个人简历

松田善卫，1985年获得日本高知医科大学药学M.D.学位，1989年获日本高知医科大学医药科学博士学位。1993年获得美国哈佛大学公共卫生学院（Harvard T.H. Chan School of Public Health）病毒学科学博士学位。1994-1996年任哈佛大学公共卫生学院副研究员。1996-2006年先后在日本国立感染症研究所艾滋病研究中心任主任研究官，室长。从2006年起先后担任东京大学亚洲感染症研究中心特任准教授，特任教授，中科院生物物理研究所蛋白质与多肽药物所重点实验室客座研究员

研究领域

HIV-1病毒蛋白结构与功能之间的关系

近期论文

1. Yamamoto M, Matsuyama S, Li X, Takeda M, Kawaguchi Y, Inoue JI, Matsuda Z. Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome (MERS) corona virus S-mediated membrane fusion using the split protein-based cell-cell fusion assay. Antimicrob Agents Chemother. 60 (11): 6532-6539, 2016
2. Saw WT, Matsuda Z, Eisenberg RJ, Cohen GH, Atanasiu D. Using a split luciferase assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins. Methods. 90:68-75, 2015
3. Nakane S, Matsuda Z. Dual Split Protein (DSP) Assay to Monitor Cell-Cell Membrane Fusion. Methods Mol Biol. 1313:229-36, 2015.
4. Nakane S, Iwamoto A, Matsuda Z. The V4 and V5 Loops of HIV-1 Envelope Glycoprotein are Tolerant to Insertion of Green Fluorescent Protein and are Useful Targets for Labeling. J Biol Chem. 290:15279-15291, 2015
5. Matsuda Z. Recent advance in the structural analysis of HIV-1 envelope protein. Sci China Life Sci. 58:420-424, 2015
6. Wang H, Li X, Nakane S, Liu S, Ishikawa H, Iwamoto A, Matsuda Z. Co-expression of foreign proteins tethered to HIV-1 envelope glycoprotein on the cell surface by introducing an intervening second membrane-spanning domain. PLoS One. 7; 9 (5):e96790, 2014
7. Teeranaipong P, Hosoya N, Kawana-Tachikawa A, Fujii T, Koibuchi T, Nakamura H, Koga M, Kondo N, Gao GF, Hoshino H, Matsuda Z, Iwamoto A., Development of a rapid cell-fusion-based phenotypic HIV-1 tropism assay. J Int AIDS Soc. 16(1):18723, 2013
8. Atanasiu D, Saw WT, Gallagher JR, Hannah BP, Matsuda Z, Whitbeck JC, Cohen GH, Eisenberg RJ., Dual split protein-based fusion assay reveals that mutations to herpes simplex virus (HSV) glycoprotein gB alter the kinetics of cell-cell fusion induced by HSV entry glycoproteins. J Virol. 87(21): 11332-45. 2013
9. Ishikawa H, Meng F, Kondo N, Iwamoto A, Matsuda Z, Generation of a dual-functional split-reporter protein for monitoring membrane fusion using self-associating split GFP. Protein Eng Des Sel. 2012
10. Toda T, Kuwahara K, Kondo N, Matsuda Z, Maeda Y, Maeda K, Sakaguchi N., Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4. Immunobiology. 217:864-72, 2012.
11. Long Y, Meng F, Kondo N, Iwamoto A, Matsuda Z, Conserved arginine residue in the membrane-spanning domain of HIV-1 gp41 is required for efficient membrane fusion. Protein Cell. 2:369-76. 2011
12. Liu S, Kondo N, Long Y, Xiao D, Iwamoto A, Matsuda Z, Membrane topology analysis of HIV-1 envelope glycoprotein gp41., Retrovirology. 7,100, 2010
13. Miyauchi K, Curran AR, Long Y, Kondo N, Iwamoto A, Engelman DM, Matsuda Z, The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein. Retrovirology. 7,95, 2010
14. Kondo N, Miyauchi K, Meng F, Iwamoto A, Matsuda Z, Conformational changes of the HIV-1 envelope protein during membrane fusion are inhibited by the replacement of its membrane-spanning domain. J Biol Chem. 285, 14681-1468, 2010