个人简历
Education Experience 2004-2008 Ph. D. Biochemistry Martin-Luther University, Halle-Wittenberg,Germany 1995-1998 M.S. Microbial Pharmacy Shenyang Pharmaceutical University, China 1991-1995 Bachelor Microbial Pharmaceutics Shenyang Pharmaceutical University, China Professional Experience 2016- Associate Professor Tianjin University 2009-2016 Postdoctoral Fellow St. Jude Children's Research Hospital, USA 2008-2009 Postdoctoral Fellow Martin-Luther University, Halle-Wittenberg, Germany 2002-2003 UNESCO Course Participant Osaka University & Kyoto University, Japan 1998-2002 Lecture East China University of Science and Technology
研究领域
The research interest of Wu's Lab is to elucidate novel molecular mechanisms that underlie pathological neuronal death and neuronal regeneration and to provide the new therapeutic strategy to treat neurodegenerative disorders. Our primary interests focus on the novel mechanisms common in neuronal degeneration and regeneration contributed by a unique protein post-translational modification, polyglutamylation. Polyglutamylation is a dynamic process in which glutamate residues are added to the γ-carboxyl of a glutamate in the primary amino acid chain of substrate proteins by tubulin tyrosine ligase-like enzymes (TTLLs) and removed by the Cytosolic Carboxypeptidase (CCP) family. The prototype of CCP family, Nna1 (a.k.a CCP1) was discovered in an axon regeneration model and its dysfunction was later found underlying the phenotypes of Purkinje cell degeneration (pcd) mutant mice, in which certain types of neurons undergo progressive degeneration. Interestingly, a growing body of evidence shows that not only deficits of the catabolic process but also the anabolic process of polyglutamylation can cause varieties of neurodegenerative disorders, as well as other anormlies such as male infertility and defective hemostasis. Our lab uses genetically-manipulated mouse model combined with an array of methodologies of biochemistry, cell biology, and structural biology to reveal the genetic pathway and molecular insights that underlie the disorders caused by imbalanced polyglutamylation homeostasis. We are also interested in drug screen using neurodegeneration mouse models.
近期论文
Hui-Yuan Wu, Peng Wei, and James I. Morgan, Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis, Scientific Reports, 2017, 7, 41428 Hui-Yuan Wu, Yongqi Rong, Kristen Correia, Jaeki Min, and James I. Morgan, Comparison of the Enzymatic and Functional Properties of Three Cytosolic Carboxypeptidase Family Members, J. Bio. Chem., 2015, 290:1222-32 Hui-Yuan Wu, Taiyu Wang, Leyi Li, Kristen Correia, and James I. Morgan, A structure-function analysis of Nna1 in Purkinje cell degeneration mice, FASEB J., 2012, 26:4468-80 Hui-Yuan Wu, Muriel Perron and Thomas Hollemann, The role of Xenopus Rx-L in photoreceptor cell determination Dev. Biol., 2009, 327:352-365 Takae Yamauchi, Masaru Goto, Hui-Yuan Wu, Takuma Uo, Tohru Yoshimura, Hisaaki Mihara,Tatsuo Kurihara, Ikuko Miyahara, Ken Hirotsu, and Nobuyoshi Esaki, Serine Racemase with Catalytically Active Lysinoalanyl Residue J. Biochem., 2009, 145:421-424
