周俭民
近期热点
资料介绍
个人简历
周俭民,博士,研究员,博士生导师教育经历1989-1994年,普度大学园艺系,博士。1984-1987年,中国科学院遗传研究所,硕士。1980-1984年,四川大学生物系,学士。任职经历2012年-现在,中国科学院遗传与发育生物学研究所,研究员。2010-2012年,北京生命科学研究所,资深研究员。2004-2010年,北京生命科学研究所,高级研究员。2002-2005年,堪萨斯州立大学植物病理系,副教授。1997-2002年,堪萨斯州立大学植物病理系,助教授。1994-1997年,普渡大学农学系,博士后。研究领域
同动物一样,植物能通过免疫受体识别病原生物并激活天然免疫反应。实验室的主要兴趣之一是植物识别不同的病原微生物并激活免疫反应的分子机理。此外,病原微生物能向宿主细胞分泌致病蛋白,使它们得以抑制植物的免疫系统、扰乱细胞活动、最终引起病害。实验室的另一个主要兴趣是阐明这些致病蛋白在宿主细胞内的生化功能。"实验室研究内容:同动物一样,植物能通过免疫受体识别病原生物并激活天然免疫反应。实验室的主要兴趣之一是植物识别不同的病原微生物并激活免疫反应的分子机理。此外,病原微生物能向宿主细胞分泌致病蛋白,使它们得以抑制植物的免疫系统、扰乱细胞活动、最终引起病害。实验室的另一个主要兴趣是阐明这些致病蛋白在宿主细胞内的生化功能"近期论文
ReconstitutionandstructureofaplantNLRresistosomeconferringimmunity.WangJ,HuM,WangJ,QiJ,HanZ,WangG,QiY,WangHW,ZhouJM,ChaiJ.Science.2019Apr5;364(6435).pii:eaav5870.doi:10.1126/science.aav5870.Ligand-triggeredallostericADPreleaseprimesaplantNLRcomplex.WangJ,WangJ,HuM,WuS,QiJ,WangG,HanZ,QiY,GaoN,WangHW,ZhouJM,ChaiJ.Science.2019Apr5;364(6435).pii:eaav5868.doi:10.1126/science.aav5868.SmallRNAtraffickingattheforefrontofplant-pathogeninteractions.ZhaoY,LiangX,ZhouJM.F1000Res.2018Oct11;7.pii:F1000FacultyRev-1633.doi:10.12688/f1000research.15761.1.eCollection2018.Review.TheMAP4KinaseSIK1EnsuresRobustExtracellularROSBurstandAntibacterialImmunityinPlants.ZhangM,ChiangYH,Toru?oTY,LeeD,MaM,LiangX,LalNK,LemosM,LuYJ,MaS,LiuJ,DayB,Dinesh-KumarSP,DeheshK,DouD,ZhouJM,CoakerG.CellHostMicrobe.2018Sep12;24(3):379-391.e5.doi:10.1016/j.chom.2018.08.007.Asingletranscriptionfactorpromotesbothyieldandimmunityinrice.WangJ,ZhouL,ShiH,ChernM,YuH,YiH,HeM,YinJ,ZhuX,LiY,LiW,LiuJ,WangJ,ChenX,QingH,WangY,LiuG,WangW,LiP,WuX,ZhuL,ZhouJM,RonaldPC,LiS,LiJ,ChenX.Science.2018Sep7;361(6406):1026-1028.doi:10.1126/science.aat7675.LuciferaseComplementationAssayforProtein-ProteinInteractionsinPlants.ZhouZ,BiG,ZhouJM.CurrProtocPlantBiol.2018Mar;3(1):42-50.doi:10.1002/cppb.20066.[EffectsofNanoscaleZero-valentIron(nZVI)onDenitrifyingPerformanceofanUpflowGranularSludgeBedReactor].RolesofReceptor-LikeCytoplasmicKinaseVIIMembersinPattern-TriggeredImmuneSignaling.RaoS,ZhouZ,MiaoP,BiG,HuM,WuY,FengF,ZhangX,ZhouJM.PlantPhysiol.2018Aug;177(4):1679-1690.doi:10.1104/pp.18.00486.Epub2018Jun15.Receptor-LikeCytoplasmicKinasesDirectlyLinkDiversePatternRecognitionReceptorstotheActivationofMitogen-ActivatedProteinKinaseCascadesinArabidopsis.BiG,ZhouZ,WangW,LiL,RaoS,WuY,ZhangX,MenkeFLH,ChenS,ZhouJM.PlantCell.2018Jul;30(7):1543-1561.doi:10.1105/tpc.17.00981.Epub2018Jun5.Receptor-LikeCytoplasmicKinases:CentralPlayersinPlantReceptorKinase-MediatedSignaling.LiangX,ZhouJM.AnnuRevPlantBiol.2018Apr29;69:267-299.doi:10.1146/annurev-arplant-042817-040540.Danger-AssociatedPeptidesCloseStomatabyOST1-IndependentActivationofAnionChannelsinGuardCells.ZhengX,KangS,JingY,RenZ,LiL,ZhouJM,BerkowitzG,ShiJ,FuA,LanW,ZhaoF,LuanS.PlantCell.2018May;30(5):1132-1146.doi:10.1105/tpc.17.00701.Epub2018Apr30.Ligand-triggeredde-repressionofArabidopsisheterotrimericGproteinscoupledtoimmunereceptorkinases.LiangX,MaM,ZhouZ,WangJ,YangX,RaoS,BiG,LiL,ZhangX,ChaiJ,ChenS,ZhouJM.CellRes.2018May;28(5):529-543.doi:10.1038/s41422-018-0027-5.Epub2018Mar15.ARegulatoryModuleControllingHomeostasisofaPlantImmuneKinase.WangJ,GrubbLE,WangJ,LiangX,LiL,GaoC,MaM,FengF,LiM,LiL,ZhangX,YuF,XieQ,ChenS,ZipfelC,MonaghanJ,ZhouJM.MolCell.2018Feb1;69(3):493-504.e6.doi:10.1016/j.molcel.2017.12.026.Epub2018Jan18.ApoplasticROSsignalinginplantimmunity.QiJ,WangJ,GongZ,ZhouJM.CurrOpinPlantBiol.2017Aug;38:92-100.doi:10.1016/j.pbi.2017.04.022.Epub2017May13.Review.DingzhongTang*,GuoxunWang,andJian-MinZhou*(2017).Receptorkinasesinplantpathogeninteractions:morethanpatternrecognition.PlantCell(invitedreview),doi:10.1105/tpc.16.00891.GuozhiBiandJian-MinZhou*(2017).MAPkinasesignalingpathways:ahubofplant-microbeinteractions.CellHostMicrobe(commentary),21:270-273.LeiLi*,PanyaKim,LipingYu,GaihongCai,SheChen,JamesRAlfano,andJian-MinZhou*(2016).Activation-dependentdestructionofaco-receptorbyaPseudomonassyringaeeffectordampensplantimmunity.CellHostMicrobe,20:504-514.Jian-MinZhou*(2016).Plantpathology:alifeanddeathstruggleinriceblastdisease.CurrBiol.(commentary),26:R843-845.XiangxiuLiang,PingtaoDing,KeihuiLian,JinlongWang,MiaomiaoMa,LinLi,LeiLi,MengLi,XiaojuanZhang,SheChen,YuelinZhang*,Jian-MinZhou*(2016).ArabidopsisheterotrimericGproteinsregulateimmunitybydirectlycouplingtotheFLS2receptor.eLife,DOI:10.7554/eLife.13568DingzhongTang*andJian-MinZhou*(2016).PEPRsspiceupplantimmunity.EMBOJ.(commentary),35:4-5.GuoxunWang,BriceRoux,FengFeng,EndrickGuy,LinLi,NannanLi,XiaojuanZhang,MartineLautier,Marie-FrancoiseJardinaud,MatthieuChabannes,MatthieuArlat,SheChen,ChaozuHe,LaurentD.No?l*,andJian-MinZhou*(2015).TheDecoysubstrateofapathogeneffectorandapseudokinasespecifypathogen-inducedmodified-selfrecognitionandimmunityinplants.CellHostMicrobe,18:285-295.ZhaoyangZhou,YujiaoWu,YongqingYang,MinminDu,XiaojuanZhang,YanGuo,ChuanyouLi,andJian-MinZhou*(2015).AnArabidopsisplasmamembraneprotonATPasemodulatesJAsignalingandisexploitedbythePseudomonassyringaeeffectorproteinAvrBforstomatalinvasion.PlantCell,27:2032-2041.MengLi,XiqingMa,Yi-HsuanChiang,KosteAYadeta,PengfeiDing,LiansaiDong,YanZhao,XiumingLi,YufeiYu,LingZhang,Qian-HuaShen,BinXia,GittaCoaker,DongLiu*,Jian-MinZhou*(2014).Prolineisomerizationoftheimmunereceptor-interactingproteinRIN4byacyclophilininhibitseffector-triggeredimmunity.CellHostMicrobe,16:473-483.LeiLi,MengLi,LipingYu,ZhaoyangZhou,XiangxiuLiang,ZixuLiu,GaihongCai,LiyanGao,XiaojuanZhang,YingchunWang,SheChen,andJian-MinZhou*(2014).TheFLS2-AssociatedkinaseBIK1directlyphosphorylatestheNADPHoxidaseRbohDtocontrolplantimmunity.CellHostMicrobe,15:329-338.YadongSun,LeiLi,AlbertoP.Macho,ZhifuHan*,CyrilZipfel,Jian-MinZhou*,andJijieChai*(2013).Structuralbasisforflg22-inducedactivationoftheArabidopsisFLS2-BAK1immunecomplex.Science,342:624-628.ZixuLiu,YingWu,FangYang,YiyueZhang,SheChen,QiXie,XingjunTian*,andJian-MinZhou*(2013).BIK1interactswithPEPRstomediateethylene-inducedimmunity.PNAS,110:6205-6210.DaolongDouandJian-MinZhou(2012).Phytopathogeneffectorssubvertinghostimmunity:differentfoes,similarbattleground.CellHostMicrbe(invitedreview),12,484-495.FengFengandJian-MinZhou(2012).Plant-bacterialpathogeninteractionsmediatedbytypeIIIeffectors.Curr.Opin.PlantBiol.(invitedreview),doi:10.1016/j.pbi.2012.03.004.FengFeng,FanYang,WeiRong,XiaogangWu,JieZhang,SheChen,ChaozuHe,andJian-MinZhou(2012).AXanthomonasuridine5’-monophosphatetransferaseinhibitsplantimmunekinases.Nature,485,114-118.TingtingXiang,NaZong,JieZhang,JinfengChen,MingshengChen,andJian-MinZhou(2011).BAK1isnotatargetofthePseudomonassyringaeeffectorAvrPto.MPMI,24,100-107.JieZhangandJian-MinZhou(2010).Plantinnateimmunitytriggeredbymicrobialmolecularsignatures.MolecularPlant(invitedreview),5,783-793.YujingWang,JifengLi,ShuguoHou,XingweiWang,YuanLi,DongtaoRen,SheChen,XiaoyanTang,andJian-MinZhou(2010).APseudomonassyringaeADP-RibosyltransferaseinhibitsArabidopsisMitogen-ActivatedProteinKinaseKinases.PlantCell,22,2033-2044.JieZhang,WeiLi,TingtingXiang,ZixuLiu,KristinLaluk,XiaojunDing,YanZou,MinghuiGao,XiaojuanZhang,SheChen,TesfayeMengiste,YuelinZhang,andJian-MinZhou.(2010).Receptor-likecytoplasmickinasesintegratesignalingfrommultipleplantimmunereceptorsandaretargetedbyaPseudomonassyringaeeffector.CellHost&Microbe,7,290-301.YanLi,QingQingZhang,JiangguangZhang,LiangWu,YijunQi,andJian-MinZhou.(2010).IdentificationofmiRNAsinvolvedinPathogen-AssociatedMolecularPattern-triggeredplantinnateimmunity.PlantPhysiol.,152,2222-231.Cui,H.,Wang,Y.,Xue,L.,Chu,J.,Yan,C.,Fu,J.,Chen,M.,Innes,R.W.,andZhou,J.-M.(2010).PseudomonassyringaeeffectorproteinAvrBperturbsArabidopsishormonesignalingbyactivatingMAPKINASE4.CellHost&Microbe,7,164-175.HuaminChen,LiXue,SatyaChintamanani,HugoGermain,HuiqiongLin,HaitaoCui,RunCai,JianruZuo,XiaoyanTang,XinLi,HongweiGuo,andJian-MinZhou(2009).ETHYLENEINSENSITIVE3andETHYLENEINSENSITIVE3-LIKE1repressSALICYLICACIDINDUCTIONDEFICIENT2expressiontonegativelyregulateplantinnateimmunity.PlantCell,25,2527-2540.HaitaoCui,TingtingXiang,andJian-MinZhou(2009).Plantimmunity:Alessonfrompathogenicbacterialeffectorproteins.CellularMicrobiology(invitedreview),11,1453-1461.HuaminChen,YanZou,YuleiShang,HuiqiongLin,YujingWang,RunCai,XiaoyanTang,andJian-MinZhou(2008).Fireflyluciferasecomplementationimagingassayforprotein-proteininteractionsinplants.PlantPhysiol.146:368-376.Jian-MinZhouandJijieChai(2008).PlantpathogenicbacterialtypeIIIeffectorssubduehostresponses.CurrOpinMicrobiol(invitedreview),11,179-185.LinjieChen,HuayiWang,JieZhang,LichuanGu,NiuHuang,Jian-MinZhou,andJijieChai(2008).Structuralbasisforthecatalyticmechanismofphosphothreoninelyase.NatStructMolBiol,15,101-102.TingtingXiang,NaZong,YanZou,YongWu,JieZhang,WeimanXing,YanLi,XiaoyanTang,LihuangZhu,JijieChai,andJian-MinZhou(2008).PseudomonassyringaeeffectorAvrPtoblocksinnateimmunitybytargetingreceptorkinases.CurrBiol,18,74-80.WeimanXing,YanZou,QunLiu,JianingLiu,XiLuo,QingqiuHuang,SheChen,LihuangZhu,RuchangBi,QuanHao,Jia-WeiWu,Jian-MinZhou,andJijieChai(2007).StructuralbasisforactivationofplantimmunitybybacterialeffectorproteinAvrPto.Nature,449,243-247.JieZhang,FengShao,YanLi,HaitaoCui,LinjieChen,HongtaoLi,YanZou,ChengzuLong,LefuLan,JijieChai,SheChen,XiaoyanTang,andJian-MinZhou(2007).APseudomonassyringaeEffectorInactivatesMAPKstoSuppressPAMP-InducedImmunity.CellHost&Microbe,1,175-185.HongtaoLi,HaoXu,YanZhou,JieZhang,ChengzuLong,ShuqinLi,SheChen,Jian-MinZhou,FengShao(2007).ThephosphothreoninelyaseactivityofabacterialtypeIIIeffectorfamily.Science315,1000-1003.YuleiShang,XinyanLi,HaitaoCui,PingHe,RogerThilmony,SatyaChintamanani,JulieZwiesler-Vollick,SureshGopalan,XiaoyanTang,andJian-MinZhou(2006).RAR1,acentralplayerinplantimmunity,istargetedbyPseudomonassyringaeeffectorAvrB.PNAS,103,19200-19205.XiaoyanTangandJian-MinZhou(2006).RegulationofthetypeIIIsecretionsysteminphytopathogenicbacteria.MPMI(review),19,1159-1166.XinyanLi,HuiqiongLin,WeiguoZhang,YanZou,JieZhang,XiaoyanTang,andJian-MinZhou(2005).FlagellininducesinnateimmunityinnonhostinteractionsthatissuppressedbyPseudomonassyringaeeffectors.PNAS,102,12990-12995.FangmingXiao,S.MarkGoodwin,YanmeiXiao,ZhaoyuSun,DouglasBaker,XiaoyanTang,MatthewA.Jenks,andJian-MinZhou(2004)ArabidopsisCYP86A2repressesPseudomonassyringaetypeIIIgenesandisrequiredforcuticledevelopment.EMBOJ.,23,2903-2913.PingHe,SatyaChintamanani,ZhongyingChen,LihuangZhu,BarbaraN.Kunkel,JamesR.Alfano,XiaoyanTang,andJian-MinZhou(2004).ActivationofaCOI1-dependentpathwayinArabidopsisbyPseudomonassyringaetypeIIIeffectorsandcoronatine.ThePlantJournal,37,589-602.LiKang,JianxiongLi,TiehanZhao,FangmingXiao,XiaoyanTang,RogerThilmony,ShengYangHe,andJian-MinZhou(2003).InterplayoftheArabidopsisnonhostresistancegeneNHO1withbacterialvirulence.PNAS,100,3519-3524.PingHe,BerndFriebe,BikramGill,andJian-MinZhou(2003).Allopolyploidyaltersgeneexpressioninthehighlystablehexaploidwheat.PlantMolecularBiology,52,401-414.TharaVenkatappa,JohnFellers,andJian-MinZhou(2003).InplantainducedgenesofPucciniatriticina.MolecularPlantPathology,4,51-56.FangmingXiao,MingLu,TiehanZhao,XiaoyanTang,andJian-MinZhou(2003).PtomutantsdifferentiallyactivatePrf-dependent,AvrPto-independentresistanceandgene-for-generesistance.PlantPhysiology,131,1239-1249.Fang-MingXiao,XiaoyanTang,andJian-MinZhou(2001).Expressionof35S::Ptogloballyactivatesdefensegeneexpressionintomatoplants.PlantPhysiology,126,1637-1645.MingLu,XiaoyanTang,andJian-MinZhou.(2001)ArabidopsisNHO1isrequiredforgeneralresistanceagainstPseudomonasbacteria.PlantCell,13,437-447.LiboShan,VenkatappaThara,GregoryMartin,Jian-MinZhou,andXiaoyanTang(2000).ThePseudomonasAvrPtoproteinisdifferentiallyrecognizedbytomatoandtobaccoandislocalizedtotheplantplasmamembrane.PlantCell,12,2323-2338.2016-现在,BoardofDirectors,InternationalSocietyofMolecularPlant-MicrobeInteractions2016-现在,ReviewEditor,eLife2015-现在,SeniorEditor,CurrentProtocolsinPlantBiology2015-现在,SectionEditor,PLoSPathogens2011-2014,AssociateEditor,PLoSPathogens2007-现在,Editor,MolecularPlant 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