个人简历

沈小玲 女，四川省犍为县人。广州中医药大学科技创新中心研究员。
教育经历：
1981.09-1985.07，西南师范学院化学系，理学士；1985.08-1988.08，中国科学院昆明植物研究所植物化学研究室，植物学硕士；2002.10-2007.03，香港城市大学生物及化学系分子药理专业，哲学博士。
工作和研究经历：
1988.9-1998.6，西南林学院经济林系，从事植物化学的教学和科研工作；1998.7-2002.5任职广州中医药大学新药开发研究中心，从事中药标准物质和中药质量控制方面的研究工作；2008.4-2009.3在香港浸会大学中医药学院作为博士后学人，从事中药复方质量控制和药效学评价方面的工作；2009年7月入职广州中医药大学热带医学研究所。目前主要研究兴趣：抗肿瘤、抗骨质疏松、降血糖、降血脂中药新药的开发研究。主持过重大新药创制国家科技重大专项《治疗糖尿病1 类新药候选药物树豆酮酸A 的研究》（项目编号2009ZX09103-436），参与了国家科技重大专项“艾滋病和病毒性肝炎等重大疾病防治”《抗HIV中药复方及中医动物模型研究》（项目编号2008ZX10005-005）、“传染病专项”国家科技重大专项《中医药活化潜伏HIV-1，促进病毒库清楚的策略研究》 （项目编号2014ZX10005002）等课题的研究。在Phytochemistry、Biochem Pharmacol、Bioor Med Chem 等刊物上发表SCI论文多篇。担任《中国药理学通报》、《African Journal of Pharmacy and Pharmacology》，《Natural Product Research》等杂志的审稿人。

研究领域

中药学，抗肿瘤、降血糖血脂、抗骨质疏松中药新药研究""

近期论文

1) Xie B, Lu YY, Luo ZH, Qu Z, Zheng CG, Huang XA, Zhou HY, Hu YJ#, Shen XL#. Tenacigenin B ester derivatives from Marsdenia tenacissima actively inhibited CYP3A4 and enhanced in vivo antitumor activity of paclitaxel. J Ethnopharmacol. 2019 May 10;235:309-319. doi: 10.1016/j.jep.2019.02.028. Epub 2019 Feb 14. PMID:30772481
2) Liu S, Luo ZH, Ji GM, Guo W, Cai JZ, Fu LC, Zhou J, Hu YJ#, Shen XL#. Cajanolactone A from Cajanus cajan Promoted Osteoblast Differentiation in Human Bone Marrow Mesenchymal Stem Cells via Stimulating Wnt/LRP5/β-Catenin Signaling. Molecules. 2019 Jan 12;24(2). pii: E271. doi: 10.3390/molecules24020271.
3) Yang R, Wang L, Xie J, Li X, Liu S, Qiu S, Hu Y#, Shen X#. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A. Int J Mol Med. 2018 Nov;42(5):2329-2342. doi: 10.3892/ijmm.2018.3836.
4) Yang RY, Wang L, Xie J, Li X, Liu S, Qiu SX, Hu YJ*, Shen XL*. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A. Int J Mol Med 2018 July 25 (pp.1-14; DOI:10,3892/ijmm.2918.3896).
5) 姚晓辉, 黎欢, 胡阳亮, 胡英杰, 符林春, 沈小玲*.中草药来源的Ⅰ类HDAC抑制剂筛选. 天然产物研究与开发 2018, 30:1099-1104.
6) 黎欢，吴斯东，胡英杰，周娟，沈小玲*. 华萝藦C21甾体成分及其逆转肿瘤细胞多药耐药的作用. 天然产物研究与开发 2017, 29: 756-761, 790.
7) 戴铃林，田汝华，艾香英，张艳平，周 娟，朱瑞静，胡英杰，沈小玲*. 通光散C21甾体成分增强紫杉醇抗肿瘤作用的研究. 中药新药与临床药理 2015,26(3):269-274.
8) Cai JZ, Tang R, Ye GF, Qiu SX, Zhang NL, Hu YJ*, Shen XL*. A Halogen-Containing Stilbene Derivative from the Leaves of Cajanus cajan that Induces Osteogenic Differentiation of Human Mesenchymal Stem Cells. Molecules 2015, 20:10839-10847.
9) Qin JH, Ma JZ, Yang XW, Hu YJ, Zhou J, Fu LC, Tian RH, Liu S, Xu G*, Shen XL*. A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes. Nat Prod Bioprospect 2015, 5:159–166.
10) Zhang JJ, Yang XW, Ma JZ, Ye Y, Shen XL*, Xu G*. Cytotoxic polyprenylated acylphloroglucinol derivatives from Hypericum henryi. Tetrahedron 2015, 71:8315e8319.
11) Wu CY, Liao Y, Yang ZG, Yang XW, Shen XL*, Li RT, Xu G*. Cytotoxic diterpenoids from Salvia yunnanensis. Phytochemistry 2014，106:171-7.
12) Ma JZ, Yang LX, Shen XL*, Qin JH, Deng LL, Ahmed S, Xu HX, Xue DY*, Ye JX & Xu G*. Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells. Nat Prod Bioprospet 2014, 4(4):197-206.
13) Ma JZ, Yang XW, Zhang JJ, Liu X, Deng LL, Shen XL* and Xu G*. Sterols and Terpenoids from Viburnum odoratissimum. Nat Prod Bioprospect. 2014, 4:175-180.
14) Zhu RJ, Shen XL*, Dai LL, Ai XY, Tian RH, Tang R, Hu YJ*. Total aglycones from Marsdenia tenacissima increases antitumor efficacy of paclitaxel in nude mice. Molecules 2014, 19(9):13965-75.
15) 叶贵福, 王璐, 杨瑞仪, 田汝华, 胡英杰, 沈小玲*. 树豆脂溶性部位对糖尿病和肥胖小鼠骨密度及血脂水平的影响.中国药理学通报 2013，29(7):961-5.
16) Shen XL, Chen GY, Zhu GY, Cai JZ, Wang L, Hu YJ and Fong WF. 3ʹ-O,4ʹ-O-aromatic acyl substituted 7,8-pyranocoumarins: a new class of P-glycoproteinmodulators. J Pharm Pharmacol 2012, 64(1):90-100.
17) Xu G, Zhao F, Yang XW, Zhou J, Ynag LX, Shen XL*, Hu YJ and Zhao QS. neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies. Nat Prod Bioprospect 2011, 1:81-86.
18) Li YW, Zhu GY, Shen XL, Chu JH, Yu ZL, Fong WF. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol 2011, 68(5):1315-23 .
19) Li YW, Zhu GY, Shen XL, Chu JH, Yu ZL, Fong WF. Furanodienone inhibits cell proliferation and survival by suppressing ERα signaling in human breast cancer MCF-7 cells. J Cell Biochem 2011, 112(1):217-24.
20) He Q, Shi J, Shen XL, An J, Sun H, Wang L, Hu YJ*, Sun Q, Fu LC, Sheikh MS, Huang Y*. Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells. Cancer Biol Ther 2010; 9(10):819-24.
21) Hu YJ, Shen XL, Lu HL, Zhang YH, Huang XA, Fu LC, Fong WF*. Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells. J Nat Prod 2008, 71(6):1049-51.
22) Fong WF*, Shen XL, Globisch C, Wiese M et al. Methoxylation of 3′,4′-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. Bioorg Med Chem 2008, 16:3694-3703.
23) Shen XL, Chen GY, Zhu GY, Fong WF*. (±)-3'-O, 4'-O-dicynnamoyl-cis-khellactone, a derivative of (±)-praeruptorin A, reverses P-glycoprotein mediated-multidrug resistance in cancer cells. Bioorg Med Chem2006, 14:7138-7145.