个人简历

教育经历\r
2000.09 - 2004.06 北京大学 高分子化学与物理专业博士\r
1993.09 - 2000.06 青岛化工学院 高分子工程专业本科与硕士\r
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学术简历\r
2019.01 - 至今 北京大学跨学部生物医学工程系研究员，博士生导师\r
2011.10 - 2018.12 清华大学医学院生物医学工程系研究员，博士生导师\r
2007.05 - 2011.08 美国杜克大学生物医学工程系博士后\r
2005.05 - 2007.04 日本京都大学化学研究所博士后

研究领域

"""""生物材料；生物偶联物\r
大分子生物材料；杂化生物材料；蛋白质-高分子/药物/蛋白质/核酸偶联物；药物-高分子偶联物；药物/基因递送；分子影像/诊断；再生医学"

近期论文

Jianwen Guo, Jiawei Sun, Xinyu Liu, Zhuoran Wang, Weiping Gao*. Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology. Biomaterials 2020, 250, 120073.\r
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Chi-Wei Chiang, Xinyu Liu, Jiawei Sun, Jianwen Guo, Lei Tao, Weiping Gao*. Polymerization-induced coassembly of enzyme–polymer conjugates into comicelles with tunable and enhanced cascade activity. Nano Letters 2020, 20, 1383-1387.\r
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Rongzan Lin, Xinghui Yan, Hanjun Hao, Weiping Gao*, Ran Liu*. Introducing temperature-controlled phase transition elastin-like polypeptides to transient electronics: realization of proactive biotriggered electronics with local transience. ACS Appl. Mater. Interfaces 2019, 11, 46490-46496.\r
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Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao*. Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally-programmed two-step release kinetics for tumor therapy. Adv. Sci. 2019, 6，1900586.\r
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Hanjun Hao, Mengmeng Sun, Pengyong Li, Jiawei Sun, Xinyu Liu, Weiping Gao*. In situ growth of a cationic polymer from the N-terminus of glucose oxidase to regulate H2O2 generation for cancer starvation and H2O2 therapy. ACS Appl. Mater. Interfaces 2019, 11, 9756-9762.\r
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Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao* . One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide. Biomater. Sci. 2019, 7, 104-112.\r
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Pengyong Li, Mengmeng Sun, Zhikun Xu, Xinyu Liu, Wenguo Zhao, Weiping Gao*. Site-selective in situ growth-induced self-assembly of protein-polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence imaging. Biomacromolecules 2018, 19, 4472-4479.\r
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Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, Weiping Gao*. Polymerization induced self-assembly of a site-specific interferon a-block copolymer conjugate into micelles with remarkably enhanced pharmacology. J. Am. Chem. Soc. 2018, 140, 10435-10438.\r
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Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang, Weiping Gao*. Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer. Theranostics 2018, 8, 2634-2645.\r
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Xinyu Liu, Jiawei Sun, Weiping Gao*. Site-selective protein modification with polymers for advanced biomedical applications. Biomaterials 2018, 178, 413-434.\r
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Xinyu Liu, Jin Hu, Jianwen Guo, Guilin Wang, Weiping Gao*. Temperature-responsive polymer conjugation of interferon-a enhances antitumor efficacy. Acta Polym. Sin. 2018, 1, 90-98.\r
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Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo*, Weiping Gao*. Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy. J. Control. Release 2017, 264, 66-75.\r
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Wenguo Zhao, Jin Hu, Weiping Gao*. Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy. ACS Appl. Mater. Interfaces 2017, 9，23528-23535.\r
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Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao*. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces 2017, 9, 10453-10460.\r
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Xinyu Liu, Weiping Gao*. In situ growth of self-assembled protein-polymer nanovesicles for enhanced intracellular protein delivery. ACS Appl. Mater. Interfaces 2017, 9, 2023-2028.\r
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Guilin Wang, Jin Hu, Weiping Gao*. Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy. Sci. China Mater. 2017, 60，563-570.\r
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Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao*. In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy. J. Control. Release 2016, 237, 71-77.\r
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Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao*. Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy. Biomaterials 2016, 96, 84-92.\r
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Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao*. Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale 2016, 8, 4452-4457.\r
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Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao*. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha. Adv. Mater. 2015, 27, 7320-7324.