个人简历

教育背景\r
2004-09--2009-06 中国科学院生物物理研究所 博士\r
2000-09--2004-06 武汉大学生命科学学院生物学基地班 学士\r
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工作简历\r
2020-01~现在, 中国科学院生物物理研究所, 研究员\r
2012-01~2019-12,中国科学院生物物理研究所, 副研究员\r
2009-07~2011-12,中国科学院生物物理研究所, 助理研究员\r
2004-09~2009-06,中国科学院生物物理研究所, 博士\r
2000-09~2004-06,武汉大学生命科学学院生物学基地班, 学士\r
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社会兼职\r
2016-01-01-2019-12-31,中国科学院青年创新促进会会员\r
2015-01-01-今,中国生理学会应激生理学专业委员会委员

研究领域

"""""生物物理学实验\r
细胞生物学实验\r
生物活性小分子"

近期论文

Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner, Redox Biology, 2020, 通讯作者\r
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Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities and pathophysiological functions, BioEssays, 2020, 通讯作者\r
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S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, Journal of Biological Chemistry, 2020, 第 8 作者\r
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Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, The EMBO Journal, 2020, 通讯作者\r
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DJ-1 is dispensable for human stem cell homeostasis, Protein & Cell, 2019, 第 6 作者\r
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The b′ domain of protein disulfide isomerase cooperates with the a and a′ domains to functionally interact with platelet αIIbβ3, Journal of Thrombosis and Haemostasis, 2019, 第 3 作者\r
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AtERO1 and AtERO2 exhibit differences in catalyzing oxidative protein folding in the ER, Plant Physiology, 2019, 通讯作者\r
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Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer, EBioMedicine, 2019, 通讯作者\r
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Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis, Redox Biology, 2019, 通讯作者\r
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Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7, Aging Cell, 2018, 通讯作者\r
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Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α, The EMBO Journal, 2018, 通讯作者\r
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Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity, Journal of Biological Chemistry, 2018, 通讯作者\r
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Characterization of the oxidative protein folding activity of a unique plant oxidoreductase, Arabidopsis protein disulfide isomerase-11, Biochemical and Biophysical Research Communications, 2018, 通讯作者\r
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Novel roles of the non-catalytic elements of yeast protein-disulfide isomerase in its interplay with endoplasmic reticulum oxidoreductin 1, Journal of Biological Chemistry, 2016, 通讯作者\r
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Protein disulfide–isomerase, a folding catalyst and a redox-regulated chaperone, Free Radical Biology and Medicine, 2015, 第 1 作者\r
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Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α), Journal of Biological Chemistry, 2014, 通讯作者\r
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Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding, Antioxidants & Redox Signaling, 2014, 第 1 作者\r
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The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation, Biochemical Journal, 2011, 第 1 作者\r
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Reconstitution of Human Ero1-Lα/Protein-Disulfide Isomerase Oxidative Folding Pathway in Vitro POSITION-DEPENDENT DIFFERENCES IN ROLE BETWEEN THE a AND a′ DOMAINS OF PROTEIN-DISULFIDE ISOMERASE, Journal of Biological Chemistry, 2009, 第 1 作者