个人简历

學歷
民國65年，中原大學化學系學士
民國69年，美國德州理工大學化學系碩士
民國74年，美國愛荷華大學化學系博士
經歷
民國74至 75年，美國環境科學研究所客座研究員
民國75至 77年，美國伊利諾大學香檳分校化學系博士後研究員
民國77至 85年，中央研究院原子與分子科學研究所副研究員
民國85年迄今，中央研究院原子與分子科學研究所研究員
民國88至90年，中央研究院原子與分子科學研究所副所長
民國93年迄今，中央研究院基因體研究中心合聘研究員
民國94年迄今，國立陽明大學生醫光電系合聘教授
榮譽及獎項
Chair of the international meeting on “Dynamics and Spectroscopy of Small Molecules and Biomolecules” November 9-12, 2008, Taipei, ROC.
Chair of the international meeting on “Telomeres and Telomerase in Cancer Research”, March 26-29, 2006, Taipei, ROC
Chair of the 7th international meeting on hole burning, single molecule and related spectroscopies. Science and applications. November 18-23, 2001, Taipei, ROC
研究成果
Conformational Transition of a Hairpin Structure to G-Quadruplex within the WNT1 Gene Promoter.
BMVC test, an improved fluorescence assay for detection of malignant pleural effusions.
Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity.
In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands.
Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation.
Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol.

研究领域

凝態中主客分子的交互作用，特別是生物系統上的分子認知與結構動力
設計並合成新型具抗癌性及螢光探針的化合物
利用螢光探針研究染色體端粒之結構變異
抗癌試劑的\" 結構-活性\"的相互關係
研發新的生物分析技術，探討癌細胞中的染色體端粒與端粒酶的作用""

近期论文

Tseng Ting-Yuan, Chu I-Te, Lin Shang-Jyun, Li Jie, Chang Ta-Chau*, 2019, “Binding of Small Molecules to G-quadruplex DNA in Cells Revealed by Fluorescence Lifetime Imaging Microscopy of o-BMVC Foci”, MOLECULES, 24(1):35. (SCI) (IF: 2.861; SCI ranking: 28.8%)
Chu IT, Wu CC, Chang TC*, 2019, “G-quadruplex formation by single-base mutation or deletion of mitochondrial DNA sequences.”, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1863(2):418-425.
Huang MC, Chu IT, Wang ZF, Lin S, Chang TC, Chen CT*, 2018, “A G-Quadruplex Structure in the Promoter Region of CLIC4 Functions as a Regulatory Element for Gene Expression.”, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(9):2678. (SCI) (IF: 3.226; SCI ranking: 40.3%,32.5%)
Tseng TY, Chen WW, Chu IT, Wang CL, Chang CC, Lin MC, Lou PJ, Chang TC*, 2018, “The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers.”, SCIENTIFIC REPORTS, 8:16082. (SCI) (IF: 4.259; SCI ranking: 15.6%)
Li Pei-Tzu, Wang Zi-Fu, Chu I-Te, Kuan Yen-Min, Li Ming-Hao, Huang Mu-Ching, Chiang Pei-Chi, Chang Ta-Chau*, Chen Chin-Tin*, 2017, “Expression of the human telomerase reverse transcriptase gene is modulated by quadruplex formation in its first exon due to DNA methylation”, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(51), 20859-20870. (SCI) (IF: 4.125; SCI ranking: 25.5%)
Wang Zi-Fu, Li Ming-Hao, Chen Wei-Wen, Hsu Shang-Te Danny, Chang Ta-Chau*, 2016, “A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes”, NUCLEIC ACIDS RESEARCH, 44(8), 3958-3968. (SCI) (IF: 10.162; SCI ranking: 4.8%)
Chen Wei-Wen, Yi Yung-Hsiang, Chien Cheng-Hao, Hsiung Kuei-Ching, Ma Tian-Hsiang, Lin Yi-Chun, Lo Szecheng J., Chang Ta-Chau*, 2016, “Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging”, SCIENTIFIC REPORTS, 6(1), 32021-32033. (SCI) (IF: 4.259; SCI ranking: 15.6%)
Yi-Chen Li, Jyh-Horng Wang, Li-Kai Tsai, Yun-An Chen, Ta-Chau Chang, Pei-Jen Lou*, Tai-Horng Young*, 2015, “ 3,6-Bis(1-methyl-4-vinylpyridinium)-carbazole diiodide as a marker for tracking living neural stem/precursor cells”, JOURNAL OF MATERIALS CHEMISTRY B, 3, 2067-2074. (SCI) (IF: 4.543; SCI ranking: 18.2%)
TY Tseng, CC Chang, JJ Lin, TC Chang*, 2015, “A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth”, CURRENT TOPICS IN MEDICINAL CHEMISTRY, 15(19), 1964-1970. (SCI) (IF: 2.864; SCI ranking: 38.3%)
MH Kuo, ZF Wang, TY Tseng, MH Li, ST Hsu, JJ Lin, TC Chang*, 2015, “Conformational Transition of a Hairpin Structure to G-Quadruplex within the WNT1 Gene Promoter”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(1), 210-218. (SCI) (IF: 13.858; SCI ranking: 6%)
WC Huang, TY Tseng, YT Chen, CC Chang, ZF Wang, CL Wang, TN Hsu, PT Li, CT Chen, JJ Lin, PJ Lou, TC Chang*, 2015, “Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents”, NUCLEIC ACIDS RESEARCH, 43(21), 10102-10113. (SCI) (IF: 10.162; SCI ranking: 4.8%)
IT Lin, YL Tsai, CC Kang, WC Huang, CL Wang, MY Lin, PJ Lou, JY Shih, HC Wang, HD Wu, TH Tsai, IS Jan*, TC Chang*, 2014, “BMVC test, an improved fluorescence assay for detection of malignant pleural effusions”, CANCER MEDICINE, 3(1), 162-173. (SCI) (IF: 3.362; SCI ranking: 41.5%)
TL Yang*, L Lin, PJ Lou, TC Chang, TH Young*, 2014, “Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe”, PLOS ONE, 9(1), e86143. (SCI) (IF: 2.806; SCI ranking: 23.4%)
JM Wang, FC Huang, MH Kuo, ZF Wang, TY Tseng, LC Chang, SJ Yen, TC Chang*, JJ Lin*, 2014, “Inhibition of Cancer Cell Migration and Invasion through Suppressing the Wnt1-mediating Signal Pathway by G-quadruplex Structure Stabilizers”, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 289(21), 14612-14623. (SCI) (IF: 4.125; SCI ranking: 25.5%)
YH Yi, CH Chien, WW Chen, TH Ma, KY Liu, YS Chang, TC Chang, SJ Lo, 2014, “Lipid droplet pattern and nondroplet-like structure in two fat mutants of Caenorhabditis elegans revealed by coherent anti-Stokes Raman scattering microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 19(1), 011011. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
ZF Wang, MH Li, ST Hsu, TC Chang*, 2014, “Structural basis of sodium-potassium exchange of a human telomeric DNA quadruplex without topological conversion”, NUCLEIC ACIDS RESEARCH, 42 (7), 4723-4733. (SCI) (IF: 10.162; SCI ranking: 4.8%)
MH Li, ZF Wang, MH Kuo, ST Hsu, TC Chang*, 2014, “Unfolding kinetics of human telomeric g-quadruplexes studied by NMR spectroscopy”, THE JOURNAL OF PHYSICAL CHEMISTRY B, 118(4), 931-936. (SCI) (IF: 3.177; SCI ranking: 33.6%)
Pei-Chi Wei, Zi-Fu Wang, Wen-Ting Lo, Mei-I Su, Jin-Yuh Shew*, Ta-Chau Chang*, Wen-Hwa Lee*, 2013, “A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress”, NUCLEIC ACIDS RESEARCH, 41(3), 1533-1543. (SCI) (IF: 10.162; SCI ranking: 4.8%)
Meng-Chieh Hsieh, Cheng-Hao Chien, Cheng-Chung Chang*, Ta-Chau Chang, 2013, “Aggregation induced photodynamic therapy enhancement based on linear and nonlinear excited FRET of fluorescent organic nanoparticles”, JOURNAL OF MATERIALS CHEMISTRY B, 1, 2350-2357. (SCI) (IF: 4.543; SCI ranking: 18.2%)
SW Liu, JF Chu, CT Tsai, HC Fang, TC Chang, HW Li, 2013, “Assaying the binding strength of G-quadruplex ligands using single-molecule TPM experiments”, ANALYTICAL BIOCHEMISTRY, 436(2), 101-108. (SCI) (IF: 2.334; SCI ranking: 44.7%,63.1%,56.4%)
Wei-Wen Chen, Chen-Hao Chien, Chiung-Lin Wang, Huai-Hsien Wang, Yuh-Lin Wang, Shih-Torng Ding, Tzong-Shyuan Lee, Ta-Chau Chang* , 2013, “Automated quantitative analysis of lipid accumulation and hydrolysis in living macrophages with label-free imaging”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 405(26), 8549-8559. (SCI) (IF: 3.431; SCI ranking: 21.1%,33.3%)
Chi-Chih Kang, Wei-Chun Huang, Chiung-Wen Kouh, Zi-Fu Wang, Chih-Chien Cho, Cheng-Chung Chang, Chiung-Lin Wang, Ta-Chau Chang*, Joachim Seemann, Lily Jun-shen Huang, 2013, “Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity”, INTEGRATIVE BIOLOGY, 5(10), 1217-1228. (SCI) (IF: 3.252; SCI ranking: 49.5%)
Ting-Yuan Tseng, Cheng-Hao Chien, Jen-Fei Chu, Wei-Chun Huang, Mei-Ying Lin, Cheng-Chung Chang, Ta-Chau Chang*, 2013, “Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 18(10), 101309. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
Ting-Yuan Tseng, Zi-Fu Wang, Cheng-Hao Chien, Ta-Chau Chang*, 2013, “In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands”, NUCLEIC ACIDS RESEARCH, 41(22), 10605-10618. (SCI) (IF: 10.162; SCI ranking: 4.8%)
Ya-Shuan Chou, Cheng-Chung Chang, Ta-Chau Chang, Tsung-Lin Yang, Tai-Horng Young, Pei-Jen Lou, 2013, “Photo-induced antitumor effect of 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide”, BIOMED RESEARCH INTERNATIONAL, 2013, 930281. (SCI) (IF: 2.476; SCI ranking: 41.9%,50.8%)
Fon-Zuan Huang, Cheng-Chung Chang, Jing-Min Wang, Ta-Chau Chang*, Jing-Jer Lin*, 2012, “Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity”, BRITISH JOURNAL OF PHARMACOLOGY, 167(2), 393-406. (SCI) (IF: 5.491; SCI ranking: 7.4%)
Cheng-Hao Chien, Wei-Wen Chen, June-Tai Wu, Ta-Chau Chang*, 2012, “Investigation of lipid homeostasis in living Drosophila by coherent anti-Stokes Raman scattering microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 17(12), 126001. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
ZF Wang, TC Chang, 2012, “Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol”, NUCLEIC ACIDS RESEARCH, 40(17), 8711-20. (SCI) (IF: 10.162; SCI ranking: 4.8%)
Cheng-Chung Chang*, Meng-Chieh Hsieh, Jung-Chih Lin, Ta-Chau Chang, 2012, “Selective photodynamic therapy based on aggregation-induced emission enhancement of fluorescent organic nanoparticles”, BIOMATERIALS, 33(3), 897-906. (SCI) (IF: 8.402; SCI ranking: 3%,2.6%)
Ta-Chau Chang*, Jen-Fei Chu, Yu-Lin Tsai, Zi-Fu Wang, 2012, “Structure conversion and structure separation of g-quadruplexes investigated by carbazole derivatives”, CURRENT PHARMACEUTICAL DESIGN, 18(14), 2002-2013. (SCI) (IF: 2.611; SCI ranking: 45.5%)
Jen-Fei Chu, Zi-Fu Wang, Ting-Yuan Tseng, Ta-Chau Chang*, 2011, “A novel method for screening G-quadruplex stabilizers to human telomeres”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 58, 296-300. (SCI) (IF: 0.935; SCI ranking: 77.7%)
Yu-Lin Tsai, Zi-Fu Wang, Wei-Wen Chen, Ta-Chau Chang*, 2011, “Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation”, NUCLEIC ACIDS RESEARCH, 39(17), e114. (SCI) (IF: 10.162; SCI ranking: 4.8%)
Cheng-Hao Chien, Wei-Wen Chen, June-Tai Wu, Ta-Chau Chang*, 2011, “Label-free imaging of Drosophila in vivo by coherent anti-Stokes Raman scattering and two-photon excitation autofluorescence microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 16(1), 016012. (SCI) (IF: 2.53; SCI ranking: 31.5%,32.6%,47.4%)
Chang-Tin Lin, Ting-Yuan Tseng, Zi-Fu Wang, Ta-Chau Chang*, 2011, “Structural conversion of intramolecular and intermolecular G-quadruplexes of bcl2mid: the effect of potassium concentration and ion exchange”, JOURNAL OF PHYSICAL CHEMISTRY B, 115(10), 2360-70. (SCI) (IF: 3.177; SCI ranking: 33.6%)
TC Chang, CC Chang, 2010, “Detection of G-quadruplexes in cells and investigation of G-quadruplex structure of d(T2AG3)4 in K+ solution by a carbazole derivative: BMVC”, METHODS IN MOLECULAR BIOLOGY, 608, 183-206.
Jen-Fei Chu, Ta-Chau Chang, Hung-Wen Li*, 2010, “Single-molecule TPM studies on the conversion of human telomeric DNA”, BIOPHYSICAL JOURNAL, 98(8), 1608-16. (SCI) (IF: 3.656; SCI ranking: 23.3%)