个人简历

胡明 ，博士，美国休斯顿大学药剂学教授，广州中医药大学杏林学者讲座教授。
他在世界性的权威杂志上发表了研究性SCI论文143篇，综述性论文30篇，论文引用5955次，H指数为46 （Google Scholar）。主编专著1部并已再版，美国专利或技术授权2项。胡明教授从事生物利用度调控机制研究，获得了美国NIH和NIC等基金的支持，承担了20余项科研项目，共获得超过1000万美元的科研经费，取得许多具有重要意义的研究成果。其研究成果主要体现在4个方面：①首次发现和证明了黄酮类的主要代谢部位为肠道，代谢途径是葡萄糖苷酸和硫酸化； ②首次提出“旋转门”理论，解释了外排泵对二相代谢产物的形成和分泌的“看门人”作用；③首次提出“肠肠循环”和“肠内局部循环”理论，解释了类黄酮在体内表观半衰期长的原因；④首次提出用“生物药剂学指标”和“抗癌活性指标”双重筛选的新思路来寻找更有效的抗癌成分。胡明教授现为Molecular Pharmaceutics, Pharmaceutical Research, Journal of Clinical harmacology, Current Drug Targets, Journal of Alternative and Complementary Medicine, Chinese Journal of Pharmaceutical Sciences, Asia Journal of Pharmaceutical Sciences等SCI期刊的编委。亦为Drug Metabolism and Disposition, Pharmaceutical Research, Molecular Pharmaceutics, Journal of Pharmacology and Experimental Therapeutics, Journal of Biochemical and Molecular Toxicology, Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmaceutical Sciences, Journal of Controlled Release, Journal of Chromatogram B等20多个期刊特邀评审委员。胡明教授是美国联邦政府基金评审员，同时也是法国、新加坡和中国多个基金的特邀评审员。
教育经历
1999-2000，马里兰州贝塞斯达美国国家癌症研究所代谢实验室，访问学者
1988-1990，堪萨斯州劳伦斯堪萨斯大学药物化学系，博士后
1983-1988，密歇根州安阿伯市密歇根大学药学院，博士
1978-1982，上海第一医学院（复旦大学），学士
科研与学术工作经历
2013-至今，广州中医药大学，特聘讲座教授
2012-至今，十堰湖北医学院，特聘讲座教授
2007-2013，广州南方医科大学，特聘讲座教授
2004-至今，休斯顿大学药学院，教授
1997-2004，华盛顿州立大学药学院，副教授
1990-1997，华盛顿州立大学药学院，助理教授
1988-1990，堪萨斯州堪萨斯大学药学院，博士后

研究领域

研究方向为药物吸收与代谢的分子机制，特别是对于黄酮成分的吸收与代谢分子机制的研究造诣非凡。""

近期论文

1 Yu He, Lei Zhou, Song Gao, Taijun Yin, Yifan Tu, Robert Rayford, Xiaoqiang Wang, Ming Hu*. Development and validation of a sensitive LC-MS/MS method for simultaneous determination of eight tyrosine kinase inhibitors and its application in mice pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 148:65-72, 2018.
2 Changhong Yun, Wan-Mohaiza Dashwood, Lawrence N. Kwong, Song Gao, Taijun Yin, Qinglan Ling, Rashim Singh, Roderick H. Dashwood*, Ming Hu∗. Accurate quantification of pge2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 148:42-50, 2018.
3 Yong Ma, Yu He, Taijun Yin, Haoqing Chen, Song Gao, and Ming Hu. Metabolism of Phenolic compounds in LPS-stimulated Raw264.7 cells can impact their Anti-inflammatory efficacy: Indication of hesperetin. Journal of agricultural and food chemistry. 66:6042-6052, 2018.
4 Shufan Ge, Yingjie Wei, Taijun Yin, Beibei Xu, Song Gao, and Ming Hu*. Transport-glucuronidation classification system and pbpk modeling: New approach to predict the impact of transporters on disposition of glucuronides. Molecular pharmaceutics. 14:2884-2898, 2017.
5 Guo Ma, Ying Zhang, Wenyan Chen, Zhifang Tang, Xiaoming Xin, Ping Yang, Xiaoqin Liu, Weimin Cai*, and Ming Hu*. Inhibition of human UGT1A1-Mediated bilirubin glucuronidation by polyphenolic acids impact safety of popular salvianolic acid A/B-Containing drugs and herbal products. Molecular pharmaceutics. 14:2952-2966, 2017.
6 Ming Hu*, Baojian Wu*, Zhongqiu Liu*. Bioavailability of polyphenols and flavonoids in the era of precision medicine. Molecular pharmaceutics. 14:2861-2863, 2017.
7 Guangyi Yang, Shufan Ge, Rashim Singh, Sumit Basu, Katherine Shatzer, Ming Zen, Jiong Liu, Yifan Tu, Chenning Zhang, Jinbao Wei, Jian Shi, Lijun Zhu, Zhongqiu Liu, Yuan Wang, Song Gao and Ming Hu*. Glucuronidation: Driving factors and their impact on glucuronide disposition. Drug metabolism reviews. 49:105-138, 2017.
8 Jianfei Peng, Ming Hu, Song Guo, Zhuofei Du, Jing Zheng, Dongjie Shang, Misti Levy Zamora, Limin Zeng, Min Shao, Yu Sheng Wu, Jun Zheng, Yuan Wang, Crystal R.Glen, Donald R.Collins, Mario J.Molina, and Renyl Zhang*. Markedly enhanced absorption and direct radiative forcing of black carbon under polluted urban environments. Proceedings of the National Academy of Sciences of the United States of America. 113:4266-4271, 2016.
9 Meifang Wang, Guangyi Yang, Yu He, Beibei Xu, Ming Zeng, Taijun Yin, Song Gao, and Ming Hu*. Establishment and use of new mdck ii cells overexpressing both ugt1a1 and mrp2 to characterize flavonoid metabolism via the glucuronidation pathway. Molecular nutrition & food research. 60:1967-1983, 2016.
10 Min Zeng#, Rongjin Sun#, Sumit Basu, Yong Ma, Shufan Ge, Taijun Yin, Song Gao, Jun Zhang*, and Ming Hu. Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides. Molecular nutrition & food research. 60:1006-1019, 2016.