个人简历

教育背景
1998年9月-2002年7月：山东大学药学院药学专业，获理学学士学位
2002年9月-2005年6月：山东大学药学院药物化学专业，获医学硕士学位
2005年9月-2008年6月：山东大学药学院药物化学专业，获医学博士学位
2010年2月-2014年6月：天津医科大学基础医学博士后科研流动站，博士后

工作经历
2008年10月-2012年10月：天津医科大学药学院，讲师
2012年10月至今：天津医科大学药学院，副教授
2014年12月至今：天津医科大学硕士生导师（招生专业：药物化学）
2016年5月至今：天津医科大学药学院，药物化学教研室主任
2018年12月至今：天津医科大学药学院，药物化学教研室党支部书记
荣誉奖励
1.天津市“131”创新型人才培养工程第二层次人选
2.天津市高校“优秀青年教师资助计划”
3.天津医科大学新世纪优秀人才

研究领域

基于靶点的药物设计、合成和活性研究

近期论文

1. Xiao-Yan Feng, Wen-Qing Jia, Xin Liu, Zhi Jing, Ya-Ya Liu, Wei-Ren Xu, Xian-Chao Cheng*. Identification of novel PPARα/γ dual agonists by pharmacophore screening, docking analysis, ADMET prediction and molecular dynamics simulations. Computational Biology and Chemistry, 2019, 78: 178-189.
2. Ya-Ya Liu, Xiao-Yan Feng, Wen-Qing Jia, Zhi Jing, Wei-Ren Xu, Xian-Chao Cheng*. Identification of novel PI3Kδ inhibitors by docking, ADMET prediction and molecular dynamics simulations. Computational Biology and Chemistry, 2019, 78: 190-204.
3.Mei-Yan Wang, Xian-Chao Cheng (co-first author), Xiu-Bo Chen, Yu Li, Lan-Lan Zang, Yu-Qing Duan, Ming-Zhu Chen, Peng Yu, Hua Sun*, Run-Ling Wang*. Synthesis and biological evaluation of novel N-aryl-omega-(benzoazol-2-yl)-sulfanylalkanamides as dual inhibitors of alpha-glucosidase and protein tyrosine phosphatase 1B. Chemical Biology & Drug Design, 2018, 92 (3): 1647-1656. (SCI IF: 2.404)
4.Wen-Qing Jia, Zhi Jing, Xin Liu, Xiao-Yan Feng, Ya-Ya Liu, Shu-Qing Wang, Wei-Ren Xu, Jian-Wen Liu* and Xian-Chao Cheng*. Virtual identification of novel PPARα/γ dual agonists by scaffold hopping of saroglitazar. Journal of Biomolecular Structure and Dynamics, 2017, Oct, 1-17.
5.Xin Liu, Zhi Jing, Wen-Qing Jia, Shu-Qing Wang, Ying Ma*, Wei-Ren Xu, Jian-Wen Liu* and Xian-Chao Cheng*. Identification of novel PPARα/γ dual agonists by virtual screening, ADMET prediction and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics, 2017, October, 1-15.
6.Xin Liu, Yu-Ze Zhang, Zhi Jing, Wen-Qing Jia, Shu-Qing Wang, Wei-Ren Xu and Xian-Chao Cheng*. Molecular Docking, 3D-QSAR and Structural Optimization of Indole Biphenylcarboxylic Acids as PPARγ Antagonists. Letters in Drug Design & Discovery, 2017, 14, 959-973.
7.Jun Zhang, Xin Liu, Shu-Qing Wang, Gui-You Liu, Wei-Ren Xu, Xian-Chao Cheng* and Run-Ling Wang*. Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ by core hopping of telmisartan. Journal of Biomolecular Structure and Dynamics, 2017, 35 (12): 2665-2680.
8.Jun Zhang, Xin Liu, Xian-Bin Xie, Xian-Chao Cheng*, Run-Ling Wang. Multitargeted bioactive ligands for PPARs discovered in the last decade. Chemical Biology & Drug Design, 2016, 88: 635-663.
9.Jun Zhang,Xin Liu,Shu-Qing Wang,Jing-Wei Fu,Wei-Ren Xu,Xian-Chao Cheng*andRun- Ling Wang. Identification of Novel PPARα/γ Dual Agonists by Virtual Screening of Specs Database. Combinatorial Chemistry & High Throughput Screening,2016, 19 (8): 644-655.
10.Jun Zhang, Xue-Jiao Wang, Zhen-Ke Dong, Shu-Qing Wang, Wei-Ren Xu, Jing-Wei Fu, Xian-Chao Cheng*, Run-Ling Wang. CoMFA/CoMSIA and Molecular Docking Studies of Novel Matrix Metalloproteinase-2 Inhibitors Based on L-tyrosine Scaffold. Letters in Drug Design & Discovery, 2016, 13(5): 376-386.
11.Mei-Yan Wang, Yuan-Yuan Jin, Hui-Yu Wei, Li-Song Zhang, Su-Xia Sun, Xiu-Bo Chen, Wei-Li Dong, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry, 2015, 103, 91-104.
12.Xue-Jiao Wang, Jun Zhang, Shu-Qing Wang, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone. Drug Design, Development and Therapy, 2014, 8, 2255–2262.
13. Lan-Lan Zang, Xue-Jiao Wang, Xiao-Bo Li, Shu-Qing Wang, Wei-Ren Xu, Xian-Bin Xie, Xian-Chao Cheng*, Huan Ma, Run-Ling Wang*. SAHA-based novel HDAC inhibitor design by core hopping method. Journal of Molecular Graphics and Modelling, 2014, 54, 10-18.
14. 王欣, 李游, 桂辛蕊, 程先超*. 二肽基肽酶-4及其抑制剂的研究进展. 中国药学杂志, 2013, 48(21): 1789-1796.
15. Xian-Chao Cheng*, Run-Ling Wang*, Zhen-Ke Dong, Jing Li, Yao-Yuan Li, Rong-Rong Li. Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold. Bioorganic & Medicinal Chemistry, 2012, 20 (19): 5738-5744.
16. Xian-Chao Cheng, Su-Xia Sun, Hao Zhang, Wei-Li Dong, Gui-You Liu, Run-Ling Wang*, Wei-Ren Xu. Synthesis of Novel Imidazolidine-2,4-dione Derivatives as Potential Antidiabetic Agents. Asian Journal of Chemistry, 2011, 23(9): 4114-4116.
17. Xian-Chao Cheng, Xin-Yong Liu*, Wen-Fang Xu, Xiu-Li Guo, Ning Zhang,Yu-Ning Song. Ligustrazine derivatives part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents. Bioorganic & Medicinal Chemistry, 2009, 17 (8): 3018-3024.