个人简历

教育工作经历： 1982－1986年 北京大学生物系生物化学专业，学士 1986－1989年 北京大学生物系生物化学专业，硕士 1989－1995年 美国Rutgers新泽西州立大学微生物学和分子遗传学系，博士 1995－2000年 美国加州大学Santa Barbara分校分子、细胞与发育生物学系，博士后 2000－2003年 美国加州AlleCure/Mannkind免疫生物技术公司研发部，Senior Scientist 2003－2015年 中科院上海生命科学研究院营养科学研究所，研究组长，研究员，博士生导师，“百人计划”择优支持 2008－2015年 中科院营养与代谢重点实验室副主任 2008－2015年 中科院上海生命科学研究院学术委员会委员 2011－2015年 中科院上海营养科学研究所副所长 2015年－至今 武汉大学生命科学学院

研究领域

主要从事糖脂代谢调控的分子生理学机制研究，利用动物模型深入探索营养失衡、细胞应激与代谢紊乱的机制关联，力图深入了解肥胖、脂肪肝与2型糖尿病等衰老相关慢性疾病的分子基础，探寻新的药物干预靶标。

近期论文

1.Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L,Liu Y*.(2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses.J Hepatol.62:590-98. 2.Jiang S, Yan C, Fang QC, Shao ML, Zhang YL,Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z,Liu Y*, Jia WP*. (2014)Fibroblast Growth Factor 21Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis.J Biol Chem.289:29751-65.(Chosen asPaper of the Week) 3.Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X,LiuY*.(2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.Cell Res.24:1137-40. 4.Shao M, Shan B,Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L,LiuY*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Nat Commun.5:3528. 5.Zhang Q,Liu B,Cheng Y,Meng Q,Xia T,Jiang L,Chen S,Liu Y*,Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure.J Biol Chem.289:1779-87. 6.Zhang C, Li S, Yang L, Huang P, Li W, Wang S,ZhaoG, Zhang M, Pang X, Yan Z,LiuY*,ZhaoL*. (2013) Structural modulation of gut microbiota in life-longcalorie-restricted mice.Nat Commun.4:2163. 7.Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L,Liu Y*. (2012)A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors.J Biol Chem.287(45):37973-85. 8.Yu Y,Sun Y,He S,Yan C,Rui L,Li W,Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.Mol Cell Biol.32:3610-23. 9.Zhou B,Yang L,Li S,Huang J,Chen H,Hou L,Wang J,Green CD,Yan Z,Huang X,Kaeberlein M,Zhu L,Xiao H,Liu Y* andHan JD*. (2012)Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions.Proc. Natl. Acad.Sci. U.S.A. Plus109:E1201-9. 10. Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W andLiu Y*. (2011) PKA Phosphorylation Couples Hepatic IRE1ato Glucagon Signaling in Glucose Metabolism.Proc. Natl. Acad.Sci. U.S.A.108:15852-7. 11.Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*,Liu Y*. (2010)Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.FASEB J.24:3720-32. 12. Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W,Liu Y*. (2010)Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice.J. Lipid Res.51:2516-26. 13. You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* andLiu Y*. (2010) Tyr985signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance.Mol. Cell. Biol.30:1650-9.(Highlighted byEditor’s Choice,Science139, 141, 2010 andScience Signaling3, ec95, 2010) 14. Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y,Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals.Cell Metab.11:427-37. 15. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*,Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells.Sci. Signal.3, ra7.(Highlighted inPerspective,Science Signaling3, pe7, 2010) 16. Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W andLiu Y*.(2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.Hepatology49:1166-75. 17. Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*,Liu Y*.(2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.Proc. Natl. Acad.Sci. U.S.A.105: 18619-24.(Highlighted byNature China, 2008) 18. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W,Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells.J. Biol. Chem.281:33386-94.