个人简历

Applied Research in Chemistry and Health research group have several collaborations with industry and universities worldwide. Our main research themes are the detection of TB, cancer therapy, the detection of Botulinum toxin.
Dr Gwenin’s focus is firmly on high value research at the interface of biology and chemistry which has afforded him a strong track record of working with Industry and academia.

近期论文

M. Ali, G. Koza, R. T. Hameed, R. Rowles, C. Davies, J. R. Al Dulayymi, C. D. Gwenin, M. S. Baird, The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters, Tetrahedron, 72, (45), 7143–7158 (2016) DOI:10.1016/ j.tet.2016.08.089
M. O. Mohammed, M. S. Baird, J’aR. Al Dulayymi, A. Jones, C. D. Gwenin, Arabino Mycolates from Synthetic Mycolic Acids, Tetrahedron, 72 (22), 2849–2857 (2016) DOI: 10.1016/j.tet.2016. 03.083
V. Gwenin, P. Paramasivan, J. Halliwell, P. Ball, G. Robinson, C. D. Gwenin, Identification of novel nitroreductases from Bacillus cereus and their interaction with the CB1954 prodrug, Biochemical Pharmacology, 98, 392-402 (2015) DOI: 10.1016/j.bcp.2015.09.01
C. Savage, N. Buckley, J. Halliwell, and C. D. Gwenin, Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy, Toxins, 7, 1544-1555 (2015) DOI:10.3390/toxins7051544
P. Connell, J. Holliman, E. W. Jones, L. Furnell, C. Kershaw, M. L. Davies, C. D. Gwenin, M. B. Pitak, S. J. Coles and G. Cooke, Multiple linker Half-squarylium Dyes for Dye-Sensitized Solar Cells; Are Two Linkers Better than One?, Journal of Materials Chemistry A, 3, 2883-2894 (2014) DOI: 10.1039/C4TA06896C
J. Halliwell, A. C. Savage, N. Buckley and C. D. Gwenin, Electrochemical Impedance Spectroscopy Biosensor for Detection of Active Botulinum Neurotoxin. Sensing and BioSensing Research, 2, 12-15 (2014) DOI: 10.1016/j.sbsr.2014.08.002
P. Holliman, A. Connell, M. L. Davies, S. Weiss, C. D. Gwenin, M. Pitak, P. Horton, S. Coles and G. Cooke, A Study of Dye Anchoring Points in Halfsquarylium Dyes for DyeSensitized Solar Cells, Journal of Materials Chemistry A, 2 (11), 4055 – 4066 (2014) DOI: 10.1039/C3TA15278B
J. Halliwell and C. Gwenin, A Label Free Colorimetric Assay for the Detection of Active Botulinum Neurotoxin Type A by SNAP-25 Conjugated Colloidal Gold. Toxins, 5, 1381-1391 (2013) DOI:10.3390/toxins5081381
L. Barrault, Bedel, E. Charikane, L. Gunnarsen, C. Gwenin, J. Jones, P. Lieberzeit, A. Rowley, T. Soto, S. Thollon, B. Thorstensen, S. Traberg-Borup and N. Wright, Nanosecure: Advanced nanotechnological detection and detoxification of harmful airborne substances for improved public security. Actualite Chimique, 378-379, 27-34. (2013)
C. French and C. Gwenin, Biosensors in bioprocess monitoring and control. In Fermentation Microbiology and Biotechnology, 3rd edition, ed. El-Mansi, M., CRC Press 2011, Boca Raton, Print ISBN: 978-1-4398-5579-9 eBook ISBN: 978-1-4398-5581-2 DOI: 10.1201/b11490-14
V. Gwenin, C. D. Gwenin and M. Kalaji, Colloidal Gold Modified with a Genetically Engineered Nitroreductase: Towards a Novel Enzyme Delivery System for Cancer Prodrug Therapy. Langmuir, 27 14300 (2011) DOI: 10.1021/la202951p
M. Morozova, P. Kluson, J. Krysa, C. Gwenin, O. Solcova, Oxalic acid sensors based on sol-gel nanostructured TiO2 films. Journal of Sol-Gel Science and Technology. 58 (1) 175 (2011) DOI: 10.1007/s10971-010-2374-7
M. Cude, and C. D. Gwenin, Development of gold coated superparamagnetic iron oxide nanoparticles for nitroreductase delivery. ECS Trans. 33, 79 (2011) DOI: 10.1149/1.3583517
C. D. Gwenin, M. Kalaji, C. M. Kay, and P. A. Williams, A kinetic analysis of three modified novel nitroreductases for potential use in explosive detection. Biodegradation 22, 12, 2869-2875 (2010) DOI: 10.1007/s10532-010-9418-0
M. Kalaji, C. D. Gwenin and C. Kay, The development of an amperometric biosensor based on the assembly of genetically engineered enzymes for the detection of explosives. ECS Trans 19, 93-102, (2009) DOI: 10.1149/1.3118541
C. D. Gwenin, M. Kalaji, C. M. Kay, P. A. Williams and D. N. Tito, An in situ amperometric biosensor for the detection of vapours from explosive compounds. Invited article for the special issue of Detection for Security in The Analyst, 133, 621 – 625 (2008) DOI: 10.1039/B713269G
C. D. Gwenin, M. Kalaji, P. A. Williams and R. M. Jones, The orientationally controlled assembly of genetically modified enzymes in an amperometric biosensor. Biosensors and Bioelectronics, Chem and Biosensing Transistors: from materials to systems, 22, 2869-2875, (2007) DOI: 10.1016/j.bios.2006.12.012
C. D. Gwenin, J. P. Jones, M. Kalaji, T. J. Lewis, J. P. Llewellyn and P. A. Williams, Viscoelastic change following adsorption and subsequent molecular reorganisation of a nitroreductase enzyme on a gold surface: A QCM study. Sensors and Actuators B: Chemical, 126(2): 499-507, (2007) DOI: 10.1016/j.snb.2007.03.037