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黄亿华
2023-05-18 16:02
  • 黄亿华
  • 黄亿华 - 研究员 博导--黄亿华-个人资料

近期热点

资料介绍

个人简历


1990-1995 北京大学生命科学学院,获理学学士学位
1995-1998 北京大学生命科学学院,获理学硕士学位
1998-2004 美国康奈尔大学医学院生物化学系,获博士学位
2004-2010 美国德州大学西南医学中心/霍华德休斯医学研究所博士后、研究助理和讲师
2011-今 中国科学院生物物理研究所,研究员

研究领域


膜蛋白的生成与蛋白质的跨膜转运机理;生物膜的生成

近期论文


Yanlong Xin, Yan Zhao, Jiangge Zheng, Haizhen Zhou, XuejunCai Zhang, Changlin Tian(*), and Yihua Huang*.(2017)Structure of YidC from Thermotogamaritima and its implications forYidC-mediated membrane protein insertion . FASEB J. Accepted.
Qingshan Luo , Xu Yang , Shan Yu , Huigang Shi , Kun Wang , Le Xiao , Guangyu Zhu , Chuanqi Sun ,Tingting Li , Dianfan Li , Xinzheng Zhang , Min Zhou &Yihua Huang*.(2017)Structural basis for lipopolysaccharide extractioby ABC transporter LptB2FG. Nat StructMol Biol. May;24(5):469-74
Han L, Zheng J, Wang Y, Yang X, Liu Y, Sun C, Cao B, Zhou H, Ni D, Lou J, Zhao Y, Huang Y*. (2016)Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins. Nat Struct Mol Biol. Mar; 23(3):192-6
Yan Wang, Archana AndolePannuri, Dongchun Ni, Haizhen Zhou, Xiou Cao, Xiaomei Lu, Tony Romeo & Yihua Huang. (2016) Structural basis for translocation of a biofilm-supporting exopolysaccharide across the bacterial outer membrane. J. Biol. Chem 291(19):10046-57
Ni D, Huang Y*. (2015)The Expression, Purification, and Structure Determination of BamA from E. coli. Methods Mol Biol. 1329:169-78.
Shuai Qiao., Qingshan Luo., Yan Zhao., Xuejun Cai Zhang. & Yihua Huang. (2014) Structural basis for lipopolysaccharide insertion in the bacterial outer membrane. Nature, 511(7507):108–111.
Baohua Cao.,Yan Zhao.,Yongjun Kou.,Dongchun Ni.,Xuejun Cai Zhang. & Yihua Huang. (2014) Structure of the nonameric bacterial amyloidsecretionchannel. PNAS, 111(50):E5439-44.
Dongchun Ni.,Yan Wang.,Xu Yang., Haizhen Zhou.,Xiaomin Hou.,Baohua Cao.,Zhixin Lu., Xinsheng Zhao., Kun Yang. & Yihua Huang.(2014) Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli. The FASEB Journal, 28(6):2677-85.
Huang Y., Smith B.,Chen L.,Baxter R.& Deisenhofer J.(2009) Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC. PNAS, 106(18):7403-7.
Huang Y., Baxter R., Smith B.S., Partch C.L., Colbert C.L.& Deisenhofer J.(2006) Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implication for photolyase activity. PNAS, 103(47):17701-6.
Huang Y., Lu M.& Wu H.(2004) Antagonizing XIAP-mediated caspase-3 inhibition: Achilles' heel of cancers? Cancer Cell. 5(1):1-2
Huang Y., Rich R., Myszkat D.& Wu H.(2003) Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. J. Biol. Chem. 278(49):49517-22
Huang Y., Park Y.C., Rich R.L., Segal D., Myszka D. G.& Wu H.(2001) Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell, 104:781-790. 

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