个人简历

郑州大学直聘教授，博士（后），博士生导师，新加坡科技局细胞与分子生物学研究所（IMCB）访问学者、河南省教育厅科技创新人才、河南省教育厅学术技术带头人、郑州大学首批青年拔尖人才、河南省药学会药剂专委会委员、河南省药学会科普专委会委员、Chinese Chemical Letters青年编委及ACS Nano、ACS Applied Materials & Interfaces等多个国际知名SCI期刊审稿人。主要从事抗肿瘤纳米靶向给药系统的相关研究，涉及口服、静脉注射、皮下注射等多种制剂类型及化疗、放疗、免疫治疗等多种治疗方式。先后主持国家自然科学基金面上项目、国家自然科学基金地方联合项目、国家自然科学基金青年项目、中国博士后特别资助项目、中国博士后面上资助项目、河南省科技攻关项目等多个国际级及省部级科研项目。曾获河南省科学技术进步奖一等奖及二等奖、河南省医学科学技术进步奖、河南省优秀科技论文奖、河南省科学技术厅科学技术成果等。已在Advanced Materials（IF：25.803）、Biomaterials（IF：10.273）、ACS Applied Materials & Interfaces（IF：8.456）、Journal of Controlled Release（IF：7.901）等知名TOP期刊发表SCI论文近50篇。在Biomaterials上发表的题为Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes的论文入选美国《基本科学指标数据库》（ESI），成为进入世界前1%的高被引论文。申请专利20余项，授权19项。\r
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2017.01-至今，郑州大学，药学院药物分析系，直聘教授\r
2016.09-2017.08.，新加坡新加坡科技局细胞与分子生物学研究所，访问学者\r
2015.12-2016.12.，郑州大学，药学院药物分析系，副教授\r
2014.03-2018.06.，郑州大学，化学与分子工程学院，博士后\r
2012.10-2015.11，郑州大学，药学院药物分析系，讲师\r
2007.09-2012.06，郑州大学，药物化学，博士\r
2001.09-2006.06，新乡医学院，临床医学，学士\r
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荣誉称号及奖励\r
2019年河南省教育厅科技创新人才\r
2018年河南省科学技术进步奖一等奖\r
2018年河南省教育厅学术技术带头人\r
2018年河南省自然科学优秀学术论文一等奖\r
2018年河南省优秀科技论文奖一等奖\r
2017年河南省科学技术成果奖一等奖\r
2016年河南省科学技术成果\r
2014-2016年河南省优秀科技论文奖一等奖\r
2014年河南省科学技术进步奖二等奖\r
2013年河南省医学科学技术进步奖二等奖

研究领域

"""""从事抗肿瘤纳米靶向给药系统的相关研究，涉及口服、静脉注射、皮下注射等多种制剂类型及化疗、放疗、免疫治疗等多种治疗方式"

近期论文

Qingling Song,CuixiaZheng,JiajiaJia,Hongjuan Zhao,QianhuaFeng,Hongling Zhang, Lei Wang*,Zhenzhong Zhang*, Yun Zhang*, A Probiotic Spore‐Based Oral Autonomous Nanoparticles Generator for Cancer Therapy. Advanced Materials. 2019, 201903793. (影响因子: 25.803；一区)\r
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Lei Wang, Jinjin Shi, Hongling Zhang, Haixia Li, Yan Gao, Zhenzhen Wang, Honghong Wang, Lulu Li, Chaofeng Zhang, Chengqun Chen, Zhenzhong Zhang*, Yun Zhang*, Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes. Biomaterials. 2013, 34, 262-274.（影响因子: 10.273；一区）\r
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HongjuanZhao, Li Li, JunliZhang, CuixiaZheng, KailiDing, HuifangXiao, Lei Wang*, ZhenzhongZhang*. C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer. ACS Applied Materials &Interfaces. 2018;10(37):31124-35.（影响因子: 8.456；一区）\r
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Lei Wang, Panpan Zhang, Jinjin Shi, YongweiHao, DehuiMeng, Yalin Zhao, Yanyan Yin, Dong Li, Junbiao Chang*, Zhenzhong Zhang*, Radiofrequency-triggered tumor-targeting delivery system for theranostics application. ACS Appllied Materials & Interfaces. 2015, 7, 5736-5747. （影响因子: 8.456；一区）\r
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Lei Wang, YujieHu, YongweiHao, Li Li, CuixiaZheng, HongjuanZhao, MengyaNiu, YanyanYin, ZhenzhongZhang*, Yun Zhang*. Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy. Journal of Controlled Release. 2018;286:74-84.（影响因子: 7.901；一区）\r
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YongweiHao, Bingxiang Zhang, CuixiaZheng, RuiJi, XiangyiRen, FangfangGuo, Shili Sun, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Lei Wang*, Yun Zhang*, The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging. Journal of Controlled Release. 2015, 220, 545-555.（影响因子: 7.901；一区）\r
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Qingling Song, JiajiaJia, XiuxiuNiu, CuixiaZheng, Hongjuan Zhao, Lingling Sun, Hongling Zhang, Lei Wang*, Zhenzhong Zhang*, Yun Zhang*. An oral drug delivery system with programmed drug release and imaging properties for orthotopic colon cancer therapy. Nanoscale. 2019,11, 15958-15970.（影响因子：6.97；一区）\r
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Lei Wang, Jinjin Shi, Ruiyuan Liu, Yan Liu, Jing Zhang, Xiaoyuan Yu, Jun Gao, Chaofeng Zhang, Zhenzhong Zhang, Photodynamic effect of functionalized single-walled carbon nanotubes: a potential sensitizer for photodynamic therapy. Nanoscale. 2014, 6, 4642-4651.（影响因子：6.97；一区）\r
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YongweiHao, CuixiaZhen, Lei Wang*, JinjieZhang, XiuxiuNiu, QinglingSong, QianhuaFeng, HongjuanZhao, Li Li, HonglingZhang, ZhenzhongZhang*, Yun Zhang*. Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging. ActaBiomaterialia. 2017;62:293-305.（影响因子: 6.383；一区）\r
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Lei Wang, MengyaNiu, CuixiaZheng, HongjuanZhao, XiuxiuNiu, Li Li, YujieHu, YingjieZhang, Jinjin Shi*, ZhenzhongZhang*. A Core-Shell Nanoplatform for Synergistic Enhanced Sonodynamic Therapy of Hypoxic Tumor via Cascaded Strategy. Advanced Healthcare Materials. 2018:e1800819.（影响因子: 6.27；一区）\r
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Bin Du, Qinghui Wang, Ying Yang, Qian Du, Ying Liu, Wanying Zhu, TianguoXu, GuopengShen, Hanchun Yao*, Lei Wang*. Two-Way Cruise Nanosatellite Promotes Metastasis Inhibition by Immunochemotherapy. Biomacromolecules. 2019;20: 2873-2887.（影响因子: 5.667；一区）\r
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Yanyan Yin, Lingling Cui, Fulin Yan, Zhenzhong Zhang, Wenjie Li, Lei Wang*, Epigallocatechingallate based magnetic gold nanoshellsnanoplatform for cancer theranostic applications. Journal of Materials Chemistry B. 2017, 5, 454-463.（影响因子：5.047；一区）\r
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Lei Wang, Dong Li, YongweiHao, MengyaNiu, Yujie Hu, Hongling Zhang, Junbiao Chang, Zhenzhong Zhang, Yun Zhang, Gold nanorod-based poly(lactic-co-glycolic acid) with manganese dioxide core-shell structured multifunctional nanoplatform for cancer theranostic applications. International Journal of Nanomedicine. 2017, 12, 3059-3075.（一区）\r
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Lei Wang, Jinjin Shi, YongweiHao, Panpan Zhang, Yalin Zhao, DehuiMeng, Dong Li,; Junbiao Chang, Zhenzhong Zhang, Magnetic Multi-Walled Carbon Nanotubes for Tumor Theranostics. Journal of Biomedical Nanotechnology. 2015, 11, 1653-1661.（一区）\r
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Lei Wang, DehuiMeng, YongweiHao, Yujie Hu, MengyaNiu, CuixiaZheng, Yanyan Yin, Dong Li, Panpan Zhang, Junbiao Chang, A gold nanostar based multi-functional tumor-targeting nanoplatform for tumor theranostic applications. Journal of Materials Chemistry B. 2016, 4, 5895-5906.（影响因子：5.047；一区）\r
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YongweiHao#, Lei Wang#, Bingxiang Zhang, Dong Li, DehuiMeng, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Yun Zhang. Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application. International Journal of Nanomedicine. 2016, 11, 1759—1778. （一区）\r
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HongjuanZhao, Li Li, CuixiaZheng, YongweiHao, MengyaNiu, YujieHu, JunbiaoChang, ZhenzhongZhang*, Lei Wang*. An intelligent dual stimuli-responsive photosensitizer delivery system with O2-supplying for efficient photodynamic therapy. Colloids and Surfaces B-Biointerfaces. 2018;167:299-309.（二区）\r
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YongweiHao, Bingxiang Zhang, CuixiaZheng, MengyaNiu, HaochenGuo, Hongling Zhang, Junbiao Chang, Zhenzhong Zhang, Lei Wang*, Yun Zhang*, Multifunctional nanoplatform for enhanced photodynamic cancer therapy and magnetic resonance imaging. Colloids and Surfaces B-Biointerfaces. 2017, 151, 384-393.（二区）\r
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YongweiHao#, Lei Wang#, BingxiangZhang, HongjuanZhao, MengyaNiu, YujieHu, CuixiaZheng, HonglingZhang, JunbiaoChang, ZhenzhongZhang*, Yun Zhang*. Multifunctional nanosheets based on folic acid modified manganese oxide for tumor-targeting theranostic application. Nanotechnology. 2016;27(2):025101.（二区）\r
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Lei Wang, DehuiMeng, YongweiHao, Yalin Zhao, Dong Li, Bingxiang Zhang, Yun Zhang, Zhenzhong Zhang, Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications. Journal of Biomaterials Appllications. 2015, 30, 547-557.（二区）\r
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YongweiHao#, Lei Wang#, YalinZhao, DehuiMeng, Dong Li, HaixiaLi, BingxiangZhang, JinjinShi, HonglingZhang, ZhenzhongZhang*, Yun Zhang*. Targeted Imaging and Chemo-Phototherapy of Brain Cancer by a Multifunctional Drug Delivery System. Macromolecular Bioscience. 2015;15(11):1571-1585.（二区）\r
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Bin Du, TiantianQu, Zheng Chen, Xiaohui Cao, Shuping Han, GuopengShen, Lei Wang*, A novel restricted access material combined to molecularly imprinted polymers for selective solid-phase extraction and high performance liquid chromatography determination of 2-methoxyestradiol in plasma samples. Talanta. 2014, 129, 465-472.（二区）\r
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Lei Wang, Jinjin Shi, XinJia, Ruiyuan Liu, Honghong Wang, Zhenzhen Wang, Lulu Li, Jing Zhang, Chaofeng Zhang, Zhenzhong Zhang, NIR-/pH-Responsive drug delivery of functionalized single-walled carbon nanotubes for potential application in cancer chemo-photothermal therapy. Pharmaceutical Research. 2013, 30, 2757-2771.（二区）\r
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Lei Wang, Mingyue Zhang, Nan Zhang, Jinjin Shi, Hongling Zhang, Min Li, Chao Lu, Zhenzhong Zhang, Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes. International Journal of Nanomedicine. 2011, 6, 2641-2652.（二区）