个人简历

1983.9-1988.7 上海医科大学药理专业，学士学位
1988.7-1994.11 山东医科大学药学院药理教研室，助教
1994.12-2000.8 山东医科大学药学院药理教研室，讲师，1998年7月获硕士学位
2000.9-今 山东大学药学院新药药理研究所，副教授

研究领域

1. 治疗肾病药物药理学 多种疾病如糖尿病高血压等会累及肾脏，影响肾脏功能，造成蛋白尿、肾小球硬化、终末肾病等。采用糖尿病动物模型和体外细胞培养，研究药物对糖尿病肾病的治疗作用；研究蛋白尿产生的分子机制和预防治疗措施。
2. 抗生素药物药理 细菌耐药是影响抗生素疗效的重要因素。研究大环内酯衍生物对耐药菌株的抗菌活性、抗耐药机制等。

近期论文

1. Yaoqiu Zhu,Jiang Zhou, andBo Jiao.Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents.ACS Med. Chem. Lett.2013,4(3):349–352
2. Guanghua Hu,Bo Jiao.Mechanism of podocyte detachment: Targeting transmembrane molecules between podocytes and glomerular basement membrane.Biomedicine & Aging Pathology,2013,1(3):36–42
3. 高伟，张会鲜，孙建云，焦波*. 珍龙醒脑胶囊对小鼠脑缺氧及脑缺血再灌注损伤的保护作用.中国老年学杂志，2012,32(22)：4958-4910
4. 赵辉，胡晓晶，柳方娥，程艳娜，焦波*. EPA、DHA对脂多糖刺激大鼠系膜细胞表达MMPs、TIMPs及TGF-β1的影响.中国生化药物杂志. 2012，33（3）:221-224
5. Shan J, Zhang B, Zhu Y,Jiao B, Zheng W, Qi X, Gong Y, Yuan F, Lv F, Sun H. Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent.J Med Chem. 2012 Apr 12;55(7):3342-52
6. 张博宇,单佳祺,刘 林,焦波,孙宏斌.普拉格雷类似物的合成及抗血小板聚集活性.中国药科大学学报.2011,42(4):305－309
7.Bo Jiao,Yunshan Wang , Yanna Cheng , Jianjun Gao , Qingzhu Zhang.Valsartan attenuated oxidative stress, decreased MCP-1 and TGF-β1 expression in glomerular mesangial and epithelial cells induced by high-glucose levels.BioScience Trends. 2011; 5(4):173-181.
8.Jiao B,Zhang YH, Cheng YN, Gao JJ, Zhang QZ .A low-dose combination of valsartan and low molecular weight heparin better improved glomerular permeability than did high-dose monotherapy in rats with diabetic nephropathy.Drug Discov Ther.2011; 5(3):119-124
9. Mao JL, Ran XK, Tian JZ,Jiao B, Zhou HL, Chen L, Wang ZG. Design, synthesis and biological evaluation of novel 4-hydroxybenzene acrylic acid derivatives.Bioorg Med Chem Lett.2011 Mar 1;21(5):1549-53.
10. Ma S,Jiao B,Ju Y, Zheng M, Ma R, Liu L, Zhang L, Shen X, Ma C, Meng Y, Wang H, Qi Y, Ma X, Cui W.Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains.Eur J Med Chem. 2011 Feb;46(2):556-66.
11. Zhang L,Jiao B,Yang X, Liu L, Ma S. Synthesis and antibacterial activity of new 4″-O-carbamates of 11,12-cyclic carbonate erythromycin A 6,9-imino ether. J Antibiot (Tokyo),2011 Mar;64(3):243-7.
12. Yunkun Qi,Bo Jiao,Xiaodong Ma, Wenping Cui, and Shutao Ma. Synthesis and Antibacterial Activity of Novel 4''-O-Carbamoyl Erythromycin-A Derivatives.Arch. Pharm. Chem. Life Sci.2010, 8, 458–464
13. 盛林， 邵利娟，郝琳，徐冬玲，王兴蕾，焦波，潘其兴. probucol抑制氧化低密度脂蛋白诱导的大鼠主动脉平滑肌细胞增殖.中国病理生理杂志.2010,26(3):440-445
14. 胡晓晶,耿文静,焦波，柳方娥. EPA、DHA对脂多糖刺激大鼠系膜细胞的保护作用.中国病理生理杂志.2010,26(3):513-517
15. Xue Cui Shen,Bo Jiao, Shu Tao Ma.Synthesis and antibacterial activity of 4”-O-carbamoyl analogs of clarithromycin.Chinese Chemical Letters.21 (2010) 257–260
16. 胡亚洁，焦波*.足细胞裂孔隔膜蛋白质与蛋白尿.生命的化学.2009,29(6):888-892
17. 胡亚洁，焦波*. Effect of high glucose on cytokines secretion in isolated perfused rat kidney and rat mesangial cells.中国药理学通报.2009,25(suppl)341
18. 王允山,焦波*,程艳娜，韩秀珍.缬沙坦联合低分子量肝素对高糖刺激系膜细胞抗氧化系统的影响.中国老年学杂志,2009,29(14):1769-1770
19. 邵利娟，盛林，胡雅洁，程艳娜，焦波*.普罗布考抑制过氧化氢诱导血管平滑肌细胞凋亡的研究.中国药理学通报.2009,25(7):935-8[pdf]
20. Ma S,Jiao B, Liu Z, Wang H, Xian R, Zheng M, Lou H. Synthesis and antibacterial activity of 4'',11-di-O-arylalkylcarbamoyl azithromycin derivatives.Bioorg Med Chem Lett.2009 Mar 15;19(6):1698-701