个人简历

周焕斌，男，籍贯湖北武汉，中国农业科学院研究员、博士生导师。
2000年和2003年在华中农业大学园艺学院分别获蔬菜学学士和硕士学位，2007年在中国科学院遗传与发育生物学研究所获遗传学博士学位。2007至2015年分别在美国加州大学河滨分校植物病理与微生物学系、爱荷华州立大学遗传发育与细胞生物学系从事博士后研究工作。2015年4月回国，入职中国农业科学院植物保护研究所，建立基因组编辑实验室，任组长。
研究组现承担国家自然科学基金、中挪国际合作、国家重点研发计划专项、国家转基因重大专项等项目多项。现已申请国家发明专利和PCT国际发明专利共9项，在Cell Host & Microbe, Nucleic Acids Res., Mol. Plant, Genome Biol., Plant Biotech. J., Plant J.等重要学术期刊上发表论文20多篇，其中5篇为ESI高被引论文，总引用率达1800多次。

研究领域

主要从事各种植物、病原微生物基因组编辑技术和工具、以及农作物分子精准育种新方法的研究。借助其进行病原细菌致病因子、水稻基因敲除突变体、功能新种质材料的大规模创制、筛选及鉴定工作。进一步结合遗传学、分子生物学、生物化学、组学、生物信息学等手段深入研究水稻与病原细菌互作的分子机制，发掘重要功能基因资源，加以精准修饰，培育基因组编辑水稻新材料和新品种，服务于我国水稻育种和生产。""

近期论文

回国后主要论文（* 通讯作者）
1.Z Xu, Y Kuang, B Ren, D Yan, F Yan, C Spetz, W Sun, G Wang, X Zhou* & H Zhou*. SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition. Genome Biol. 2020 (Accepted)
2.Y Cao, H Zhou, X Zhou*, F Li*. Control of plant viruses by CRISPR/Cas-mediated adaptive immunity. Front. Microbiol. 2020, https://doi.org/10.3389/fmicb.2020.593700.
3.G Gosavi, F Yan, B Ren, Y Kuang, D Yan, X Zhou & H Zhou*. Applications of CRISPR technology in studying plant-pathogen interactions: overview and perspective. Phytopathol. Res. 2020, https://doi.org/10.1186/s42483-020-00060-z.
4.L Liu, Y Kuang, F Yan, S Li, B Ren, G Gosavi, C Spetz, X Li, X Wang, X Zhou & H Zhou*. Developing a novel artificial rice germplasm for dinitroaniline herbicide resistance by base editing of OsTubA2. Plant Biotech. J. 2020, https://doi.org/10.1111/pbi.13430.
5.M Wang, Z Xu, G Gosavi, B Ren, Y Cao, Y Kuang, C Zhou, C Spetz, F Yan, X Zhou & H Zhou*. Targeted base editing in rice with CRISPR/ScCas9 system. Plant Biotech. J. 2020, 18: 1645-1647.
6.Y Kuang, S Li, B Ren, F Yan, C Spetz, X Li, X Zhou & H Zhou*. Base-editing-mediated artificial evolution of OsALS1 in planta to develop novel herbicide-tolerant rice germplasms. Mol. Plant 2020, 13(4): 565-572.
7.X Yang, H Zhou and X Zhou*. Rock paper scissors: CRISPR/Cas9-mediated interference with geminiviruses in plants. Sci. China. Life Sci. 2019, 62(10): 1389-1391.
8.L Zhang, Q Han, J Xiong, T Zheng, J Han, H Zhou, H Lin, Y Yin & D Zhang*. Sumoylation of BRI1-EMS-SUPPRESSOR 1 (BES1) by the SUMO E3 ligase SIZ1 negatively regulates brassinosteroids signaling in Arabidopsis thaliana. Plant & Cell Physiol. 2019, 60(10): 2282-2292.
9.B Ren, L Liu, S Li, Y Kuang, J Wang, D Zhang, X Zhou, H Lin* & H Zhou*. Cas9-NG greatly expands the targeting scope of the genome-editing toolkit by recognizing NG and other atypical PAMs in rice. Mol. Plant 2019, 12(7): 1015-1026.
10.J. Long, C. Song, F. Yan, J. Zhou, H. Zhou* & B. Yang*. Non-TAL effectors from Xanthomonas oryzae pv. oryzae suppress peptidoglycan-triggered MAPK activation in rice. Front. Plant Sci. 2018, 9: 1857.
11.F. Yan, Y. Kuang, B. Ren, J Wang, D. Zhang, H. Lin, B. Yang, X. Zhou & H. Zhou*. Highly efficient A·T to G·C base editing by Cas9n-guided tRNA adenosine deaminase in rice. Mol. Plant 2018, 11(4): 631-634.
12.B. Ren, F. Yan, Y. Kuang, N. Li, D. Zhang, X. Zhou, H. Lin* & H. Zhou*. Improved base editor for efficiently inducing genetic variations in rice with CRISPR/Cas9-guided hyperactive hAID mutant. Mol. Plant 2018, 11(4): 623-626.
13.旷永洁, 柳浪, 严芳, 任斌, 闫大琦, 张大伟, 林宏辉, 周焕斌*. 水稻与病原物互作中植物激素功能的研究进展. 生物技术通报. 2018, 34(2): 74-86.
14.B. Ren, F. Yan, Y. Kuang, N. Li, D. Zhang, H. Lin* & H. Zhou*. A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice. Sci. China. Life Sci. 2017, 60(5): 516-519.
15.任斌, 严芳, 旷永洁, 李娜, 张大伟, 林宏辉*, 周焕斌*. 基于rBE3和rBE4技术获得的水稻单碱基编辑植株脱靶效率和遗传稳定性. 生物工程学报. 2017, 33(10): 1776-1785.
16.任斌, 严芳, 旷永洁, 李娜, 张大伟, 林宏辉*, 周焕斌*. 水稻靶标基因单碱基定向替换技术的建立. 中国科学:生命科学. 2017, 47(11): 1177-1185.
17.严芳, 周焕斌*. CRISPR/Cas9技术在植物基因功能研究和新种质创制中的应用与展望. 中国科学:生命科学. 2016, 46(5): 498-513.
回国前主要论文（2015之前）
1.H. Zhou, B. Liu, D. P. Weeks, M. H. Spalding & B. Yang. Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice. Nucleic Acids Res. 2014, 42(17): 10903-10914.
2.W. Jian, H. Zhou, H. Bi, M. Fromm, B. Yang & D. P. Weeks. Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res. 2013, 41(20): e188.
3.S. Jiang, J. Yao, K. Ma, H. Zhou, J. Song, S. He & W. Ma. Bacterial effector activates jasmonate signaling by directly targeting JAZ transcriptional repressors. PLoS Pathog. 2013, 9(10): e1003715.
4.H. Zhou, J. Lin, A. Johnson, R. L. Morgan, W. Zhong & W. Ma. Pseudomonas syringae type III effector HopZ1 targets a host enzyme to suppress isoflavone biosynthesis and promote infection in soybean. Cell Host & Microbe 2011, 9(3): 177-186.
5.J. D. Lewis, A. Lee, W. Ma, H. Zhou, D. S. Guttman & D. Desveaux. The YopJ superfamily in plant-associated bacteria. Mol. Plant Pathol. 2011, 12(9):928-937.
6.G. Wang, X. Wei, R. Fan, H. Zhou, X. Wang, C. Yu, L. Dong, Z. Dong, X. Wang, Z. Kang, H. Ling, Q. Shen , D. Wang & X. Zhang. Molecular analysis of common wheat genes encoding three types of cytosolic heat shock protein 90 (Hsp90): functional involvement of cytosolic Hsp90s in the control of wheat seedling growth and disease resistance. New Phytol. 2011, 191(2): 418-431.
7.R. L. Morgan, H. Zhou, E. Lehto, N. Nguyen, A. Bains, X. Wang & W. Ma. Catalytic domain of the diversified Pseudomonas syringae type III effector HopZ1 determines the allelic specificity in plant hosts. Mol. Microbiol. 2010, 76(2): 437-455.
8.H. Zhou, R. L. Morgan, D. S. Guttman & W. Ma. Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems. Mol. Plant Microbe Interact. 2009, 22(2): 176-189.
9.H. Zhou, S. Li, Z. Deng, X. Wang, T. Chen, J. Zhang, S. Chen, H. Ling, A. Zhang, D. Wang & X. Zhang. Molecular analysis of three new receptor-like kinase genes from hexaploid wheat and evidence for their participation in the wheat hypersensitive response to stripe rust fungus infection. Plant J. 2007, 52(3): 420-434.
目前兼任中国植物病理学会常务理事、副秘书长；中国作物学会分子育种分会理事；BMC Plant Biology和Frontiers in Genome Editing杂志Associate editor。