个人简历

University of Wisconsin-Madison, Ph.D., 2006
The University of Texas at Austin, Postdoctoral Fellow, 2006-2012

近期论文

Chang, W. C., Dey, M., Liu, P., Mansoorabadi, S. O., Moon, S. J., Zhao, Z. K., Drennan, C. L., Liu, H. W. (2013) Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction, Nature 496, 114-118.
Kim, H. J., McCarty, R. M., Ogasawara, Y., Liu, Y. N., Mansoorabadi, S. O., Levieux, J., Liu, H. W. (2013) GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme, J. Am. Chem. Soc. 135, 8093-8096.
Chang, W. C., Mansoorabadi, S. O., Liu, H. W. (2013) Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement, J. Am. Chem. Soc. 135, 8153-8156.
Calveras, J., Thibodeaux, C. J., Mansoorabadi, S. O., Liu, H. W. (2012) Sterochemical studies of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation, Chembiochem 13, 42-46.
Tang, K. H., Mansoorabadi, S. O., Reed, G. H., and Frey, P. A. (2009) Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase, Biochemistry 48, 8151-8160.
Munos, J. W., Pu, X., Mansoorabadi, S. O., Kim, H. J., and Liu, H. W. (2009) A secondary kinetic isotope effect study of the 1-deoxy-d-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement, J. Am. Chem. Soc. 131, 2048-2049.
Mansoorabadi, S. O., Magnusson, O. Th., Poyner, R. R., Frey, P. A. and Reed G. H. (2006) Analysis of the cob(II)alamin – 5'-deoxy-3',4'-anhydroadenosyl radical triplet spin system in the active site of diol dehydrase, Biochemistry 45, 14362-14370.
Behshad, E., Ruzicka, F. J., Mansoorabadi, S. O., Chen, D., Reed, G. H. and Frey, P. A. (2006) Enantiomeric free radicals and enzymatic control of stereochemistry in a radical mechanism: The case of lysine 2,3-aminomutases, Biochemistry 45, 12639-12646.
Mansoorabadi, S. O., Seravalli, J., Furdui, C., Krymov, V., Gerfen, G. J., Begley, T. P., Melnick, J., Ragsdale, S. W. and Reed G. H. (2006) EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate:ferredoxin oxidoreductase, Biochemistry 45, 7122-7131.
Sims, P. A., Menefee, A. L., Larsen, T. M., Mansoorabadi, S. O., and Reed, G. H. (2006) Structure and catalytic properties of an engineered heterodimer of enolase composed of one active and one inactive subunit, J. Mol. Biol. 355, 422-431.