrauf C, Ma D, St？ckl J, Han W*. Expressional and functional studies of CKLF1 during dendritic cell maturation. Cell Immunol. 2010; 263(2):188-95.
12. Plate M, Li T, Wang Y, Mo X, Zhang Y, Ma D, Han W*. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through inducing G2/M phase accumulation. Mol Cells. 2010 Apr; 29(4):355-61.
13. Li H, Guo X, Shao L, Plate M, Mo X, Wang Y, Han W*.CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway. BMB Rep. 2010 Mar; 43(3):182-7.
14. Guo X, Zhang Y, Wang P, Li T, Fu W, Mo X, Shi T, Zhang Z, Chen Y, Ma D, Han W*. VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells. Cell Immunol.2012 Jul; 278(1-2):136-42.
15. Li T, Wang W, Chen Y, Han W*. Preparation and characterization of monoclonal antibodies against VSTM1.Monoclon Antib Immunodiagn Immunother. 2013 Aug; 32(4):283-9.
16. Zhang Y, Wang JY, Han W*. A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells.Int Immunol. 2014 Jan;26(1):47-57.
17. Su Y, Lin Y, Zhang L, Liu B, Yuan W, Mo X, Wang X, Li H, Xing X, Cheng X, Dong B, Hu Y, Du H, Zhu Y, Ding N, Li J, Liu W, Ma Y, Qiu X, Ji J*, Han W*. CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer.Cancer Sci. 2014 Jan; 105(1):26-34.
18. Wang X, Wang W, Lin Z, Wang X, Li T, Yu J, Liu W, Tong Z, Xu Y, Zhang J, Guan L, Dai L, Yang Y, Han W*, Li R*.CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies.J Allergy Clin Immunol. 2014 Mar; 133(3):905-8.
19. Li H, Li J, Su Y, Fan Y, Guo X, Li L, Su X, Rong R, Ying J, Mo X, Liu K, Zhang Z, Yang F, Jiang G, Wang J, Zhang Y, Ma D, Tao Q*, Han W*. A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.Oncogene. 2014 Jun 12; 33(24):3109-18.
20. Pan W, Cheng Y, Zhang H, Liu B, Mo X, Li T, Li L, Cheng X, Zhang L, Ji J, Wang P, Han W*. CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. Sci Rep.2014 Oct 29; 4:6812.