个人简历

教育经历：
医学学士 北京大学医学部，1993年
理学硕士 新加坡国立大学(National U of Singapore), 2001年
医学博士 新加坡国立大学(National U of Singapore), 2005年

工作经历:
骨科医生 北京积水潭医院骨科，1993-1999
博士后研究员 新加坡国立大学干细胞实验室，2005-2006
新加坡千禧年学者 新加坡国立大学干细胞实验室，2006-2007
研究员 北京大学工学院生物医学工程系，2007-

获得荣誉:
1999年卫生部公派赴日临床研修世川奖学金
2006年新加坡千僖年学者 (Singapore Millennium Scholar)
2012年北京大学优秀教师

研究领域

""1. Cartilage Regeneration & Arthritis（软骨再生与关节炎)
Functional Biomaterials
Cell Biology
2.Stem cell（干细胞）
Chondrogenic Differentiation of Mesenchymal Stem Cells into Articular Chondrocytes"""研究领域：
关节软骨再生生物学与再生医学
功能性生物材料
干细胞软骨分化
骨关节炎早期干预治疗"

近期论文

文章发表：
2019
44. Ning, Tong; Zhang, Kun; GE, Zigang. Diverse Effects of Pulsed Electrical Stimulation on Cells – with a Focus on Chondrocytes and Cartilage Regeneration. European Cells & Materials, 38:79-93(2019). pdf
43. Zheng-Zheng Zhang, You-Rong Chen, Shao-Jie Wang, Feng Zhao, Xiao-Gang Wang, Fei Yang, Jin-Jun Shi, Zi-Gang Ge, Wen-Yu Ding, Yu-Chen Yang, Tong-Qiang Zou, Ji-Ying Zhang, Jia-Kuo Yu*, Dong Jiang*. Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus. Science Translational Medicine, 11, eaao0750(2019).pdf
42. Ning, Tong; Guo, Jinsong; Zhang, Kun; Li, Kejia; Zhang, Jue; Yang, Zheng; Ning, Tong; Guo, Jinsong; Zhang, Kun; Li, Kejia; Zhang, Jue; Yang, Zheng; GE, Zigang. Nanosecond Pulsed Electric Fields Enhanced Chondrogenic Potential of Mesenchymal Stem Cells via JNK/CREB-STAT3 Signaling Pathway. Stem Cell Research & Therapy, 10(1):45-56(2019). pdf
41. Fan, Litong; Chen, Jiaqing, Tao, Yanmeng, Yu, Jiakuo, Yang, Zheng; GE, Zigang. Enhancement of the Chondrogenic Differentiation of Mesenchymal Stem Cells and Cartilage Repair by Ghrelin. Journal of Orthopaedic Research,37(6):1387-1397(2019)pdf
2018
40. Chen, J.; Li, Y.; Wang, B.; Yang, J.; Heng, B. C.; Yang, Z.; Ge, Z*.; Lin, J*., TGF-β1 affinity peptides incorporated within a chitosan sponge scaffold can significantly enhance cartilage regeneration. Journal of Materials Chemistry B 2018, 6 (4), 675-687.pdf
2017
39. Yang Zeng,Siyu Feng,Wei Liu,1 Qinyouen Fu,Yaqian Li, Xiaokang Li,1 Chun Chen, Chenyu Huang, Zigang Ge,Yanan Du Preconditioning of mesenchymal stromal cells toward nucleus pulposus-like cells by microcryogels-based 3D cell culture and syringe-based pressure loading system. J Biomed Mater Res, 105B:507-520 (2017).
2016
38. Zhang, Jingjing; Wang, Justin; Zhang, Hui; Lin, Jianhao; Ge, Zigang; Zou, Xuenong. Macroporous interpenetrating network of polyethylene glycol (PEG) and gelatin for cartilage regeneration. Biomedical Materials, 11:035014(2016). pdf
37.Dan Xing, Jiaqing Chen, Jiabei Yang, Boon Chin Heng, Zigang Ge*, Jianhao Lin*. Perspectives on Animal Models Utilized for the Research and Development of Regenerative Therapies for Articular Cartilage. Curr Mol Bio Rep (2016) 2:90–100pdf
36. Jingjing Zhang, Ayeesha Mujeeb, Junxia Feng, Yijiang Li, Yanan Du, Jianhao Lin, Zigang GE*. Physically Entrapped Gelatin in Polyethylene glycol Scaffolds for three-deimensional Chondrocyte Culture. Journal of Bioactive and compatible polymers, 31(5):513-530 (2016).pdf
2015
35. Xiaoyan Tang, Litong Fan, Ming Pei, Li Zeng and Zigang Ge*. Evolving Concepts of Chondrogenic Differentiation: History, State-of-art and Future perspectives. European cells and materials, 30:12-27(2015) (impact Factors:4.89)pdf
34. Jingjing Zhang Ayeesha Mujeeb, Yanan Du, Zigang GE. Probing Cell-Matrix Interactions in RGD-Decorated Macroporous PEG. Biomedical Materials, 10:035016(2015)(impact Factors:3.70).pdf
33. Yijiang Li, Chao Li, Ayeesha Mujeeb, Zhaoxia Jin, Zigang Ge*.Optimization and characterization of chemically modified polymer microspheres and their effect on cell behavior. Materials letters, 154:68-72(2015) (impact Factors:2.49).pdf

2014
32. Yana Dou, Ayeesha Mujeeb, Yufeng Zheng, Zigang Ge*. Optimization of dual effects of Mg-1Ca Alloys on the behavior of Chondrocytes and Osteoblasts in vitro. Progress in Natural Science: Materials International, 24:433-440(2014) pdf

31. Ayeesha Mujeeb, Zigang Ge*. Biomaterials for cartilage regeneration. Journal of the American Academy of Orthopaedic Surgeons.22:674-676(2014) pdf

30. Tianting Zhang, Feng Wen, Yingnan Wu, Graham Seow Hng Goh, Zigang Ge, Lay Poh Tan, James Hoi Po Hui, Zheng Yang. Cross-talk between TGF-beta/SMAD and integrin signaling pathways in regulating hypertrophy of mesenchymal stem cell chondrogenesis under deferral dynamic compression. Biomaterials,38;72-85(2014) pdf

29. Kun Zhang, Jinsong Guo, Zigang Ge*, Jue Zhang. Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/β-catenin Signaling Pathway. Nature Scientific Reports, 4:5836(2014) pdf

28.Jingjng Zhang,Yingnan Wu, Thote, Tanushree, Eng Hin Lee, Zigang Ge*, Zheng Yang.The influence of scaffold micrstructure on chondrogenic differentiation of mesenchymal stem cell. Biomedical Materials, (9):1340001(2014) pdf

27.Yana Dou, Nan Li, Yufeng Zheng, Zigang GE*. Effects of fluctuant magnesium concentration on phenotype of the primary chondrocytes. J Biomed Mater Res Part A :102(12):4456–4463 (2014) pdf

26. Qianqian Han, Chao Li, Haifeng Liu, Gang Wu, Boon Chin Heng, Zigang GE*. Dynamic Changes to Cells during Loading on Porous Scaffolds. Journal of Medical and Biological Engineering, 34(2): 130-136(2014) pdf

2013

25.Kun Zhang, Lili Wang, Qianqian Han, Zheng Yang, Zigang Ge*. Relationship of Initial Cell Seeding Number and Cell Function of Primary Chondrocytes in vitro. Biomeidcal Engineering: Applications, Basis and Communications, 25(5):1340001 (2013). .pdf.

24.Jingjing Zhang, Zheng Yang, Chao Li, Yana Dou, Yijiang Li, Tanushree Thote, Dong-an Wang, and Zigang Ge*. Cells behave distinctly within sponges and hydrogels due to differences of internal structure.Tissue engineering:Part A, 19(19-20):2166-2175(2013).pdf

23.Qianqian Han, Litong Fan, Boon Chin Heng, and Zigang Ge*. Apoptosis and Metabolism of Mesenchymal Stem Cells during Chondrogenic Differentiation In Vitro. International Journal of Tissue Regenetation, 4(3):61-64(2013).fulltext.pdf

22.Kun Zhang, Tanushree Thote, Huji Leng, Robert Guldberg, Zigang Ge*. Effects of pregnancy on progression of osteoarthritis induced by monosodium iodoacetate in rats. Journal of Medical and Biological Engineering 33(5): 449-454 (2013). fulltext.pdf

21.Chao Li, Jingjing Zhang, Shamus Moran, Zigang GE*. Poly（L-Lactide –co- Caprolactone）scaffolds enhanced with poly (β-hydroxybutyrate-co-β- hydroxyvalerate) microspheres as a new system for cartilage tissue engineering. Biomedical Materials, 8(2):025005(2013).fulltext.pdf supplementary data.pdf
Featured article & Editor's pick: http://iopscience.iop.org/1748-605X/page/Interview%20with%20Zigang%20Ge

20.Junfeng Wang, Zhenpeng Guan*, Zigang GE*. Plasma and synovial fluid programmed cell death 5 (PDCD5)
levels are inversely associated with TNF-α and disease activity in patients with rheumatoid arthritis. Biomarkers,18(2):155-159 (2013).fulltext.pdf

2012

19. Lili Wang, Kun Zhang, Chunyang Xiong & Zigang Ge*. Cytotoxicity of core-shell polystyrene magnetic beads and related mechanisms. Molecular & Cellular Toxicity, 8:217-227 (2012). fulltext.pdf

18. Chunhong Zheng, Jingwen Wang, Yuhong Pang, Jianbin Wang, Zigang Ge*. Wenbin Li, and Yanyi Huang*.
High-throughput Immunoassay through In-channel Microfluidic Patterning. Lab on a Chip,12(14):2423-2586 (2012).
Fulltext.pdf
17. Zigang Ge*, Chao Li, Boon Chin Heng, Guoxin Cao, Zheng Yang*. Functional Biomaterials for cartilage regeneration.
Journal of Biomedical Material Research, part A 100A:2526-2536(2012). fulltext.pdf

16. Zheng Yang*, Yingnan Wu, Chao Li, James Hui, Zigang GE*, Eng Hin Lee. Improved mesenchymal stem cells
attachment and in vitro cartilage tissue formation on chitosan-modified poly(Llactide-co-epsilon-caprolactone) scaffold.
Tissue Engineering, Part A, 18 (3,4): 242-251(2012). fulltext.pdf

15. Chao Li, Lili Wang, Zheng Yang*, Gonhyung Kim, Haifeng Chen, Zigang Ge*.
A Viscoelastic Chitosan-modified three-dimensional Porous Poly (L-lactide-co-ε-caprolactone)
Scaffold for Cartilage Tissue Engineering. Journal of Biomaterials Science: Polymer Edition, 23:405-424 (2012).
FullText.pdf

2007-2011
14.Jing Yin，Zheng Yang，Yongping Cao*，Zigang Ge*. Characterization of Human Primary Chondrocytes
of Osteoarthritic Cartilage at Varying Severity. Chinese Medical Journal, 124(24):4245-4253 (2011).fulltext.pdf

13. Hailong Fan, Lili Wang, Keke Zhao, Nan Li, Zujin Shi, Zigang Ge* and Zhaoxia Jin*.
Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan
Composites. Biomacromolecules (2010). （Fulltext.pdf).

12. Qichao Zhao, Jing Yin, Xunda Feng, Zujin Shi, Zigang Ge* and Zhaoxia Jin*. A biocompatible chitosan composite containing phosphotungstic acid modified single-walled carbon nanotubes.Journal of Nanoscience and Nanotechnology, 10:1-4
（2010）.(fulltext.pdf)

11.李超，曹永平，关振鹏，黄德勇，葛子钢*。蛋白聚糖酶和骨关节炎。北京大学学报(医学版)， 41(5):611-613(2009).(fulltext.pdf)

10. Zigang, GE，Xianfeng TIAN, Boon Chin HENG, Victor FAN, Jin Fei YEO, Tong CAO. Histological Evaluation of osteogenesis of 3D-Printed Poly-Lactic-co-glycolic Acid (PLGA) Scaffolds in Rabbit Model. Biomedical Materials, 4(2):1-7(2009). (fulltext.pdf)

9. Zigang Ge, Lishan Wang, Boon Chin Heng, Eunice Phay-Shin Tan, Xian Feng Tian, Kai Lu, Victor Tai-Weng Fan, Jin Fei Yeo, Tong Cao. Proliferation and Differentiation of Human Osteoblasts within 3D printed Poly-Lactic-co-Glycolic Acid (PLGA) Scaffolds, Journal of Biomaterials Applications, 23:533-547 (2009). (fulltext.pdf)

8. Zigang Ge, Zhaoxia Jin, Tong Cao. Manufacture of degradable polymeric scaffolds for bone regeneration. Biomedical Materials, 3(2):1-11 (2008). (fulltext.pdf)

2006 & before

7. Zigang Ge, Yang Hu, Boon Chin Heng, Zheng Yang, Hongwei Ouyang, Eng Hin Lee, Tong Cao*. Osteoarthritis and Therapy. Arthritis Care & Research, 55 (3): 493-500 (2006). (fulltext.pdf)

6. Zigang Ge, Fang Yang, James CH Goh, Seeram Ramakrishna, Eng Hin Lee. Biomaterials and Scaffolds for Ligament Tissue Engineering. Journal of Biomedical Material Research, 77A:639-652 (2006). (fulltext.pdf)

5. Zigang Ge, James CH Goh, Eng Hin Lee. The Effects of Bone Marrow-derived Mesenchymal Stem Cells and Fascia Wrap Application to Anterior Cruciate Ligament Tissue Engineering. Cell Transplantation, 14(10):763-773 (2005).(fulltext.pdf)

4. Zigang Ge, Lishan Wang, Eunice PS Tan, James CH Goh, Eng Hin Lee. Characterization of knitted polymeric scaffolds for potential use in ligament tissue engineering. Journal of Biomaterials Science-polymer edition, 16(9):1179-1192 (2005). (fulltext.pdf)

3. Zigang Ge, James CH Goh, Eng Hin Lee. Selection of cell sources for ligament tissue engineering. Cell Transplantation, 14(8):573-583 (2005). (fulltext.pdf)

2. Zigang Ge, Sophie Baguenard, Lee Yong Lim, Aileen Wee, Eugene Khor*. Hydroxyapatite-chitin materials as potential issueengineered bone substitutes. Biomaterials, 25(6):1049-1058 (2004). (fulltext.pdf)

1.葛子钢，范源，王承武。儿童肱骨髁上骨折神经损伤。中华小儿外科，17(5):291-2 (1996)。(fulltext.pdf)

合作研究：
14. Rui Hao, Jing Yu, Zigang Ge, Lingyun Zhao,Fugeng Sheng,Lili Xu,Gogjie Li and Yanglong Hou. Developing Fe3O4 nanoparticles into an efficient multimodality imaging and therapeutic probe.Nanoscale,5:11954-11963(2013)..pdf

13. Bibek Chandra Sutradhar, Gyeongmi Hong, Zigang Ge* and Gonhyung Kim*.
Co-culture of bovine chondrocytes with demineralized bone matrix in chitosan-alginate
bead enhances chondrogenesis . Journal of Medical and Biological Engineering (online).
12.Son, Jinna; Kim, Yun-Bae; Ge, Zigang; Choi, SeokHwa; Kim, Gonhyung. Bone Healing Effects of Diode Laser (808 nm) on a Rat Tibial Fracture Model.
In vivo (Athens, Greece), 26(4):703-9 (2012).Fulltext.pdf

11. Boon Chin Heng, Mark Richards, Zigang Ge3 and Yimin Shu. Induced adult stem (iAS) cells and induced transit amplifying progenitor (iTAP) cells – a possiblealternative to induced pluripotent stem (iPS) cells? J Tissue Eng Regen Med 2009. (fulltext.pdf)

10. Y.Y. Cai, C.W. Yap, Z. Wang, P.C. Ho, S.Y. Chan, K.Y. Ng, Z.G. Ge and H.S. Lin. Solubilization of vorinostat by cyclodextrins.Journal of Clinical Pharmacy and Therapeutics, 34: 1–6 (2009). (fulltext.pdf)

9. Tian, X-F; Heng, B-C; Ge, Z; Lu, K; Rufaihah, A J; Fan, V T-W; Yeo, J-F; Cao, T. Comparison of osteogenesis of human embryonic stem cells within 2D and 3D culture systems. Scandavia Journal of Clinical & Lab Investigation, 68(1):58-67(2008).

8. Heng, Boon Chin; Ye, Chao Peng; Liu, Hua; Toh, Wei Seong; Rufaihah, Abdul Jalil; Yang, Zheng; Bay, Boon Huat; Ge, Zigang; Ouyang, Hong Wei; Lee, Eng Hin; Cao, Tong. Loss of viability during freeze-thaw of intact and adherent human embryonic
stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis. Journal of Biomedical Science, 13(3): 433-45(2006). (fulltext.pdf)

7. Boon-Chin, Boon, Hua LIU, Zigang GE, Tong CAO. Mechanical dissociation of human embryonic stem cell colonies by manual scraping after collagenase treatment is much more detrimental to cellular viability compared to trypsinization with gentle pipetting. Biotechnology and Applied Biochemistry, 47(1):33-37(2007). (fulltext.pdf)

6. Haifeng Liu, Zigang GE, Yue Wang, Toh-Siew Lok, Vallaya Sutthikhum, James C.H. Goh. Modification of sericin-free silk fibersfor ligament tissue engineering application. Journal of Biomedical Material Research，82B (1):129-138(2007). (fulltext.pdf)

5. Boon-Chin Heng, Hua Liu, Zigang Ge, Tong Cao. Mechanical dissociation of human embryonic stem cell colonies by manual scraping after collagenase treatment is much more detrimental to cellular viability compared to trypsinization with gentle pipetting. Biotechnol.Appl.Biochem. 47(1):33-37(2007). (fulltext.pdf)

4. Zhuo Wang, James Goh, Shamal Das De, Zigang Ge, Hongwei Ouyang, Eng Hin Lee. Efficacy of Bone Marrow Derived Stem Cells in Strengthening Osteoporotic Bone in a Rabbit Model. Tissue Engineering, 12(7): 1753-1761 (2006). (fulltext.pdf)

3. Xinxin Shao, James Goh, Dietmar Hutmacher, , Eng Hin Lee, Zigang Ge. Polymeric poly-c-caprolactone scaffolds and mesenchymal stem cells for regeneration of osteochondrol defects. Tissue Engineering, 12(6):1539-1551(2006). (fulltext.pdf)

2. Boon-Chin Heng, Chao-Peng Ye, Hua Liu, Wei-Seong Toh, Abdul-Jalil Rufaihah, Zheng Yang, Boon-Huat Bay, Zigang Ge, Hong-Wei Ouyang, Eng Hin Lee and Tong Cao. Loss of viability during freeze–thaw of intact and adherent human embryonic stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis. Journal ofBiomedical Science, 23:1-13 (2005). (fulltext.pdf)

1. 闫桂森, 史颖奇, 葛子钢. 肩锁关节损伤8例报道和文献综述. 中华骨科杂志，18(10):633-4 (1998)。(fulltext.pdf)